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Elaeagnus angustifolia polysaccharide extract capable of relieving dry skin inflammation and preparation method thereof

A technology for polysaccharide extraction and skin inflammation, applied in the field of polysaccharide polysaccharide extract and preparation for relieving dry skin inflammation, can solve the problems of waste, economic value not paid attention to, low utilization and the like

Pending Publication Date: 2019-10-22
佛山市康伲爱伦生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, the economic value of the sandy date tree has not attracted much attention. Only a small part of the sandy date has been processed and utilized among the people, and most of them have not been collected, and the utilization is very low, which has caused a lot of waste. The average polysaccharide content is between 9% and 10.9%, and the total polysaccharide content is relatively high. The sugar part mainly contains rhamnose, arabinose, xylose, glucose, mannose, and galactose. The activity has the functions of anti-virus, enhancing immune function, anti-aging, and scavenging free radicals. Through further research, it is found that the polysaccharides of Rhizoma jujube have a good effect on alleviating dry skin inflammation, so the polysaccharides of Rhizoma jujube have broad application prospects in the field of cosmetics
[0006] At present, there is no report that the polysaccharide extract of Eleuthero jujube can inhibit the level of skin inflammatory factors and increase the expression of proteins related to moisturizing factors

Method used

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  • Elaeagnus angustifolia polysaccharide extract capable of relieving dry skin inflammation and preparation method thereof
  • Elaeagnus angustifolia polysaccharide extract capable of relieving dry skin inflammation and preparation method thereof
  • Elaeagnus angustifolia polysaccharide extract capable of relieving dry skin inflammation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Implementation Example 1 Preparation of Polysaccharide Extract from Elaeagnus sativa and Determination of Polysaccharide Content

[0012] application test

[0013] 1. Determining the extraction process test of the polysaccharide

[0014] 1.1 Preparation of polysaccharide extract from Elaeagnus sativa

[0015] (1) Extract the gum of Elaeagnus sativa with a weak acid aqueous solution, specifically, a gum solution dissolved in distilled water with a concentration of 5%, heat it to a temperature of 80°C, and add hydrochloric acid with a concentration of 8% while stirring, and use a concentration of 10 % hydrogen peroxide for 2 minutes to decolorize to obtain a polysaccharide solution (2) add 3-6 times the volume of acetone to the polysaccharide solution for precipitation, and centrifuge to obtain the polysaccharide sediment (3) freeze-dry the polysaccharide sediment, filter, Pulverize the obtained Elaeagnus polysaccharide white powder.

[0016] 1.2 Determination of the s...

Embodiment 2

[0022] Implementation Example 2 Experiment of the Effect of Elaeoptera Polysaccharide Extract on Hacat Cell Inflammation Model Induced by LPS (The Polysaccharide Content of Elaeoptera Polysaccharide Extract is 0.05%-95%)

[0023] application test

[0024] 2. Determination of cytotoxicity of polysaccharide extract from Eleuthero jujube

[0025] 2.1 Configuration of Elaeagnus polysaccharide extract solution

[0026] Prepare the extract mother solution of Eleuthero jujube polysaccharide (EPA) with a concentration of 10mg / ml (dissolved in distilled water). Use the mother liquor to prepare 2ml of extract storage solutions (diluted with distilled water) with concentrations of 10mg / ml, 5mg / ml, 2.5mg / ml, 1.25mg / ml, and 0.625mg / ml, respectively, and store them for later use. The solutions to be tested with concentrations of 500 μg / ml, 250 μg / ml, 125 μg / ml, 62.5 μg / ml, and 31.25 μg / ml were prepared by using stock solution of Elaeoptera polysaccharide (EPA) at various concentrations a...

Embodiment 3

[0033] Implementation Example 3 Experiment of the effect of the polysaccharide extract of Eleuthero jujuba on the acetone / ether skin dryness model of mice (the polysaccharide content of the polysaccharide extract of Artemisia saponica is 0.05%-95%)

[0034] application testing

[0035] 3. Experiment on the effect of polysaccharide extract from Eleuthero jujube on mouse skin acetone / ether skin dryness model

[0036] 3.1 Mice modeling and administration methods

[0037]6 rats in the model (injury) group; 6*3 rats in the injury administration group; the blank control group and the positive control group are shared with 1). There are 24 in total. 2 days before modeling, shave and depilate with 1% NaS. On the day of modeling, dry the model with acetone / ether-water (AEW): dip a 2cm×2cm absorbent cotton with a mixture of acetone:ether=1:1 and cover the depilated area for 15s , and then take another 2cm×2cm absorbent cotton dipped in distilled water and cover it on the depilated ar...

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Abstract

The invention relates to an Elaeagnus angustifolia polysaccharide extract capable of relieving dry skin inflammation and a preparation method thereof. The Elaeagnus angustifolia polysaccharide of theinvention is prepared from Elaeagnus angustifolia gum through a water extraction and alcohol precipitation process. Researches show that the extract containing Elaeagnus angustifolia polysaccharide has the effect of relieving dry skin inflammation. The Elaeagnus angustifolia polysaccharide extract can be made into various dosage forms such as gel, a liquid, an emulsion, an ointment, solid particles, etc., and is applied to the fields of cosmetic and dermatosis accessory therapeutic medicines and the like.

Description

technical field [0001] The present invention relates to a polysaccharide extract of Elaeagnus japonicus with anti-inflammatory and moisturizing effects. The extract can effectively promote the expression of moisturizing factors Filaggrin FLG and loricrin LOR while inhibiting the skin inflammatory factor IL-6 And the expression of TNFα, it can be added to cosmetics as functional active substances for skin care. Background technique [0002] Skin covers the surface of the whole body and is one of the largest organs of the human body. It is the tissue directly in contact with the external environment and is the body's natural skin barrier, skin barrier and physical barrier. Composed of polysaccharides, etc., it resists external harmful substances, irritants, and sunlight, and at the same time has moisturizing and regulating anti-inflammatory effects. [0003] The natural moisturizing system in human skin is mainly composed of water, lipids, natural moisturizing factor (Natural...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K31/715A61P17/00A61P29/00
CPCA61K36/185A61K31/715A61P17/00A61P29/00A61K2236/331A61K2236/53A61K2236/51
Inventor 杜志云王炳英韩萍林丽李志威马诗经朱林静莫其标
Owner 佛山市康伲爱伦生物技术有限公司
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