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Drug-loaded nanofiber as well as preparation method and application thereof

A drug-loaded nanofiber and nanofiber technology, which is applied in pharmaceutical formulations, fiber processing, and fiber chemical characteristics, can solve problems such as drug-loaded nanofibers that have not yet been found, and drug-loaded nanofibers cannot be used for scar treatment. The effect of shortening wound healing time and preventing wound infection

Active Publication Date: 2019-11-22
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, neither of the drug-loaded nanofibers prepared in these two patent applications can effectively treat scars.
However, no special research has been found on drug-loaded nanofibers that use palmatine as an active component to improve the effect of inhibiting scars.

Method used

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  • Drug-loaded nanofiber as well as preparation method and application thereof
  • Drug-loaded nanofiber as well as preparation method and application thereof
  • Drug-loaded nanofiber as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0035] According to a specific embodiment of the present invention, the drug-loaded nanofiber of the present invention is a product obtained by (blending) electrospinning, that is, all components are mixed and prepared to obtain a mixed spinning solution and then obtained by electrospinning A collection of drug-loaded nanofibers with a nanofibrous structure (drug-loaded nanofiber dressing).

[0036] In a second aspect, the present invention provides a method for preparing drug-loaded nanofibers, the preparation method comprising: electrospinning a spinning solution containing palmatine and auxiliary components to obtain drug-loaded nanofibers.

[0037] In the present invention, the electrospinning is a blended electrospinning method, and the conditions of the blended electrospinning method are not particularly limited, and can be conventionally selected in the field. Preferably, the conditions of electrospinning make the monofilament diameter of drug-loaded nanofibers 80-500nm...

Embodiment 1

[0076] Polycaprolactone was dissolved in a mixed solvent of acetic acid / anhydrous formic acid (volume ratio 3:1) to prepare a solution with a concentration of 20% by weight. The gelatin was dissolved in a mixed solvent of acetic acid / anhydrous formic acid (volume ratio 3:1) to prepare a solution with a concentration of 8% by weight. The polycaprolactone solution and the gelatin solution were mixed according to a mass ratio of 9:1 to obtain a mixed solution, magnetically stirred for 2h, and 2% by weight of palmatine was added (that is, with respect to the polycaprolactone and gelatin solute of 100g, 2g of palmatine was added rattan), magnetically stirred for 1 h to obtain a polycaprolactone / gelatin / palatin spinning solution, which was a homogeneous mixed solution. The resulting spinning solution was ultrasonically degassed (at 35° C. for 10 minutes, the same below), and then electrospun, and the drug-loaded nanofiber membrane was collected on aluminum foil for 24 hours. The sp...

Embodiment 2

[0082] Polycaprolactone was dissolved in a mixed solvent of acetic acid / anhydrous formic acid (volume ratio 2:1) to prepare a solution with a concentration of 22% by weight. The gelatin was dissolved in a mixed solvent of acetic acid / anhydrous formic acid (volume ratio 4:1) to prepare a solution with a concentration of 7% by weight. Polycaprolactone solution and gelatin solution were mixed according to the mass ratio of 6:1 to obtain a mixed solution, magnetically stirred for 2h, and 5% by weight of palmatine was added (that is, with respect to the polycaprolactone and gelatin solute of 100g, 5g of palmatine was added rattan), magnetically stirred for 1 h to obtain a polycaprolactone / gelatin / palatin spinning solution, which was a homogeneous mixed solution. After the obtained spinning solution was ultrasonically degassed, electrospinning was performed, and the drug-loaded nanofiber membrane was collected on aluminum foil for 24 hours. The spinning conditions are as follows: p...

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Abstract

The invention relates to topical skin products and in particular to a drug-loaded nanofiber as well as a preparation method and application thereof. The drug-loaded nanofiber contains nanofibers formed by auxiliary components and palmatine loaded on the nanofibers, wherein the content of the auxiliary components is 5-75g relative to the palmatine per gram. The preparation method of the drug-loadednanofiber comprises the following steps: performing electrostatic spinning on a spinning solution containing the palmatine and auxiliary components so as to obtain the drug-loaded nanofiber. The invention furthermore relates to application of the drug-loaded nanofiber in preparation of a topical skin product for inhibiting scars. The drug-loaded nanofiber takes the palmatine as an active ingredient, the drug action of the active ingredient is released in a sustained manner, and the drug-loaded nanofiber has effects of promoting healing, diminishing inflammation, regulating growth and proliferation behaviors of cells and further effectively inhibiting formation and growth of the scars, can be widely applied to the topical skin products, and is particularly used for dressings. The drug-loaded nanofiber disclosed by the invention is prepared by adopting a blend electrostatic spinning method, the preparation process is simple, and the prepared drug-loaded nanofiber is continuous and uniform.

Description

technical field [0001] The present invention relates to external skin products, in particular to drug-loaded nanofibers and their preparation methods and applications. Background technique [0002] Every year, 80 million people around the world are affected by skin scars, including traffic accidents, fires, and skin trauma caused by military operations. The formation of scars increases social and medical costs, and brings economic loss and mental burden to patients, and affects the quality of life after recovery. Scars mainly form and develop within four weeks after skin trauma, and are mainly reconstructed and repaired within six months thereafter. At present, the main treatment plan for scars is to perform drug or physical interference and treatment during the scar formation period after the wound has healed, which is ineffective and prone to recurrence. [0003] Polycaprolactone is a semi-crystalline polymer, which is an aliphatic polyester obtained by ring-opening with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/46A61L15/20A61L15/32A61L15/26A61L15/62A61L15/42D01F8/14D01F8/02D01F1/10D01D5/00
CPCA61L15/20A61L15/26A61L15/32A61L15/42A61L15/46A61L15/62A61L2300/216A61L2300/404A61L2300/412A61L2400/12D01D5/0015D01F1/103D01F8/02D01F8/14C08L89/00C08L67/04
Inventor 陈旭蒋志敏李迎迎韦日明黄德青梁能堂谢秋花陈智梅卢燕兰
Owner GUILIN MEDICAL UNIVERSITY
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