Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Imidacloprid and moxidectin dihydric alcohol plastid and preparation method and application thereof

A technology of dihydric alcohol and imidacloprid, which is applied in the field of imidacloprid and moxidectin diol plastids and their preparation, can solve the problems of ineffective treatment effect, achieve longer effective action time, longer action time, and improve transdermal effect of depth

Inactive Publication Date: 2020-02-11
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
View PDF6 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are three main dosage forms of pet deworming preparations: transdermal agent, oral agent and injection. Transdermal agents are often used clinically. This preparation has the characteristics of simple operation and convenient use, but the therapeutic effect is not obvious

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Imidacloprid and moxidectin dihydric alcohol plastid and preparation method and application thereof
  • Imidacloprid and moxidectin dihydric alcohol plastid and preparation method and application thereof
  • Imidacloprid and moxidectin dihydric alcohol plastid and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0033] In another aspect of the present invention, a kind of preparation method of imidacloprid and moxidectin diol plastid is proposed, comprising the following steps:

[0034] (1) Weigh imidacloprid, moxidectin, soybean lecithin, glycol (ethanol: propylene glycol = 7:3) and polysorbate-80 according to the formula described in any of the above, and stir until dissolved in an airtight manner, and cool to room temperature;

[0035] (2) Add phosphate buffer solution dropwise, stir, and cool to room temperature;

[0036] (3) Ultrasound to obtain nano-alcoholsomes;

[0037] (4) Filtrate to obtain the plastid of imidacloprid and moxidectin glycol.

[0038] Preferably, the stirring temperature in step (1) is 29.5-30.5° C., and the stirring speed is 600-800 rpm; the dropping speed in step (2) is 3-6 mL / min; the pH of the phosphate buffer is 6.5-7.0; stirring for 20-30 min.

[0039] Preferably, step (3) ultrasonic power 100~120W, frequency 45~50kHz; ultrasonic 3~4s, interval 3~4s, ...

Embodiment 1

[0045]A glycol plastid of imidacloprid and moxidectin, comprising the following components in parts by weight: 5.0 parts of imidacloprid; 1 part of moxidectin; 2.0 parts of soybean lecithin; 30.0 parts of glycol (ethanol:propylene glycol=7:3) parts; polysorbate-80, 0.5 parts and phosphate buffer (pH=6.5) 61.5 parts. (take the total amount of 100ml as an example)

[0046] A preparation method of imidacloprid and moxidectin glycol plastid:

[0047] (1) Weigh imidacloprid, moxidectin, soybean lecithin, glycol (ethanol: propylene glycol = 7:3), polysorbate-80 into the reaction tank according to the proportion, the stirring temperature is 30 ℃, and the stirring speed is 700rpm , stirred until dissolved;

[0048] (2) Then add phosphate buffer solution (pH=6.5) at a drop rate of 4mL / min, stir in a closed container for 20 minutes until completely dissolved, and cool to room temperature;

[0049] (3) Under ultrasonic power 100W and ultrasonic frequency 45kHz, ultrasonic 3s, interval...

Embodiment 2

[0053] A glycol plastid of imidacloprid and moxidectin, comprising the following components in parts by weight: 8.0 parts of imidacloprid; 2 parts of moxidectin; 2.5 parts of soybean lecithin; 32.0 parts of glycol (ethanol:propylene glycol=7:3) parts; polysorbate-80, 0.5 parts; phosphate buffer (pH=6.5) 55 parts. (take the total amount of 100ml as an example)

[0054] A preparation method of imidacloprid and moxidectin glycol plastid:

[0055] (1) Weigh imidacloprid, moxidectin, soybean lecithin, glycol (ethanol: propylene glycol = 7:3), polysorbate-80 into the reaction tank according to the proportion, the stirring temperature is 30 ℃, and the stirring speed is 700rpm , stirred until dissolved;

[0056] (2) Then add phosphate buffer solution (pH=6.5) at a drop rate of 4mL / min, stir in a closed container for 20 minutes until completely dissolved, and cool to room temperature;

[0057] (3) Under ultrasonic power 100W and ultrasonic frequency 45kHz, ultrasonic 3s, interval 3s...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses an imidacloprid and moxidectin dihydric alcohol plastid and a preparation method and application thereof. An insect repellent preparation is prepared from the following components: imidacloprid, moxidectin, soybean lecithin, dihydric alcohol (including ethanol and propylene glycol), polysorbate-80 and a phosphate buffer solution. It is confirmed by animal experiments that the imidacloprid and moxidectin dihydric alcohol plastid preparation has the effect of resisting in-vivo and in-vitro parasite infection in dogs and cats. Meanwhile, compared with an imidacloprid and moxidectin compound transdermal agent, the toxicity of the imidacloprid and moxidectin dihydric alcohol plastid preparation is greatly reduced, and the advantages such as good skin permeability, biologically slow release, longer action time and comparatively excellent treatment effect are achieved.

Description

technical field [0001] The invention belongs to the field of insect control, and in particular relates to a plastid of imidacloprid and moxidectin glycol, a preparation method and application thereof. Background technique [0002] Pets are friends of human beings, and raising pets has become a leisure way for many families. In recent years, the number of pets kept in my country has been increasing, mainly dogs and cats. With the increase of the number of pets, a series of problems such as pet diseases and so on are produced. Most pet diseases are caused by internal and external parasitic diseases, which have attracted people's attention. There are many kinds of pet parasites. Among them, Toxocara is an important nematode that parasitizes dogs and cats. It can cause animal visceral and eye larval migratory diseases, and it is also a zoonotic parasitic disease. [0003] The external parasites of dogs and cats, such as mites, fleas, and lice, have a high infection rate, whic...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K31/4439A61K9/127A61K47/02A61K47/10A61K47/24A61K47/26A61P33/00A61P33/10A61P33/14
CPCA61K31/4439A61K31/365A61K9/1271A61K47/24A61K47/10A61K47/26A61K47/02A61P33/00A61P33/10A61P33/14A61K2300/00
Inventor 孙铭飞廖申权戚南山吕敏娜吴彩艳李娟林栩慧胡俊菁蔡海明于林增肖文婉
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com