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Injectable high-strength composite hydrogel based on colloidal particle-iPRF double network structure, and preparation method and application thereof

A technology of compounding hydrogels and colloidal particles, which is applied in the directions of inactive components of polymer compounds, prostheses, and liquid transportation, can solve the problems of short degradation period, limited regeneration potential, poor mechanical strength of materials, etc. volume increase effect

Active Publication Date: 2020-02-07
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above materials still have the following defects: 1. PRP contains exogenous additives such as anticoagulants, and its regenerative potential is limited; 2. The mechanical strength of the obtained material is poor, and it is not injectable, and the operation is complicated and difficult to be precise. Quantify
However, the degradation period of iPRF is short after implantation, and the growth factor components that induce regeneration are also quickly degraded and inactivated. Therefore, although iPRF has good biological activity and regenerative function, it is still difficult to achieve long-term, controllable factor Release and induce regeneration are limited

Method used

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  • Injectable high-strength composite hydrogel based on colloidal particle-iPRF double network structure, and preparation method and application thereof
  • Injectable high-strength composite hydrogel based on colloidal particle-iPRF double network structure, and preparation method and application thereof
  • Injectable high-strength composite hydrogel based on colloidal particle-iPRF double network structure, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] (1) Different sizes of silica and iprf

[0045] Commercially available silica nanoparticles with a particle size of 100,500 nm (purchased from Sigma Chemical Co., Ltd.) were used. The potential of the particles obtained by testing with a nanometer particle size analyzer is -30mV.

[0046] (2) Positive electrochemistry of silicon dioxide

[0047] Weigh 24g of purchased 100,500nm silica, disperse it into 600mL of ethanol, ultrasonically disperse for 15min, and prepare a 15mg / mL silica suspension. Place it in a water bath at 40°C, add 3 mL of silane coupling agent APTMS within 20 minutes using a syringe pump, and stir at 1000 rpm. Subsequently, the reaction was carried out at 40° C. for 5 h. After the reaction, ethanol (1 time), ethanol-water (1 time), and water (4 times) were used to centrifuge and then disperse the cleaning particles for 6 times to prepare positively charged silica nanoparticles. The potential of the particles obtained by testing with a nanometer par...

Embodiment 2

[0055] (1) Different proportions of silica

[0056] Commercially available silica nanoparticles with a particle size of 100,500 nm (purchased from Sigma Chemical Co., Ltd.) were used. The potential of the particles obtained by testing with a nanometer particle size analyzer is -30mV.

[0057] (2) Positive electrochemistry of silicon dioxide

[0058] Weigh 24g of purchased 100,500nm silicon dioxide, disperse it into 600mL of ethanol, ultrasonically disperse for 15min, and prepare a 15mg / mL silicon dioxide suspension. Place it in a water bath at 40°C, add 3 mL of silane coupling agent APTMS within 20 minutes using a syringe pump, and stir at 1000 rpm. Subsequently, the reaction was carried out at 40° C. for 5 h. After the reaction, ethanol (1 time), ethanol-water (1 time), and water (4 times) were used to centrifuge and redisperse the cleaning particles for 6 times to prepare positively charged silica nanoparticles. The potential of the particles obtained by testing with a n...

Embodiment 3

[0066] (1) Different sizes of silica and iprf

[0067] Commercially available silica nanoparticles with a particle size of 100,500 nm (purchased from Sigma Chemical Co., Ltd.) were used. The potential of the particles obtained by testing with a nanometer particle size analyzer is -30mV.

[0068] (2) Positive electrochemistry of silicon dioxide

[0069] Weigh 24g of purchased 100,500nm silicon dioxide, disperse it into 600mL of ethanol, ultrasonically disperse for 15min, and prepare a 15mg / mL silicon dioxide suspension. Place it in a water bath at 40°C, add 3 mL of silane coupling agent APTMS within 20 minutes using a syringe pump, and stir at 1000 rpm. Subsequently, the reaction was carried out at 40° C. for 5 h. After the reaction, ethanol (1 time), ethanol-water (1 time), and water (4 times) were used to centrifuge and redisperse the cleaning particles for 6 times to prepare positively charged silica nanoparticles. The potential of the particles obtained by testing with ...

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Abstract

The invention relates to the technical field of biomedical materials, in particular to an injectable high-strength composite hydrogel based on a colloidal particle-iPRF double network structure, and apreparation method and application thereof. Nano-colloidal particles in the composite hydrogel with the double-network structure are assembled under physical action such as electrostatic interactionto form a first colloidal gel network, injectable platelet-rich fibrin (iPRF) forms a second fibrin hydrogel network, and the two gel networks are physically crosslinked by electrostatic action, hydrogen bond action and hydrophobic action to form the hydrogel with the double network structure. Fresh blood samples are added with no anticoagulant drugs, low-speed centrifugation operation is carriedout, all yellow liquid at the top layer is taken to be quickly blended with colloidal particle dry powder, and complete curing is finished after curing at room temperature or body temperature for no more than 2000 seconds. According to the invention, the composite hydrogel with the double network structure is an ideal recyclable injectable moldable biomedical material.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an injectable, high-strength composite hydrogel based on a colloid particle-iPRF double network structure and its preparation method and application. Background technique [0002] Achieving damage repair of human tissues / organs is a key problem in clinical medicine. However, autologous tissue, allogeneic tissue or xenogeneic tissue is still the main method for clinical treatment of human tissue / organ repair. Taking bone repair as an example, the clinical "golden" treatment standard for bone repair is the patient's autologous bone graft filling. Since there is no immune rejection of autologous tissues / organs and they are usually well vascularized, the repair effect is remarkable. For example, the best clinical bone repair plan for bone defect is to take bone from the patient's own iliac crest and transplant it to the patient's bone defect site; although this plan ha...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L89/00C08K3/36C08L5/08A61K9/06A61K47/42A61L27/52A61L27/44A61L27/48A61L27/50
CPCC08J3/075A61K9/06A61K47/42A61L27/52A61L27/446A61L27/48A61L27/507C08J2389/00C08K3/36C08J2305/08A61L2430/02A61L2430/06A61L2430/30
Inventor 王华楠陈楷文
Owner DALIAN UNIV OF TECH
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