Temperature/pH responsive double-drug-loaded composite nano particle and preparation method and use thereof
A composite nanoparticle and nanoparticle technology, which is applied in the field of temperature/pH responsive double drug-loaded composite nanoparticle and its preparation and application, can solve problems such as unsatisfactory curative effect, decrease in white blood cell count, and hinder the proliferation of cancer cells. significant effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0104] Example 1 Preparation method of temperature- and pH-responsive dual-loaded mesoporous silica nanoparticles drug carrier LEBM (1:1)
[0105] 1. Preparation of mesoporous silica nanoparticles (MSNs)
[0106] Add 0.2 g of cetyltrimethylammonium bromide (CTAB) and 10 mL of distilled water to a round-bottomed flask, stir magnetically for 5 min at 40 °C, then add 90 mL of water and 3 mL of ammonia in sequence, and continue magnetically stirring at 40 °C for 2 h , 500 rev / min. Then, 0.5 mL of methyl orthosilicate (TEOS) and 5 mL of ethyl acetate (EA) were added quickly, and after reacting for 6 h, it was cooled to room temperature, and washed three times with water and ethanol successively to obtain a mixture. Weigh 0.5g of ammonium nitrate and dissolve it in 50mL of ethanol, add the above mixture, and reflux at 80°C for 45min. Washed three times with ethanol and water successively to obtain 55.88 mg of mesoporous silica nanoparticles (MSNs), which were dried and stored in v...
Embodiment 2
[0118] The preparation of the double drug-loaded composite nanoparticle of embodiment 2 different proportions
[0119] According to the drug loading of EVO and BBR, by regulating the loading of EVO and BBR, the ratio of EVO and BBR is 6:1 dual response type composite nanoparticles synthesized by the drug loading method described in Example 1. That is, the double-loaded nanoparticles of EVO:BBR (6:1) are LEBM (6:1).
Embodiment 3
[0120] Embodiment 3 Preparation of double drug-loaded composite nanoparticles in different proportions
[0121] According to the drug loading of EVO and BBR, by adjusting the loading of EVO and BBR, the ratio of EVO and BBR is 1:6 dual response type composite nanoparticles synthesized by the drug loading method described in Example 1. That is, the double drug-loaded nanoparticles of EVO:BBR(1:6) are LEBM(1:6).
PUM
Property | Measurement | Unit |
---|---|---|
diameter | aaaaa | aaaaa |
pore size | aaaaa | aaaaa |
encapsulation rate | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com