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W/O/W type multiple emulsion and preparation method thereof

A multi-emulsion, total weight technology, applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of difficulty in preparing multiple emulsions for long-term stable storage, complex and changeable cosmetics, etc. properties, improve the formation rate and stability, and reduce the effect of interfacial tension

Active Publication Date: 2020-01-03
瑞希(重庆)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main reason is that the cosmetic formula is complex and changeable, and it is difficult to prepare multiple emulsions that can be stored stably for a long time

Method used

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  • W/O/W type multiple emulsion and preparation method thereof
  • W/O/W type multiple emulsion and preparation method thereof
  • W/O/W type multiple emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of W / O / W type multiple emulsion, by weight percentage, this multiple emulsion comprises following components: hydrophilic surfactant (sodium lauryl sulfate 0.5%, Tween 80 1%) 1.5%, hydrophilic Oily surfactant (decaglyceryl decaoleate) 1%, active ingredient (sunscreen agent [bis-ethylhexyloxyphenol methoxyphenyl triazine]) 3%, acceptable excipients in skin external preparations (oil Phase [paraffin] 3%, stabilizer [polyvinyl alcohol] 0.75%, antioxidant [tocopheryl acetate] 0.5%, preservative [propylparaben] 1%) 5.25%, the balance is purified water. The multiple emulsion was prepared as follows:

[0025] (1) According to the percentage by weight of each component in the above-mentioned multiple emulsion, take hydrophilic surfactant (sodium lauryl sulfate, Tween 80), lipophilic surfactant (decaglyceryl decaoleate) , active ingredient (sunscreen agent [bis-ethylhexyloxyphenol methoxyphenyl triazine]), acceptable excipients in external skin preparations (oil phase [...

Embodiment 2

[0028] A kind of W / O / W type multiple emulsion, by weight percentage, this multiple emulsion comprises following components: hydrophilic surfactant (1% sodium lauryl sulfate, Tween 80 2%) 3%, hydrophilic Oily surfactant (ten polyglycerol decaoleate) 2%, active ingredient (whitening and anti-freckle agent [methoxy salicylate potassium]) 3%, acceptable excipients in skin external preparations (oily phase [tetradecanoic acid] Isopropyl ester] 5%, stabilizer [polyvinyl alcohol] 1%, antioxidant [sodium metabisulfite] 2.5%, preservative [phenoxyethanol] 1%) 9.5%, and the balance is purified water. The multiple emulsion was prepared as follows:

[0029] (1) According to the percentage by weight of each component in the above-mentioned multiple emulsion, take hydrophilic surfactant (sodium lauryl sulfate, Tween 80), lipophilic surfactant (decaglyceryl decaoleate) , active ingredient (whitening and anti-freckle agent [potassium methoxysalicylate]), acceptable excipients in external ski...

Embodiment 3

[0032] A kind of W / O / W type multiple emulsion, by weight percentage, this multiple emulsion comprises following components: hydrophilic surfactant (sodium lauryl sulfate 0.8%, Tween 80 1.6%) 2.4%, hydrophilic Oily surfactant (ten polyglycerol decaoleate) 1.6%, active ingredient (whitening and anti-freckle agent [ethyl ascorbic acid] 5%, anti-aging agent [tea polyphenol] 10%) 15%, acceptable in external skin preparations Excipients (oil phase [paraffin] 4%, stabilizer [sodium polymethacrylate] 0.5%, antioxidant [tocopherol] 1%, preservative [sorbitol] 1%) 6.5%, the balance is purified water . The multiple emulsion was prepared as follows:

[0033] (1) According to the percentage by weight of each component in the above-mentioned multiple emulsion, take hydrophilic surfactant (sodium lauryl sulfate, Tween 80), lipophilic surfactant (decaglyceryl decaoleate) , active ingredients (whitening and anti-freckle agent [ethyl ascorbic acid], anti-aging agent [tea polyphenol]), accepta...

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Abstract

The invention relates to a W / O / W type multiple emulsion and a preparation method thereof, and belongs to the technical field of cosmetics. The multiple emulsion is prepared form the following components in percentage by weight: 1.5%-3% of a hydrophilic surfactant, 1%-2% of a lipophilic surfactant, 0.1%-20% of active ingredients, 2.1%-26% of acceptable excipients in a skin external preparation andthe balance of water. The multiple emulsion is prepared by a two-step emulsification method, during the preparation process, by properly controlling the types and dosage of the hydrophilic surfactantand the lipophilic surfactant, the HLB value of the prepared multiple emulsion can be finally controlled, the generation rate and stability of the final prepared multiple emulsion system can be effectively improved, the oil layer area after long-term storage is not changed. The multiple emulsion preparation method is simple and low in cost, and is suitable for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a W / O / W type multiple emulsion and a preparation method thereof. Background technique [0002] There are only two types of traditional emulsions, O / W type and W / O type. W / O type emulsion has a bright appearance, good moisturizing and emollient effect, but it is easy to stick when applied, the skin feels poor, and it is not easy to clean; while O / W type emulsion has good spreadability and refreshing effect. Skin feel, but the moisturizing effect and emollient effect are not as good as W / O emulsion. [0003] Multiple emulsions, also known as composite emulsions, referred to as multiple emulsions, are multi-layer emulsions formed by dispersing one emulsion (often called primary emulsion, referred to as colostrum) in another continuous phase. Generally, they are highly dispersed and have different particle sizes. There are many types of multi-phase systems, and the tw...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/06A61K8/39A61K8/46A61K8/49A61K8/31A61K8/81A61K8/67A61K8/37A61Q19/00
CPCA61K8/066A61K8/39A61K8/463A61K8/4993A61K8/4966A61K8/31A61K8/8129A61K8/678A61K8/37A61Q19/00A61K2800/592A61K2800/805
Inventor 冯文学李杨洪
Owner 瑞希(重庆)生物科技有限公司
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