Purpose of neuronal guidance factor semaphorin 3a for preparing medicine capable of treating osteoarthritis

A technology of guiding factor and osteoarthritis, which is applied in the field of preparation of osteoarthritis drugs, can solve the problem of being unable to inhibit the process of OA, and achieve the effects of inhibiting the process, good therapeutic effect, promoting cartilage hyperplasia and increasing the gap

Active Publication Date: 2020-02-11
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Although it has effects such as pain relief, anti-inflammatory properties, joint range of motion (ROM) improvement, and no serious adverse drug reactions, ...

Method used

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  • Purpose of neuronal guidance factor semaphorin 3a for preparing medicine capable of treating osteoarthritis
  • Purpose of neuronal guidance factor semaphorin 3a for preparing medicine capable of treating osteoarthritis
  • Purpose of neuronal guidance factor semaphorin 3a for preparing medicine capable of treating osteoarthritis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0033] Therapeutic effect of experimental example 1SEMA on mouse knee arthritis

[0034] 1. Experimental method

[0035] 1.1 Knee arthritis model

[0036] Animals: 8-week-old C57 mice.

[0037] Right leg ACLT: Anterior cruciate ligament transection.

[0038] Experimental equipment and reagents: surgical instruments for animal experiments (ophthalmological scissors, tweezers, etc.), animal experiment boards, 1% sodium pentobarbital, povidone iodine, normal saline, 75% alcohol, gauze.

[0039] Experimental principle: simulate traumatic knee arthritis.

[0040] Experimental procedure: according to the dose of 0.3-0.6ml / 100g, intraperitoneal injection of pentobarbital sodium anesthetizes the mice, and puts them back into the cage after comforting the mice. The front and rear feet are fixed on the experimental platform, and the right leg is not fixed. After disinfecting the knee joint of the right leg with povidone iodine, carefully cut open and expose the joint, find the ante...

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Abstract

The invention provides a purpose of a neuronal guidance factor semaphorin 3a for preparing a medicine capable of treating osteoarthritis. The invention also provides a new medicine for treating the osteoarthritis, and the medicine takes the semaphorin 3a as an active ingredient. A ratio of cartilages on an osteoarthritis position can be improved to realize the effective treatment of the osteoarthritis, and a course of the osteoarthritis can be reversed. The purpose has a good application prospect.

Description

technical field [0001] The invention relates to the field of medicine preparation for osteoarthritis. Background technique [0002] Osteoarthritis (OA) is a degenerative disease, which is caused by aging, obesity, strain, trauma, congenital abnormalities of joints, joint deformities and many other factors. , Also known as osteoarthritis, degenerative arthritis, senile arthritis, hypertrophic arthritis, etc. Clinical manifestations include slowly developing joint pain, tenderness, stiffness, joint swelling, limited mobility, and joint deformity. [0003] Currently, drugs for the treatment of osteoarthritis mainly include oral and topical non-steroidal anti-inflammatory drugs (NSAIDs), as well as hyaluronic acid and steroid preparations for intra-articular injection. [0004] However, oral nonsteroidal anti-inflammatory drugs (NSAIDs) often cause gastrointestinal problems (especially in elderly patients), and long-term use is often accompanied by abnormal kidney, liver and o...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P19/02A61P29/00A61P19/04A61P19/08
CPCA61K38/1709A61P19/02A61P29/00A61P19/04A61P19/08
Inventor 黄石书周宗科吴迪伟杨帆王立平高大双
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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