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Egg yolk antibody composition and application thereof in preparation of product for preventing and treating gastrointestinal diseases

A gastrointestinal disease, yolk antibody technology, applied in the preparation of products for the prevention and treatment of gastrointestinal diseases, in the field of yolk antibody composition, can solve problems such as poor curative effect and complexity, and achieve the effect of reducing the risk of gastrointestinal diseases

Pending Publication Date: 2019-12-13
北京宇诚健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But not only does this approach kill large numbers of beneficial bacteria, but the spread of antibiotic resistance is complicating the treatment of this bacterial infection
In the prior art, the anti-helicobacter pylori infection drugs have poor efficacy and need to be solved urgently
[0004] In addition, with the improvement of people's living standards, the requirements for the quality of life are getting higher and higher, and the demand for ensuring the health of children is getting higher and higher, and the infection of Helicobacter pylori often occurs in infants and young children. use more cautiously

Method used

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  • Egg yolk antibody composition and application thereof in preparation of product for preventing and treating gastrointestinal diseases
  • Egg yolk antibody composition and application thereof in preparation of product for preventing and treating gastrointestinal diseases
  • Egg yolk antibody composition and application thereof in preparation of product for preventing and treating gastrointestinal diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] 1. The preparation process of egg yolk antibody is as follows:

[0057] Laying hens were immunized with Helicobacter pylori serine protease, Helicobacter pylori outer membrane protein, Helicobacter pylori whole bacteria and Helicobacter pylori broken bacteria respectively. After the three immunizations, the eggs were collected and the egg yolk antibody was extracted by the three-step method of polyethylene glycol, and then purified by the two-step method of ammonium sulfate. The purified yolk antibody obtained after purification is desalinated and sterilized by ultrafiltration, and finally freeze-dried by freeze-drying to obtain yolk antibody freeze-dried powder.

[0058] The specific process of extracting yolk antibody from egg yolk liquid is as follows: figure 1 As shown, specifically:

[0059] The Helicobacter pylori serine protease egg yolk antibody, the Helicobacter pylori outer membrane protein egg yolk antibody, the whole Helicobacter pylori egg yolk antibody, ...

Embodiment 2

[0077] This embodiment provides a kind of egg yolk antibody infant milk powder capable of preventing and treating gastritis, gastric ulcer, gastric cancer and other gastrointestinal problems caused by Helicobacter pylori infection: compound the egg yolk antibody in the following parts by weight: Helicobacter pylori serine protease egg yolk 0.3 part of antibody, 0.25 part of Helicobacter pylori outer membrane protein egg yolk antibody, 0.4 part of Helicobacter pylori whole bacteria egg yolk antibody, and 0.4 part of Helicobacter pylori broken bacteria egg yolk antibody; the obtained egg yolk antibody complex was added to infant milk powder to obtain Infant formula with egg yolk antibody complex.

[0078] In this example, four kinds of yolk antibodies that can effectively prevent and treat Helicobacter pylori infection are compounded to prepare infants with special functions that can be used to solve gastrointestinal diseases such as gastritis, gastric ulcer and even gastric canc...

Embodiment 3

[0080] This embodiment provides a kind of egg yolk antibody infant rice noodle that can prevent and treat gastritis, gastric ulcer, gastric cancer and other gastrointestinal problems caused by Helicobacter pylori infection: compound the egg yolk antibody in the following parts by weight: Helicobacter pylori serine protease egg yolk 0.3 part of antibody, 0.3 part of Helicobacter pylori outer membrane protein yolk antibody, 0.45 part of Helicobacter pylori whole bacterium yolk antibody, and 0.45 part of Helicobacter pylori broken bacteria yolk antibody; Yolk-antibody complexed rice flour for infants and young children.

[0081] In this example, four kinds of egg yolk antibodies that can effectively prevent and treat Helicobacter pylori infection are compounded to prepare infant rice noodles with special functions that can be used to solve gastrointestinal diseases such as gastritis, gastric ulcer and even gastric cancer caused by Helicobacter pylori infection .

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Abstract

The invention provides an egg yolk antibody composition and an application thereof in preparation of a product for preventing and treating gastrointestinal diseases. The egg yolk antibody compositioncomprises a helicobacter pylori serine protease egg yolk antibody, a helicobacter pylori outer membrane protein egg yolk antibody, a helicobacter pylori whole-bacterium egg yolk antibody and a helicobacter pylori broken bacterium egg yolk antibody. The four egg yolk antibodies are compounded, the binding titer of the obtained compound egg yolk antibody and helicobacter pylori is far higher than that of any single egg yolk antibody, the obvious helicobacter pylori infection resisting effect is achieved, and the compound egg yolk antibody can be further applied to various products and can effectively prevent and treat diseases related to helicobacter pylori infection.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a yolk antibody composition and its application in the preparation of products for preventing and treating gastrointestinal diseases. Background technique [0002] Helicobacter pylori, discovered by scientists Barry Marshall and Robin Warren, can infect stomach tissue and cause ulcers. It is estimated that half of the world's population is infected with Helicobacter pylori. And Helicobacter pylori infection usually occurs in childhood, this bacterium is widely distributed, many people are carriers of this bacterium, and may cause Helicobacter pylori infection at some point in life. As a result, it is very likely that the human body will suffer from stomach diseases such as gastritis, gastric ulcer and even gastric cancer. In addition, Helicobacter pylori is also a pathogenic factor of gastric cancer, and the main cause of gastric cancer is considered to be Helicobacter pylori infect...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61P31/04A61P1/04A61P35/00C07K16/40C07K16/12C07K16/02A23L33/17A23L7/10A23F3/14A23C9/152
CPCC07K16/40C07K16/121C07K16/02A61P31/04A61P1/04A61P35/00A23L33/17A23L7/198A23F3/14A23C9/1526A61K2039/507A23V2002/00A23V2200/30A23V2200/32A23V2250/5434
Inventor 赵肃清王甜甜叶远志肖益热陈莉莉
Owner 北京宇诚健康科技有限公司
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