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Preparation method of azelaic acid supramolecules

A kind of azelaic acid and supramolecular technology, applied in the field of supramolecular chemistry, can solve the problem of less azelaic acid and the like, and achieve the effects of treating acne, improving compatibility and increasing stability

Inactive Publication Date: 2020-01-10
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are few reports on the application of azelaic acid in cosmetics in the existing literature, and it mainly exists as azelaic acid derivative (K-ADG), which is a potassium salt prepared by reacting azelaic acid with amino acids

Method used

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  • Preparation method of azelaic acid supramolecules
  • Preparation method of azelaic acid supramolecules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A supermolecule of azelaic acid, molecular recognition is carried out by azelaic acid, polyethylene glycol-400, and propylene glycol, calculated according to the mass ratio, wherein the ratio of azelaic acid: polyethylene glycol-400: propylene glycol is 0.4:15:5.25.

[0030] The preparation method of described azelaic acid supramolecular comprises:

[0031] (1) Measure 11.8mL of polyethylene glycol-400 (15g) and 5mL of 1,3-propanediol (5.25g) in a beaker, mix them, and stir at 600r / min for 8min to obtain a mixed solvent.

[0032] (2) Weigh 0.4 g of azelaic acid and dissolve it in the above solvent, and stir in a constant temperature water bath at 50° C. at 500 r / min for 15 min to form an azelaic acid solution.

[0033] (3) Measure 100 mL of deionized water into a beaker and heat to 98°C. Stir at a speed of 600r / min, and dropwise add the azelaic acid solution to the above-mentioned deionized water at a speed of 1mL / min. The dropping temperature of the azelaic acid solut...

Embodiment 2

[0036] A supermolecule of azelaic acid, molecular recognition is carried out by azelaic acid, polyethylene glycol-400, and propylene glycol, calculated according to the mass ratio, wherein the ratio of azelaic acid: polyethylene glycol-400: propylene glycol is 0.6:15:6.3.

[0037] (1) Measure 11.8mL of polyethylene glycol-400 (15g) and 6mL of 1,3-propanediol (6.3g) in a beaker, mix them, and stir at 600r / min for 8min to obtain a mixed solvent.

[0038] (2) Weigh 0.6 g of azelaic acid and dissolve it in the above solvent, and stir in a constant temperature water bath at 50° C. at 500 r / min for 15 min to form an azelaic acid solution.

[0039] (3) Measure 100 mL of deionized water into a beaker and heat to 98°C. Stir at a speed of 600r / min, and dropwise add the azelaic acid solution to the above-mentioned deionized water at a speed of 1mL / min. The dropping temperature of the azelaic acid solution is 50°C. Continue to stir at a constant speed for 2 hours to obtain supramolecular...

Embodiment 3

[0042] A supermolecule of azelaic acid, molecular recognition is carried out by azelaic acid, polyethylene glycol-400, and propylene glycol, calculated according to the mass ratio, wherein the ratio of azelaic acid: polyethylene glycol-400: propylene glycol is 0.8:15:7.35.

[0043] (1) Measure 11.8mL of polyethylene glycol-400 (15g) and 7mL of 1,3-propanediol (7.35g) in a beaker, mix them, and stir at 600r / min for 8min to obtain a mixed solvent.

[0044] (2) Weigh 0.8 g of azelaic acid and dissolve it in the above solvent, and stir in a constant temperature water bath at 50° C. at 500 r / min for 15 min to form an azelaic acid solution.

[0045] (3) Measure 100 mL of deionized water into a beaker and heat to 98°C. Stir at a speed of 600r / min, and dropwise add the azelaic acid solution to the above-mentioned deionized water at a speed of 1mL / min. The dropping temperature of the azelaic acid solution is 50°C. Continue to stir at a constant speed for 2 hours to obtain supramolecul...

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Abstract

The invention discloses a preparation method of azelaic acid supermolecules, which is characterized by comprising the following steps: mixing polyethylene glycol and propylene glycol to obtain a mixedsolvent; weighing and dissolving azelaic acid in the mixed solvent to form an azelaic acid solution; putting deionized water into a reaction container; heating to 95-100 DEG C, stirring at the rotating speed of 400 to 700r / min; dropwise adding the azelaic acid solution into deionized water at the speed of 0.5 to 1mL / min, controlling the dropwise adding temperature of the azelaic acid solution tobe 48 to 60 DEG C, and continuously stirring for 1.5 to 2.5 hours at the rotating speed of 400 to 700r / min after dropwise adding is finished, so as to obtain the azelaic acid supramolecule. The azelaic acid supermolecules are high in stability and good in solubility, can effectively solve the problems of poor stability and poor solubility of azelaic acid, are beneficial to storage, and can fully utilize azelaic acid resources to play a greater role in skin care and beauty.

Description

technical field [0001] The invention belongs to the field of supramolecular chemistry, and specifically relates to a supramolecule with the effects of whitening, acne and freckle. Background technique [0002] Azelaic acid, also known as azelaic acid, is a naturally occurring natural straight-chain saturated carboxylic acid containing 9 carbon atoms. It is an important chemical raw material and has high value in skin care, cosmetics, and prevention and treatment of skin diseases. It can competitively inhibit tyrosinase, whiten skin, and remove stains; another use is antibacterial, azelaic acid can inhibit protein synthesis of cells, and can inhibit Staphylococcus, Propionibacterium acnes, Escherichia coli, etc. In addition, azelaic acid can inhibit the secretion of free fatty acids in the sebaceous glands and regulate the normal secretion of sebum, so it can also be used to treat acne. However, due to its poor compatibility, poor water solubility, easy to change color, it i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00A61K8/362A61K8/86A61K8/34A61Q19/02A61Q17/00A61P17/10A61P31/04
CPCA61K8/345A61K8/362A61K8/86A61K2800/592A61K2800/782A61Q17/005A61Q19/02A61P17/10A61P31/04C08G83/008
Inventor 宋晓秋徐亚杰叶琳
Owner SHANGHAI INST OF TECH
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