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A kind of composite hydrogel of silk fibroin and polyvinyl alcohol and its preparation method and application

A technology of composite hydrogel and silk fibroin, which is applied in the field of composite hydrogel of silk fibroin and polyvinyl alcohol and its preparation, can solve the problems of limited application range, poor mechanical properties and swelling properties, and achieve material molding Simple method, good hydrophilicity, fast toxicity and side effects

Active Publication Date: 2022-03-29
HUBEI ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pure silk fibroin hydrogels have limited their applications in the biomedical field due to their poor mechanical properties and swelling properties.

Method used

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  • A kind of composite hydrogel of silk fibroin and polyvinyl alcohol and its preparation method and application
  • A kind of composite hydrogel of silk fibroin and polyvinyl alcohol and its preparation method and application
  • A kind of composite hydrogel of silk fibroin and polyvinyl alcohol and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Preparation of silk fibroin: Weigh 3g of anhydrous sodium carbonate and add it to 5L of boiling water solution, put 100-150g of silk into the boiling water solution for degumming and dry at 60°C, after drying, dissolve the silk with ternary solution, Put the solution into a dialysis bag, put it into deionized water for dialysis for 96 hours, change the water every 2 hours during the period, obtain an aqueous silk fibroin solution after dialysis, and finally obtain an aqueous silk fibroin solution with a concentration of 8 wt%.

[0031] (2) Preparation of polyvinyl alcohol solution: Weigh 6-10 g of polyvinyl alcohol (molecular weight is 31000), add 100 ml of deionized water, stir and dissolve in a water bath at 90 ° C, until the concentration after complete dissolution is 6-10 wt % polyvinyl alcohol solution.

[0032] (3) Preparation of a composite hydrogel of silk fibroin and polyvinyl alcohol: get the 8wt% silk fibroin aqueous solution prepared in (1), mix it with ...

Embodiment 2

[0034] Other steps are the same as in Example 1, except that the concentration of polyvinyl alcohol prepared in step (2) is 8 wt%. (3) Add an equal volume of 8wt% polyvinyl alcohol solution. After mixing evenly, add horseradish peroxidase (HRP) and hydrogen peroxide (H 2 o 2 ) for cross-linking, finally obtaining a composite hydrogel of silk fibroin and polyvinyl alcohol.

Embodiment 3

[0036] Other steps are the same as in Example 1, except that the concentration of polyvinyl alcohol prepared in step (2) is 10 wt%. (3) Add an equal volume of 10 wt% polyvinyl alcohol solution. After mixing evenly, add horseradish peroxidase (HPR) and hydrogen peroxide (H 2 o 2 ) for cross-linking, finally obtaining a composite hydrogel of silk fibroin and polyvinyl alcohol.

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Abstract

A composite hydrogel of silk fibroin and polyvinyl alcohol and a preparation method thereof of the present invention can form a hydrogel in a short time, and can effectively improve the hydrophilicity and gel strength of the material, and can be used in sustained drug release. In the field of application, the hydrogel can utilize the dispersing and solubilizing effect of polyvinyl alcohol to load hydrophobic drugs that are difficult to be loaded by the hydrogel, which expands its application range as a drug carrier. The present invention also includes using paeonol as a hydrophobic drug model, and the composite gel of silk fibroin and polyvinyl alcohol as a drug carrier, so that paeonol can be slowly released at a certain rate, which is beneficial to improving the residence time of the drug at the treatment site. Keep the drug concentration in the effective therapeutic concentration range for a long time, improve bioavailability, and achieve the purpose of drug sustained release.

Description

technical field [0001] The invention belongs to the field of hydrogel technology, and in particular relates to a composite hydrogel of silk fibroin and polyvinyl alcohol, a preparation method and application thereof. Background technique [0002] Silk is one of the earliest natural proteins used by humans. As a natural fiber with excellent performance, it is mainly used in the textile industry. Silk is composed of silk fibroin and sericin, and silk fibroin accounts for about 75% of the total weight. The amino acid composition of silk fibroin is mainly glycine, alanine and serine, which is similar to the amino acid composition of collagen in the human body. It has good biocompatibility and can be prepared into various forms of materials such as films, gels, and microcapsules. Among them, silk fibroin hydrogel has broad application prospects in the fields of drug carriers, biomedical materials, and tissue engineering. However, pure silk fibroin hydrogels have limited their a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L89/00C08L29/04A61K9/06A61K47/32A61K47/42A61K31/12A61P31/04A61P31/10A61P29/00A61P35/00A61P37/08
CPCC08J3/075A61K9/06A61K47/32A61K47/42A61K31/12A61P31/04A61P31/10A61P29/00A61P35/00A61P37/08C08J2389/00C08J2429/04C08J2329/04C08J2489/00
Inventor 汪宜宇李祥牛春青王欣宇戴余军张俊华
Owner HUBEI ENG UNIV
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