Cancer biomolecule marker screening method and system based on network topology parameters

Abstract

The invention discloses a cancer biomolecule marker screening method and system based on network topology parameters. The method comprises the steps that a human gene interaction network and gene chipexpression data are acquired and integrated to obtain a gene interaction network based on gene expression data; a disease state and control state gene interaction network is constructed; network topology parameter difference genes of the disease state and control state gene interaction network are calculated, and a network topology parameter difference change network is obtained based on the network parameter difference genes; network module mining is performed on the network topology parameter difference network; feature selection is performed on an obtained difference network module to obtain genes capable of distinguishing normality and diseases in all modules; the classification effect of the genes selected from the modules on the diseases is detected, and the difference network module is screened according to the classification effect to serve as a biomolecule marker candidate. The invention provides a novel complex disease biomarker identification method based on omics data, andexperiments prove that the method has certain accuracy and effectiveness.

Description

Technical field [0001] The invention belongs to the technical field of biological information extraction, and in particular relates to a cancer biomolecular marker screening method and system based on network topology parameters. Background technique [0002] The statements in this section merely provide background information related to the present disclosure, and do not necessarily constitute prior art. [0003] Cancer (malignant tumor) is a large class of diseases that threaten human life and health. At present, the incidence and mortality rates are increasing year by year in the world. According to statistics, in 2018, 18.1 million new cancer cases and 9.6 million cancer deaths are expected to occur. Among them, China is expected to have over 4.05 million new cancer cases and over 2.61 million cancer deaths, and an average of 10,000 are diagnosed with cancer every day. , The situation is very grim. [0004] Liver cancer, or liver malignant tumor, is the sixth most common diagno...

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Problems solved by technology

The above-mentioned biomarkers that have been discovered all have the disadvantages of low HCC specificity and low precision, so it is urgent to find new and effective biomarkers to assist relevant clinical tests and diagnoses

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