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Fructus mume mouth wash effervescent tablet with a function of accelerating salivary secretion, and preparation method thereof

A technology for promoting saliva secretion and blisters, applied in the field of medicine, can solve the problems of inconvenient portability of mouthwash, few alleviating drugs, poor antibacterial effect, etc. Effect

Inactive Publication Date: 2019-12-03
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solve the problems of few drugs for xerostomia, only suitable for severe patients, inconvenient portability of traditional mouthwash, and poor antibacterial effect

Method used

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  • Fructus mume mouth wash effervescent tablet with a function of accelerating salivary secretion, and preparation method thereof
  • Fructus mume mouth wash effervescent tablet with a function of accelerating salivary secretion, and preparation method thereof
  • Fructus mume mouth wash effervescent tablet with a function of accelerating salivary secretion, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of the ebony gargle effervescent tablet that promotes saliva secretion of embodiment 1

[0038] 1) The effervescent tablet of saliva secretion-promoting ebony mouthwash is made of the following raw materials in parts by weight: 20 parts by weight of citric acid, 5 parts by weight of tartaric acid, 20 parts by weight of sodium carbonate, 2 parts by weight of polyvinylpyrrolidone, 5 parts by weight of polyethylene glycol Diol 6000, 1 part by weight of steviol glycoside, 0.2 part by weight of cross-linked PVP, 0.2 part by weight of peppermint oil, 19 parts by weight of mannitol, 0.05 part by weight of potassium sorbate, 25 parts by weight of ebony extract and 5 parts by weight of gallnut extract.

[0039] 2) Grinding the above-mentioned raw materials through a 160-mesh sieve, and weighing them according to the parts by weight, and set aside.

[0040] 3) Uniformly mix citric acid, tartaric acid, ebony extract, cross-linked PVP, and steviol glycosides, add to...

Embodiment 2

[0043] The preparation of the ebony gargle effervescent tablet that promotes saliva secretion in embodiment 2

[0044]1) The effervescent tablet of saliva secretion-promoting ebony mouthwash is made of the following raw materials in parts by weight: 25 parts by weight of citric acid, 5 parts by weight of fumaric acid, 22 parts by weight of sodium carbonate, 1.5 parts by weight of polyvinylpyrrolidone, and 3.5 parts by weight Polyethylene glycol 6000, 1.5 parts by weight of steviol glycoside, 0.3 parts by weight of cross-linked PVP, 0.3 parts by weight of peppermint oil, 15 parts by weight of mannitol, 0.06 parts by weight of potassium sorbate, 20 parts by weight of ebony extract and 5 parts by weight of gallnut extract things.

[0045] 2) Grind the above-mentioned raw materials through a 170-mesh sieve, weigh them according to the parts by weight, and set aside.

[0046] 3) Uniformly mix citric acid, fumaric acid, ebony extract, cross-linked PVP, and steviol glycosides, add t...

Embodiment 3

[0049] The preparation of the ebony gargle effervescent tablet that promotes saliva secretion of embodiment 3

[0050] 1) Effervescent tablets for saliva secretion-promoting ebony mouthwash, made of the following raw materials in parts by weight: 18 parts by weight of citric acid, 4.5 parts by weight of tartaric acid, 18 parts by weight of sodium carbonate, 2.5 parts by weight of polyvinylpyrrolidone, 4.5 parts by weight of polyethylene glycol Diol 6000, 1 part by weight of steviol glycoside, 0.2 part by weight of cross-linked PVP, 0.3 part by weight of peppermint oil, 20 parts by weight of mannitol, 0.05 part by weight of potassium sorbate, 26 parts by weight of black plum extract, and 6 parts by weight of gallnut extract.

[0051] 2) Grind the above-mentioned raw materials through a 140-mesh sieve, weigh them according to the stated parts by weight, and set aside.

[0052] 3) Uniformly mix citric acid, tartaric acid, ebony extract, cross-linked PVP, and steviol glycosides, a...

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Abstract

The invention provides a fructus mume mouth wash effervescent tablet with a function of accelerating salivary secretion, and a preparation method thereof. The mouth wash effervescent tablet provided by the invention solves the problems that medicines for clinically alleviating xerostomia are few, a side effect is great, a traditional bottled mouth wash is small in volume and inconvenient in carrying and the antibacterial ingredients of the Western medicines of the mouth wash have poor effects and the like. The mouth wash effervescent tablet adopts a wet process preforming technology and is prepared from fructus mume extracts, galla chinensis extracts, acidulants, alkaline agents, fillers, corrigents and other fructus mume effervescent tablet basic auxiliary materials. The fructus mume extract ingredients in the mouth wash effervescent tablet disclosed by the invention have an obvious function of accelerating the salivary secretion, and a mixed formula of galla chinensis extracts and fructus mume extracts has an excellent inhibition function on various decayed tooth pathogenic bacteria. The mouth wash effervescent tablet disclosed by the invention is convenient in carrying, and is very suitable for the oral cavity healthcare of crowds, including xerostomia patients, people who have a high oral cavity cleaning requirement, business travellers and the like.

Description

technical field [0001] The invention relates to a ebony mouthwash effervescent tablet with the effect of promoting saliva secretion and a preparation method thereof. The invention belongs to the technical field of medicine. Background technique [0002] Epidemiological studies have shown that the incidence of xerostomia in the population is as high as 10%-30%, and there are about 200 million patients in my country. Xerostomia is a multifactorial disease of unknown etiology, and approximately 70% of patients complaining of dry mouth have a systemic etiology. Xerostomia causes chapped lips and a burning sensation in the mucous membranes, affecting functions such as swallowing, speech, chewing, and appetite. At the same time, the reduction of saliva secretion reduces the mucosal resistance, leading to the imbalance of oral flora, secondary Candida albicans infection, rampant dental caries, severe periodontitis and other serious complications, which affect the quality of life ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/98A61K8/9789A61K8/86A61K8/02A61Q11/00A61Q17/00A61P1/02A61P31/02A61P31/04
CPCA61K8/0216A61K8/86A61K8/987A61K2800/592A61Q11/00A61Q17/005A61K8/9789A61P1/02A61P31/02A61P31/04
Inventor 吕高远牛玉梅赵祎镭刘杰孙靖宣董安迪
Owner HARBIN MEDICAL UNIVERSITY
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