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Manganese carbonate/polyamino acid composition and preparation method thereof

A technology of polyamino acid and manganese carbonate, which is applied in the field of manganese carbonate/polyamino acid compound and its preparation, can solve the problems of difficulty in conforming to biomedical applications, large size of manganese carbonate, low purity, etc., and achieve drug release monitoring and easy operation , The effect of simple preparation process

Active Publication Date: 2019-11-05
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a manganese carbonate / polyamino acid complex and a preparation method thereof, aiming at solving the problem that the manganese carbonate prepared by the existing method has a large size or low purity, and is difficult to meet biological requirements. Questions about medical applications

Method used

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  • Manganese carbonate/polyamino acid composition and preparation method thereof
  • Manganese carbonate/polyamino acid composition and preparation method thereof
  • Manganese carbonate/polyamino acid composition and preparation method thereof

Examples

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Embodiment 1

[0048] (1) At room temperature, 1.980g MnCl 2 • 4H 2 O is dissolved in 10 mL of deionized water to form MnCl with a concentration of 1 mol / L 2 solution; 1.060g Na 2 CO 3 Dissolve in 100mL deionized water to form Na with a concentration of 0.1mol / L 2 CO 3 solution.

[0049] (2) Take 0.1mL, 1mol / L MnCl 2 The solution was added into 0.9mL Tris-HCl buffer (10mmol / L) and mixed evenly to obtain a manganese precursor solution; 0.1mL, 0.1mol / L Na 2 CO 3 The solution was mixed with 0.8 mL Tris-HCl buffer (10 mmol / L) to form a carbonate precursor solution.

[0050] (3) Take 0.1 mL of an aqueous solution containing 4 mg of polyethylene glycol-polyaspartic acid (the molecular weight of polyethylene glycol is 10,000, and the degree of polymerization of polyaspartic acid is 50) and mix it with the above-mentioned carbonate precursor solution , added to the above-mentioned manganese precursor solution, and stood in a refrigerator at 4°C for 12h.

[0051] (4) Then perform centrifuga...

Embodiment 2

[0053] (1) At room temperature, 1.980g MnCl 2 • 4H 2 O is dissolved in 10 mL of deionized water to form MnCl with a concentration of 1 mol / L 2 solution; 1.060g Na 2 CO 3 Dissolve in 100mL deionized water to form Na with a concentration of 0.1mol / L 2 CO 3 solution.

[0054] (2) Take 0.1mL, 1mol / L MnCl 2 The solution was added into 0.9mL Tris-HCl buffer (10mmol / L) and mixed evenly to obtain a manganese precursor solution; 0.1mL, 0.1mol / L Na 2 CO 3 The solution was mixed with 0.8 mL Tris-HCl buffer (10 mmol / L) to form a carbonate precursor solution.

[0055] (3) Take 0.1 mL of an aqueous solution containing 8 mg of polyethylene glycol-polyaspartic acid (the molecular weight of polyethylene glycol is 10,000, and the degree of polymerization of polyaspartic acid is 50) and mix it with the above-mentioned carbonate precursor solution , added to the above-mentioned manganese precursor solution, and stood in a refrigerator at 4°C for 12h.

[0056] (4) Then perform centrifuga...

Embodiment 3

[0058] (1) At room temperature, 1.980g MnCl 2 • 4H 2 O is dissolved in 10 mL of deionized water to form MnCl with a concentration of 1 mol / L 2 solution; 1.060g Na 2 CO 3 Dissolve in 100mL deionized water to form Na with a concentration of 0.1mol / L 2 CO 3 solution.

[0059] (2) Take 0.1mL, 1mol / L MnCl 2 The solution was added into 0.9mL Tris-HCl buffer (10mmol / L) and mixed evenly to obtain a manganese precursor solution; 0.1mL, 0.1mol / L Na 2 CO 3 The solution was mixed with 0.8 mL Tris-HCl buffer (10 mmol / L) to form a carbonate precursor solution.

[0060] (3) Take 0.1 mL of an aqueous solution containing 4 mg of polyethylene glycol-polyaspartic acid (the molecular weight of polyethylene glycol is 10,000, and the degree of polymerization of polyaspartic acid is 50) and mix it with the above-mentioned carbonate precursor solution , added to the above-mentioned manganese precursor solution, and stood in a 4°C refrigerator for 1h.

[0061] (4) Then perform centrifugation...

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Abstract

The invention discloses a manganese carbonate / polyamino acid composition and a preparation method thereof. The preparation method comprises the following steps: A, mixing a manganese salt or a manganese salt aqueous solution with a Tris-HCl buffer solution so as to obtain a manganese precursor solution, and mixing carbonate or a carbonate aqueous solution with the Tris-HCl buffer solution so as toobtain a carbonate precursor solution; B, mixing polyamino acid or a polyamino acid aqueous solution with the manganese precursor solution, adding the carbonate precursor solution, and leaving the solution to stand to implement a reaction; or mixing the polyamino acid or the polyamino acid aqueous solution with the carbonate aqueous solution, adding the manganese precursor solution, and leaving the solution to stand to implement a reaction; and C, performing solid-liquid separation, washing and drying, so as to obtain the manganese carbonate / polyamino acid composition. The preparation methodof biomimetic mineralization is simple and convenient in operation and needs no complex and expensive equipment, and the prepared composition has good biocompatibility, biodegradability and pH response medicine release properties.

Description

technical field [0001] The invention relates to the technical field of biological material preparation, in particular to a manganese carbonate / polyamino acid compound and a preparation method thereof. Background technique [0002] Manganese ion is an important magnetic resonance imaging contrast agent, and also one of the important trace elements in organisms. Therefore, manganese-containing materials such as manganese oxide and manganese carbonate have broad application prospects in biomedicine. Manganese carbonate has a pH-responsive solubility property, and its hydrolysis products are manganese ions and carbon dioxide gas. Among them, the manganese ions produced by hydrolysis can be used for magnetic resonance imaging, and the carbon dioxide gas produced can be excreted through the normal metabolism of the human body. Monitor treatment effects. [0003] At present, the application of manganese carbonate in biomedicine is relatively rare, the main reason is that the syn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L77/00C08K3/26
CPCC08K3/26C08L77/00
Inventor 黄鹏漆超付连花林静
Owner SHENZHEN UNIV
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