Application of dioscin to preparation of medicines for treating Alzheimer's diseases

A technology for Alzheimer's disease and diosgenin, which is applied in the field of application of diosgenin in the preparation of drugs for treating Alzheimer's disease, and can solve the problems of no diosgenin, etc.

Inactive Publication Date: 2020-02-07
DALIAN MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there are no relevant reports on the application of diosgenin in the treatment of Alzheimer's disease

Method used

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  • Application of dioscin to preparation of medicines for treating Alzheimer's diseases
  • Application of dioscin to preparation of medicines for treating Alzheimer's diseases
  • Application of dioscin to preparation of medicines for treating Alzheimer's diseases

Examples

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Effect test

Embodiment 1

[0016] Example 1 Study on the therapeutic effect of diosgenin on Alzheimer's disease

[0017] The Alzheimer's disease animal model used in this example is the SAM (Senescence-accelerated mouse) mouse, which is a rapid aging mouse bred from the common genetic group AKR / J mouse in the 1980s through phenotypic selection. model. These include the rapidly aging P series (Senescence-accelerated prone mouse, SAMP) and the anti-rapid aging R series (Senescence-accelerated resistant mouse, SAMR). The Alzheimer's disease model used in this example is SAMP8 mice, and SAMR1 mice are used as normal controls. The physiological indicators and survival period of SAMR1 are similar to those of normal mice. In contrast, the learning and memory impairment related to aging shown by SAMP8 is very similar to the clinical manifestations of Alzheimer's disease. The central nervous system such as Pathological changes mainly occurred in cortex, hippocampus and other parts. In addition, behavior, morph...

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Abstract

The invention discloses an application of dioscin to preparation of medicines for treating Alzheimer's diseases. The Morris water maze testing result shows that a dioscin administration group can shorten the escaping latency period, prolong original platform quadrant residence time and increase the number of times of passing through a platform, which indicates that the dioscin can significantly improve the spatial learning and memorizing capacity of AD mice; the gait analysis result indicates that the dioscin can significantly increase the gait indexes of the AD mice, and strengthen the physical strength of the AD mice, so that the movement velocity of the AD mice is accelerated, the stride frequency is increased, the stepping length is increased and the duty cycle can be significantly shortened; the dioscin can significantly reduce the MDA level in hippocampal tissue of the AD mice, increase the GSH level and the SOD level, and improve oxidative damage of brain tissue of the AD mice;and the dioscin can restrain AchE activity of the hippocampal tissue, increase ChAT level, influence a cholinergic system, obviously improve the pathology structure of the brain tissue of the AD miceand ultrastructural damage of nerve cells. The dioscin can be used as a single effective component to be prepared into medicines, and can be combined with other medicines for preparing a compound preparation.

Description

technical field [0001] The invention relates to a new application of active ingredients of traditional Chinese medicine, in particular to the application of high-purity diosgenin in the preparation of drugs for treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is a degenerative neurological disease of unknown cause, manifested as intellectual and cognitive decline and behavior and personality changes, and is the most common form of senile dementia. Alzheimer's disease is prone to occur in people over 65 years old, and the incidence rate increases with age. With the aging of the world's population, Alzheimer's disease is developing at an alarming rate. According to the "World Alzheimer's Disease Report 2016" released by Alzheimer's Disease International (ADI), there are currently more than 47 million Alzheimer's patients worldwide, and it is expected that by 2050 there will be more than 131 million people, and by 2018 The annual global cost...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K45/06A61P25/28
CPCA61K31/7048A61K45/06A61P25/28
Inventor 彭金咏齐艳尹连红许丽娜赵艳艳孙鹏远许有威韩旭李磊
Owner DALIAN MEDICAL UNIVERSITY
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