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System, method, device and storage medium for determining immune age

A technology of memory and immune cells, applied in patient-specific data, health index calculation, medical informatics, etc.

Active Publication Date: 2021-05-14
广州市雷德医学检验实验室有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The embodiment of the present invention provides a system, method, device and storage medium for determining immune age, which solves the problem that the immune status detection technology in the prior art cannot obtain the health degree of the immune system of the subject

Method used

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  • System, method, device and storage medium for determining immune age
  • System, method, device and storage medium for determining immune age
  • System, method, device and storage medium for determining immune age

Examples

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Embodiment 1

[0036] An embodiment of the present invention provides an immune age determination system. like figure 1 As shown, the system includes a memory 102, a processor 101, and a computer program stored in the memory 102 and executable on the processor. like figure 2 As shown, the processor implements the following steps when executing a computer program:

[0037] S101. Receive the chronological age of the subject and preset index data of at least three preset immune cell subsets.

[0038] Wherein, the temporal age is a biological age of a person or a biological age group. Since the immune status of a person will change with the health status and / or physiological age of the body, when determining the immune status of the subject, it is necessary to use the dimensions of the subject's time and age according to its various presets. Preset indicator data of immune cell subsets to determine their health.

[0039] Wherein, the preset immune cell subsets are immune cell subsets clini...

Embodiment 2

[0072] Image 6It is a flow chart of the method for determining immune age provided in Example 2 of the present invention. The technical solution of this embodiment is applicable to the situation where the immune age of the subject is determined according to the preset index data and chronological age of at least three preset immune cell subsets. The method can be executed by the immune age determination device provided in the embodiment of the present invention, and the device can be implemented in the form of software and / or hardware, and configured to be applied in a processor of the immune age determination system. The method specifically includes the following steps:

[0073] S201. Receive the chronological age of the subject and preset index data of at least three preset immune cell subsets.

[0074] Wherein, the temporal age is a biological age of a person or a biological age group. Since the immune status of a person will change with the health status and / or physiol...

Embodiment 3

[0086] On the basis of the above-mentioned embodiments, the embodiments of the present invention further illustrate the immune age model, specifically the establishment of the immune age model. like Figure 7 As shown, the establishment method of immune age model includes:

[0087] S301. Establish a correlation equation between preset index data of each cell subset of T lymphocytes and time age.

[0088] Collect blood samples of 2-3ml from target subjects of different ages. Transport at room temperature and complete sample analysis within 24-48 hours. During sample analysis, blood samples are labeled with reagents that can detect immune cell subsets or the status of cell surface markers, such as: anti-human CD3 + -FITC, anti-human CD4 + -PerCP, anti-human CD8 + -PE, anti-human CD28 + -APC-R700 antibody, etc. The used markers are detected by a flow cytometry instrument to obtain preset index data of each immune cell subgroup, such as the percentage or absolute quantity o...

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Abstract

The embodiment of the present invention discloses a system, method, device, and storage medium for determining immune age. The system includes: a memory, a processor, and a computer program stored in the memory and operable on the processor. The processor executes The computer program implements the following steps: receiving the chronological age of the subject and preset index data of at least three preset immune cell subgroups; inputting the received chronological age and preset index data into the immune age module to obtain the subject immune age; wherein, the immune age module is used to determine the evaluation index data of each cell subgroup according to the corresponding relationship between the time age and the preset index data of each preset immune cell subgroup, and based on each The evaluation index data of individual cell subsets and the immune age model are used to determine the immune age of the subject. The invention solves the problem that the immune state detection technology in the prior art cannot obtain the health degree of the immune system of the subject.

Description

technical field [0001] Embodiments of the present invention relate to the field of medical equipment, and in particular to a system, method, device and storage medium for determining immune age. Background technique [0002] T lymphocytes are derived from pluripotent stem cells of the bone marrow. During the embryonic and nascent stages of the human body, a part of pluripotent stem cells or pre-T lymphocytes in the bone marrow migrate into the thymus, differentiate and mature under the induction of thymus hormones, and become immune-active T lymphocytes. Mature T lymphocytes are distributed to the thymus-dependent area of ​​peripheral immune organs to settle in the thymus-dependent area through the blood flow, and can recirculate through lymphatic vessels, peripheral blood and tissue fluid, etc., and exert functions such as cellular immunity and immune regulation. The recirculation of T lymphocytes is conducive to extensive exposure to antigenic substances entering the body...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16H50/30G16H10/60
CPCG16H10/60G16H50/30
Inventor 喻韶华罗新根楼建荣
Owner 广州市雷德医学检验实验室有限公司
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