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Injectable temperature-sensitive compound antibacterial hydrogel material containing tannin and preparing method and application of compound antibacterial hydrogel material

A compound antibacterial and hydrogel technology, applied in the field of biomedical materials and its preparation, to achieve the effects of promoting skin regeneration, good biodegradability, and reducing toxicity

Active Publication Date: 2019-11-15
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve various problems existing in existing wound dressings, the object of the present invention is to provide an injectable temperature-sensitive composite antibacterial hydrogel material containing tannic acid and its preparation and application

Method used

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  • Injectable temperature-sensitive compound antibacterial hydrogel material containing tannin and preparing method and application of compound antibacterial hydrogel material
  • Injectable temperature-sensitive compound antibacterial hydrogel material containing tannin and preparing method and application of compound antibacterial hydrogel material
  • Injectable temperature-sensitive compound antibacterial hydrogel material containing tannin and preparing method and application of compound antibacterial hydrogel material

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Experimental program
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Embodiment 1

[0036] The preparation of embodiment 1 thermosensitive chitin derivative A

[0037] According to our previous research work [Chinese invention patent application publication specification CN201410170871.8], hydroxypropyl chitin with low degree of deacetylation was prepared in a sodium hydroxide-urea system by a homogeneous method. Weigh 2 grams of purified chitin, stir and disperse it in 100 grams of pre-frozen aqueous solution containing 11wt% sodium hydroxide and 4wt% urea, freeze at -30°C for 24 hours, take it out and mechanically stir it at room temperature to thaw it to dissolve chitin aqueous solution. 11.4 g of propylene oxide was added to the obtained chitin solution (100 g, 2 wt %), the system was stirred at 2°C to mix the reactants uniformly, then the temperature was raised to 5°C for 24 hours, and then the temperature was raised to 15°C for 6 hours. Finally, the system was cooled to 2°C, the pH value of the system was adjusted to 7 with 3M hydrochloric acid, dialyz...

Embodiment 2

[0039] The preparation of embodiment 2 hydroxypropyl chitin / tannic acid / ferric chloride HPCH / TA / Fe hydrogel

[0040] The thermosensitive hydroxypropyl chitin HPCH, tannic acid TA and ferric chloride hexahydrate FeCl prepared in embodiment 1 3 ·6H 2 O is dissolved in ultrapure water at a low temperature of 2-14°C, and a HPCH solution with a mass concentration of 3wt%, a TA solution of 0.75wt% and a FeCl of 0.8wt% are prepared 3 ·6H 2 O solution. Take 1g of HPCH solution and add 0.4g of TA solution at a low temperature of 2-14°C and quickly vortex to mix evenly, then quickly add 0.1g of FeCl 3 Vortex and mix the solution at a low temperature of 2-14°C, and adjust the pH to 7.4 with 1M NaOH solution. The neutral solution containing tannic acid has good fluidity at a low temperature of 2-14°C, and can be injected or sprayed. Stand in a water bath at 37°C for 1 min to form a hydrogel ( figure 1 ).

Embodiment 3

[0041] Embodiment 3: the preparation of hydroxypropyl chitin / tannic acid / ferric chloride HPCH / TA / Fe hydrogel

[0042] The thermosensitive hydroxypropyl chitin HPCH, tannic acid TA and ferric chloride hexahydrate FeCl prepared in embodiment 1 3 ·6H 2 O was dissolved in ultrapure water at a low temperature of 4°C, and the HPCH solution with a mass concentration of 3wt%, 0.75wt% TA solution and 9.6wt% FeCl were prepared 3 ·6H 2 O solution. Take 1g of HPCH solution and add 0.4g of TA solution at a low temperature of 2-15°C and quickly vortex to mix evenly, then quickly add 0.1g of FeCl 3 The solution was vortexed and mixed evenly at a low temperature of 2-10°C. Use 1M NaOH solution to adjust the pH to 7.4. The neutral solution containing tannic acid has good fluidity at a low temperature of 2-10°C, and it can be injected or sprayed. Put it in a water bath with a temperature of 37°C for 1 min. Quickly forms a hydrogel. Similar results were obtained by using the HPCH solution ...

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Abstract

The invention provides an injectable temperature-sensitive compound antibacterial hydrogel material containing tannin and a preparing method and application of the compound antibacterial hydrogel material. The material has temperature sensitivity and pH sensitivity, can be injected in situ or sprayed, and can be used as an antibacterial dressing. Firstly, a temperature-sensitive polyhydroxyl-containing polymer such as a chitin derivative is dissolved in water at low temperature, a tannin solution and a metal ion solution are added in a liquid state for uniform mixing, then the compound antibacterial hydrogel material is injected or sprayed on the surface of a wound, and gel can be quickly formed at the body temperature, wherein the tannin is regarded as a cross-linking agent, and also chelated with metal ions to serve an antibacterial agent capable of being slowly released. The antibacterial hydrogel dressing mainly has the advantages that the preparation is simple, the low-temperaturefluidity is good, the gel is quickly formed at the body temperature, the antibacterial agent can be slowly released, the antibacterial range is wide, and the antibacterial time is long; the compoundantibacterial hydrogel material has good biocompatibility and biodegradability, and secondary injuries triggered during dressing changing are avoided; wound healing is facilitated, skin regeneration is effectively promoted, the formation of scars is reduced, and the injectable temperature-sensitive compound antibacterial hydrogel material also has the anti-inflammatory and anti-oxidation effects.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials and their preparation, and relates to an injectable temperature-sensitive composite antibacterial hydrogel material containing tannic acid and its preparation and application. Background technique [0002] The skin is composed of stratum corneum, epidermis and dermis, and is the basic barrier to protect internal tissues, prevent pathogens from invading, and maintain body fluid balance. However, wounds such as cuts, contusions, cuts, and burns can impair the function of the skin, causing bacterial infections, excessive loss of protein and water, endocrine and immune system disorders, and other problems. Traditional medical dressings such as gauze, bandages, and cotton wool are made of dry fabrics, which can absorb the tissue exuded in the early stage, but they cannot provide a moist environment for the wound, and are easy to adhere to the wound, and it is easy to damage the newly forme...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0066A61L26/008A61L26/009A61L26/0095A61L2300/232A61L2300/404A61L2300/41A61L2300/412A61L2300/604A61L2400/06
Inventor 蒋序林马梦思钟亚兰
Owner WUHAN UNIV
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