Composite nanoparticles with tumor targeting and radiotherapy sensitization characteristics, and preparation and application of composite nanoparticles
A composite nanoparticle and tumor-targeting technology, which is applied in the field of composite nanoparticle and its preparation and application, can solve the problems of inaccurate tumor tissue localization diagnosis, accelerate DNA radiation damage repair, reduce the effect of radiotherapy cell killing, etc., and achieve enhanced tumor The effect of local radiation dose, good water dispersibility and biocompatibility, easy implementation and promotion
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Embodiment 1
[0036] This embodiment provides a composite nanoparticle with tumor targeting and radiosensitization properties, wherein the composite nanoparticle includes hyaluronic acid and bismuth trioxide and ceria grown on the hyaluronic acid.
[0037] The mass ratio of hyaluronic acid, bismuth trioxide and ceria in the composite nanoparticles is 50:8:1.
[0038] The method for preparing composite nanoparticles with tumor targeting and radiosensitization properties includes the following steps:
[0039] S1, dissolving bismuth chloride in ultrapure water, vigorously stirring and dissolving to a transparent homogeneous solution, the concentration of obtaining bismuth chloride is 0.02mol / L;
[0040] S2, dissolving sodium hydroxide in ultrapure water, stirring vigorously to dissolve it to a transparent homogeneous solution, and obtaining a concentration of sodium hydroxide of 1 mol / L;
[0041] S3, adding an equal volume of 1 mol / L sodium hydroxide solution to the solution prepared in step ...
Embodiment 2
[0050] In this example, the ability of the composite nanoparticles with tumor targeting and radiosensitization properties prepared in Example 1 to catalyze the decomposition of hydrogen peroxide was measured, and the method was as follows:
[0051] To 0.1 mmol / L hydrogen peroxide solution, different concentrations of the composite nanoparticles with tumor targeting and radiosensitization properties prepared in Example 1 were respectively added, so that the final concentration of cerium in the mixed solution was 0 and 0.05 mmol / L, respectively. L and 0.1 mmol / L, the dissolved oxygen concentration in the mixed solution was measured by a dissolved oxygen analyzer (JPSJ-605F, Thunder Magnetic).
[0052] The results are as figure 2 As shown, the addition of composite nanoparticles with tumor-targeting and radiosensitizing properties resulted in a rapid rise in the dissolved oxygen concentration in the solution, with a higher rate of oxygen generation in the presence of high concen...
Embodiment 3
[0054] In this example, the magnetic resonance imaging contrast ability of the composite nanoparticles with tumor targeting and radiosensitization properties prepared in Example 1 was evaluated in response to acidic pH / hydrogen peroxide, and the method was as follows:
[0055] To pH 5.0, pH 6.5 and pH 7.4 phosphate buffer and pH 5.0, pH 6.5 and pH 7.4 phosphate buffer containing 1 mM hydrogen peroxide, respectively, were added different concentrations of the tumor-targeted tumor-targeting solution prepared in Example 1 The composite nanoparticles with radiosensitizing properties were incubated at 37°C for 4 hours and then subjected to T1-weighted magnetic resonance imaging at a field strength of 7.0T.
[0056] The result is as image 3 As shown in (a), in the absence of hydrogen peroxide, ceria decomposes under acidic conditions to release Ce 4+ , to achieve acidic pH-responsive magnetic resonance imaging contrast.
[0057] The result is as image 3 As shown in (b), in the ...
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