Injected amino acid derivative micromolecule gel material and application thereof

A small-molecule gel and amino acid technology, which is applied in the field of biomedical engineering in material chemistry, can solve problems such as difficult degradation and complex preparation process, and achieve the effects of convenient operation, good biocompatibility, and excellent slow-release effect

Active Publication Date: 2019-11-08
GANNAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the deficiencies in the existing technology, in order to enrich the types of functionalized small molecule gel materials, overcome the defects of complex preparation process and difficult degradation of traditional hydrogel, and explore the wider application of amino acid derivative small molecule gel materials Value, the invention provides a kind of injectable amino acid derivative small molecule gel material and its application

Method used

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  • Injected amino acid derivative micromolecule gel material and application thereof
  • Injected amino acid derivative micromolecule gel material and application thereof
  • Injected amino acid derivative micromolecule gel material and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] First, mix 10.00mmol 1,4-naphthalene dicarboxylic acid with 20.00mmol thionyl chloride, add 2-3 drops of DMF dropwise, and reflux at 70°C for 4.0 hours, and distill the solvent under reduced pressure to obtain 1,4-naphthalene Diformyl chloride; secondly, add 0.05mol / L 1,4-naphthalene dicarboxylic dichloride solution in dichloromethane drop by drop under ice-bath stirring to contain 0.10mol / L L-phenylalanine methyl ester and 0.13mol / L In the dichloromethane mixture of triethylamine, when the temperature rises to room temperature, continue to stir for 24.0 hours, after 35°C rotary evaporation, dichloromethane dissolution, deionized water extraction, filtration, and 35°C rotary evaporation twice, NDC is obtained. -L-PhOMe; then, prepare a methanol solution of 0.20mol / LNDC-L-PhOMe, add NaOH solution thereto (keep the concentration of NaOH in the methanol-water mixed system at 0.66mol / L), stir at room temperature for 24.0 hours, and then Acidification with HCl solution to a ...

Embodiment 2

[0038] First, mix 20.00mmol 1,4-naphthalene dicarboxylic acid with 40.00mmol thionyl chloride, add 2-3 drops of DMF dropwise, and reflux at 65°C for 5.0 hours, and distill the solvent under reduced pressure to obtain 1,4-naphthalene Diformyl chloride; secondly, add 0.08mol / L 1,4-naphthalene dichloromethane solution dropwise under stirring in an ice bath to contain 0.16mol / L D-phenylalanine methyl ester and 0.16mol / L In the dichloromethane mixture of triethylamine, when the temperature rises to room temperature, continue to stir for 15.0 hours, after 40°C rotary steaming, dichloromethane dissolution, deionized water extraction, filtration, and 40°C rotary steaming twice, NDC is obtained -D-PhOMe; then, prepare a methanol solution of 0.50mol / LNDC-D-PhOMe, add NaOH solution thereto (keep the concentration of NaOH in the methanol-water mixed system at 0.80mol / L), stir at room temperature for 15.0 hours, and then with H 3 PO 4 The solution was acidified to a pH value of 3, and th...

Embodiment 3

[0042] First, mix 30.00mmol 1,4-naphthalene dicarboxylic acid with 60.00mmol thionyl chloride, add 2-3 drops of DMF dropwise, and reflux at 75°C for 5.5 hours, and distill the solvent under reduced pressure to obtain 1,4-naphthalene Diformyl chloride; secondly, add 0.06mol / L 1,4-naphthalene dicarboxylic dichloride solution in dichloromethane drop by drop under ice-bath stirring until containing 0.14mol / L L-phenylalanine methyl ester and 0.20mol / L In the dichloromethane mixture of triethylamine, when the temperature rises to room temperature, continue to stir for 10.0 hours, after 30°C rotary evaporation, dissolving in dichloromethane, deionized water extraction, filtration, and 30°C rotary evaporation twice, to obtain NDC -L-PhOMe; then, prepare a methanol solution of 0.25mol / LNDC-L-PhOMe, add NaOH solution thereto (keep the concentration of NaOH in the methanol-water mixed system at 0.70mol / L), stir at room temperature for 10.0 hours, and then with H 2 SO 4 The solution was...

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Abstract

The invention provides an injected amino acid derivative micromolecule gel material and application thereof, and belongs to the field of biomedical engineering in material chemistry. A preparation method comprises the following steps that first, phenylalanie methyl ester (D/L type) is regarded as a reaction zymolyte, and is modified by 1,4-naphthalic acid (NDC) and diethylene glycol, and amino acid derivative micromolecule gelator NDC-L or / and D-PhOMe, NDC-L or / and D-PhOH; and then, the gelator is added into polyethylene glycol, and heated to be completely dissolved, then equivoluminal deionized water is added, and after mixing, the injected amino acid derivative micromolecule gel material is obtained for several-minute standing. According to the injected amino acid derivative micromolecule gel material and the application thereof, a procedure is relatively simple, operation is convenient, the prepared gel material after freezing and drying is of a three-dimension (or nostoc commune) structure, biocompatibility is good, degradation is easy, the slow-release effect of medicine vitamin B12 is excellent, the gel material can be regarded as a medicine support or vector used for clinic treatment, and great practical prospects are achieved.

Description

technical field [0001] The invention belongs to the field of biomedical engineering in material chemistry, relates to a biomedical material, and more specifically relates to an injection-type amino acid derivative small molecule gel material and its application. Background technique [0002] Small molecule gels are a new class of solid-like functional materials with viscoelastic properties. It is self-assembled by small organic molecules through non-covalent bond interactions (such as: intermolecular hydrogen bonds, halogen bonds, π-π stacking interactions, and van der Waals forces, etc.), showing an ordered three-dimensional network structure. In these network structures, the solvent is bound and cannot flow freely. With the continuous exploration of the properties of small molecule gels, their optical, magnetic, electrical and catalytic properties have attracted more and more attention. In recent years, due to the rapid development of medical materials and tissue enginee...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/18A61K47/10
CPCA61K9/06A61K9/0024A61K47/183A61K47/10
Inventor 贾新建钟菊萍罗序中廖烈强付鸿宇楼浩翔钟祥钟金莲王科军
Owner GANNAN NORMAL UNIV
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