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Use of protocatechuic acid and composition containing protocatechuic acid

A technology of protocatechuic acid and composition, applied in the field of biochemistry, to achieve the effects of improving immunity, improving obesity, and eliminating liver metabolic burden and damage

Inactive Publication Date: 2020-04-14
HUNAN AGRICULTURAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the process of studying the phenolic metabolites of cyanidin-3-glucoside, the present invention unexpectedly found that protocatechuic acid can effectively improve obesity, metabolic diseases, liver damage and intestinal microbial ecological environment caused by high-energy diet disordered problem

Method used

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  • Use of protocatechuic acid and composition containing protocatechuic acid
  • Use of protocatechuic acid and composition containing protocatechuic acid
  • Use of protocatechuic acid and composition containing protocatechuic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] (1) Break the high-fat diet intermittently with a pulverizer (stop once in 1-2s to avoid overheating);

[0053] (2) Add protocatechuic acid standard substance to the powdered high-fat diet at an additive amount of 4g / kg (0.4%);

[0054] (3) Adopt the principle of step-by-step premixing (at least three levels), mix the standard product and high-fat feed, and wait until the standard product is completely dissolved in the high-fat feed (the fine particles of the standard product cannot be seen by flattening the mixed feed by hand);

[0055] (4) The mixed feed is made into round mixed feed of suitable size, marked in bags, and stored in a -20°C refrigerator.

Embodiment 2

[0057] (1) Break the high-fat diet intermittently with a pulverizer (stop once in 1-2s to avoid overheating);

[0058] (2) Add protocatechuic acid standard product to the powdered high-fat diet according to the additive amount of 0.25g / kg (0.025%);

[0059] (3) Adopt the principle of step-by-step premixing (at least three levels), mix the standard product and high-fat feed, and wait until the standard product is completely dissolved in the high-fat feed (the fine particles of the standard product cannot be seen by flattening the mixed feed by hand);

[0060] (4) The mixed feed is made into round mixed feed of suitable size, marked in bags, and stored in a -20°C refrigerator. The photo of the finished product of this embodiment is shown in figure 1 As shown in B, figure 1 A is a high-fat diet without protocatechuic acid added. It can be seen that the high-energy diet containing protocatechuic acid prepared in this example has a good degree of shaping.

Embodiment 3

[0062] (1) Break the high-fat diet intermittently with a pulverizer (stop once in 1-2s to avoid overheating);

[0063] (2) Add protocatechuic acid standard product to powdered high-fat diet at an additive amount of 1g / kg (0.1%);

[0064] (3) Adopt the principle of step-by-step premixing (at least three levels), mix the standard product and high-fat feed, and wait until the standard product is completely dissolved in the high-fat feed (the fine particles of the standard product cannot be seen by flattening the mixed feed by hand);

[0065] (4) The mixed feed is made into round mixed feed of suitable size, marked in bags, and stored in a -20°C refrigerator. The photo of the finished product of this embodiment is shown in figure 1 As shown in C, figure 1 A is a high-fat diet without protocatechuic acid added. It can be seen that the high-energy diet containing protocatechuic acid prepared in this example has a good degree of shaping.

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Abstract

The invention relates to a use of protocatechuic acid and a composition containing the protocatechuic acid, in particular to a use of protocatechuic acid in preparation of products for preventing and / or improving symptoms caused by high-energy diet intake, and the symptoms comprise obesity, metabolic diseases caused by excessive fat, impaired liver functions and intestinal flora disorder. Protocatechuic acid has a wide application prospect in the fields of medicines, foods and feeds. When protocatechuic acid is applied to high-fat feed, intestinal tract micro-ecological environment disturbanceand liver metabolism burden and damage caused by high-fat daily ration can be effectively eliminated, so that the utilization rate of nutrient substances by animals is increased, the immunity of theanimals is improved, and the production performance of the animals is improved.

Description

technical field [0001] The invention relates to the field of biochemistry, in particular to the use of protocatechuic acid and a composition containing the protocatechuic acid. Background technique [0002] Anthocyanin is a secondary metabolite with a polyphenolic structure widely present in plants. They act as important antioxidants and pigments that give plants their characteristic colour. Although anthocyanins vary in different plants, six anthocyanins, including geranium pigment, cyanidin, delphinium pigment, paeoniflorin pigment, morning glory pigment, and mallow pigment, are considered to be the main natural anthocyanins. Berries such as red raspberry (scientific name Rubus idaeus L.), blue indigo fruit (scientific name Lonicera caerulea L.), and mulberry have been traditionally used as folk medicines, and their extracts have been used in recent years to treat cardiovascular diseases, obesity, neurodegeneration, Diseases such as liver disease and cancer. Cyandrin-3-...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61P1/16A61P1/00A61P3/04A61P3/10A61P3/00A61P9/00A61P13/12A61P35/00A23L33/105A23K20/111
CPCA23K20/111A23L33/105A23V2002/00A61K31/192A61P1/00A61P1/16A61P3/00A61P3/04A61P3/10A61P9/00A61P13/12A61P35/00A23V2250/2106A23V2200/332A23V2200/328A23V2200/326A23V2200/308A23V2200/3262A23V2200/32A23V2200/30A23V2250/2132
Inventor 伍树松谭继君刘明胡睿智李岩利严佳豪贺建华张宏福
Owner HUNAN AGRICULTURAL UNIV
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