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Chitosan-cellulose composite hemostatic sponge as well as preparation method and application thereof

A technology of hemostatic sponge and cellulose, which can be used in applications, pharmaceutical formulations, surgical adhesives, etc. It can solve the problems of hemostatic sponge coagulation effect and unsatisfactory liquid absorption ability, and achieve the advantages of red blood cell aggregation, mild reaction conditions, and air permeability Good results

Active Publication Date: 2020-04-10
INST OF MEDICAL SUPPORT TECH OF ACAD OF SYST ENG OF ACAD OF MILITARY SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The current hemostatic sponge generally has the problem of unsatisfactory blood coagulation effect and liquid absorption capacity

Method used

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  • Chitosan-cellulose composite hemostatic sponge as well as preparation method and application thereof
  • Chitosan-cellulose composite hemostatic sponge as well as preparation method and application thereof
  • Chitosan-cellulose composite hemostatic sponge as well as preparation method and application thereof

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preparation example Construction

[0030] A preparation method of chitosan-cellulose composite hemostatic sponge, comprising the steps of:

[0031] (1) Using NaIO 4 Oxidizing cellulose nanocrystals to prepare dialdehyde-based cellulose;

[0032] (2) described chitosan and dialdehyde base cellulose are m according to mass ratio 壳聚糖 :m 二醛基纤维素 =0.2-10 mixed to prepare the composite hemostatic sponge.

[0033] In some embodiments of the present invention, the step (1) specifically includes the following steps:

[0034] Sodium metaperiodate NaIO 4 Added into deionized water, the concentration is 2.0wt%-5.0wt%, after dissolving completely, add cellulose nanocrystal, wherein, m NaIo4 :m 纤维素纳米品 =0.8-1.6, stir for 24h-72h under dark conditions, add NaIO to remove excess 4 , get NaIO 4 The cellulose nanocrystal dispersion liquid of oxidation; The NaIO 4 The oxidized cellulose nanocrystal dispersion is centrifuged, and the gel is obtained at the bottom, washed with deionized water, 50% ethanol solution by volume,...

Embodiment 1

[0042] A preparation method of chitosan-cellulose composite hemostatic sponge, comprising the steps of:

[0043] (1) Dialdehyde-based cellulose: get a certain amount of sodium metaperiodate NaIO 4 Add it into 100mL deionized water, add corresponding proportion of cellulose nanocrystal CNC after dissolving completely, m NaIo4 :m CNC =1.6, stir for 24h under dark conditions, add 10mL ethylene glycol, react for 0.5-1h, remove excess NaIO 4 , get NaIO 4 Oxidized cellulose nanocrystal dispersion;

[0044] (2) Centrifuge the solution obtained in the step (1) to obtain a gel at the bottom, wash it with deionized water, 50% ethanol solution, absolute ethanol, and deionized water successively, freeze it at -20°C, and place it in a lyophilizer Freeze-drying in medium to obtain dialdehyde-based cellulose (DAC);

[0045] (3) Take a certain amount of DAC, add it to water, heat and dissolve it in an oil bath at 100°C, configure it as a DAC aqueous solution, and cool it for later use; ...

Embodiment 2

[0048] A preparation method of chitosan-cellulose composite hemostatic sponge, comprising the steps of:

[0049] (1) Dialdehyde-based cellulose: get a certain amount of sodium metaperiodate NaIO 4 Add it into 100mL deionized water, add corresponding proportion of cellulose nanocrystal CNC after dissolving completely, m NaIO4 :m CNC =1, stir for 48h under dark conditions, add 10mL ethylene glycol, react for 0.5-1h, remove excess NaIO 4 , get NaIO 4 Oxidized cellulose nanocrystal dispersion;

[0050] (2) Centrifuge the solution obtained in the step (1) to obtain a gel at the bottom, wash it with deionized water, 50% ethanol solution, absolute ethanol, and deionized water successively, freeze it at -20°C, and place it in a lyophilizer Freeze-drying in medium to obtain dialdehyde-based cellulose (DAC);

[0051] (3) Take a certain amount of DAC, add it to water, heat and dissolve it in an oil bath at 100°C, configure it as a DAC aqueous solution, and cool it for later use;

...

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Abstract

The invention belongs to the technical field of biomedical materials, and discloses chitosan-cellulose composite hemostatic sponge as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) preparing dialdehyde cellulose by adopting NaIO4 oxidized cellulose nanocrystalline; and (2) mixing commercially available deacetylated chitosan of whichthe molecular weight is 180000-300000Da and the deacetylation degree is 80-95% with dialdehyde cellulose according to a mass ratio of m chitosan to m dialdehyde cellulose of 0.2-10 to prepare the composite hemostatic sponge. The composite hemostatic sponge has the advantages of being good in blood coagulation effect and high in absorption capacity.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a chitosan-cellulose composite hemostatic sponge and its preparation method and application. Background technique [0002] The description of the background technology of the present invention belongs to the relevant technology related to the present invention, and is only used to illustrate and facilitate the understanding of the content of the present invention. prior art on the filing date. [0003] Traumatic hemorrhage is a leading cause of military and civilian casualties. Aortic hemorrhage has been reported to cause 50% of battlefield casualties and 31% of fatalities in civilian clinical settings. Timely hemostasis is crucial to reduce blood loss, treat bleeding trauma, and improve survival rate. [0004] Chitosan (CS) is a linear polysaccharide with the structural formula β-(1→4)-2-amino-2-deoxy-D-glucose, which can be synthesized from chitin, one of the mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00
CPCA61L24/0068A61L24/0036A61L2400/04A61L2300/418C08L5/08
Inventor 林松魏晓慧田丰
Owner INST OF MEDICAL SUPPORT TECH OF ACAD OF SYST ENG OF ACAD OF MILITARY SCI
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