Preparation method of medical foam dressing with slow-release antibacterial effect

Abstract

The invention relates to a preparation method of a medical foam dressing with a slow-release antibacterial effect, and belongs to the technical filed of dressings. According to the preparation method,silver ions are loaded on chitosan fibers, nano-zinc oxide is loaded on sodium alginate fibers, toluene diisocynate and polyethylene glycol are taken as raw materials, and the medical foam dressing with the slow-release antibacterial effect is prepared through a foaming technology; the sodium alginate fibers have the moisture absorbing performance and thus are very suitable for the medical dressing; alginic acid is a polysaccharide substance extracted from marine plants and is a random linear segmented copolymer formed by guluronic acid (G) and mannuronic acid (M) which are subjected to bonding through glucosidic bonds; chitosan is also a natural macromolecular compound and has the good biocompatibility and antibacterial property; and after blending, the silver ions and the nano-zinc oxide can be embedded in a three-dimensional mesh molecular structure of the sodium alginate fibers, thus the problems of discoloration, falling-off, burst release, high cytotoxicity and the like of the silver ions are expected to be relieved, and thus the slow-release antibacterial effect is achieved.

Description

technical field [0001] The invention relates to a preparation method of a medical foam dressing with slow-release antibacterial properties, belonging to the technical field of dressings. Background technique [0002] As a temporary substitute for damaged skin, medical dressings can cover the skin wound to protect the wound, avoid secondary damage to the skin, and provide a favorable environment for wound healing. With the rapid development of my country's economy and pharmaceutical industry, people put forward higher requirements for extracorporeal hemostatic medical dressing materials. Dressings for external wounds not only require their functions and mechanical properties to meet the purpose of use, but also require users to have good compliance, that is, they will not increase the pain of the patient and cause secondary damage to the affected area during use. Although traditional wound dressings, such as gauze and cotton, can also achieve the purpose of protecting the wo...

AI Technical Summary

Problems solved by technology

[0002] As a temporary substitute for damaged skin, medical dressings can cover the skin wound to protect the wound, avoid secondary damage to the skin, and provide a favorable environment for wound healing. With the rapid development of my country's economy and pharmaceutical industry, people put forward higher requirements for extracorporeal hemostatic medical dressing materials. Dressings for external wounds not only require their functions and mechanical properties to meet the purpose of use, but also require users to have good compliance, that is, they will not increase the pain of the patient and cause secondary damage to the affected area during use. Although traditional wound dressings, such as gauze and cotton, can also achieve the purpose of protecting the wound and hemostasis, they have many disadvantages: for example, they are easy to breed bacteria, and the wound exudate easily forms scabs with dry dermal tissue, hindering epithelialization; It is easy to adhere to the dressing and cause pain when the dressing is lifted, causing secondary trauma

The current antibacterial dressings are mainly silver-based antibacterial dressings. Most of these dressings have problems such as easy oxidation, discoloration, shedding, violent release, and high cytotoxicity of silver ions. In particular, it is difficult to balance the antibacterial effect and cytotoxicity.

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