Sodium bicarbonate Ringer injection and preparation method thereof
A technology of Ringer's injection and sodium bicarbonate, which is applied in the field of medicine and can solve problems such as increased safety risks, Ringer's solution precipitation, and affecting the quality of preparations
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Embodiment 1
[0030] Sodium Bicarbonate Ringer's Injection was prepared using the following steps:
[0031] 1. Add 65L of water for injection into the preparation tank, add citric acid, sodium chloride, potassium chloride, calcium chloride dihydrate, and magnesium chloride hexahydrate in turn according to the prescription amount and stir to dissolve;
[0032] 2. Adjust the temperature of the solution in the preparation tank in step 1 to 38°C, add the prescribed amount of L-malic acid and stir to dissolve, then add the prescribed amount of sodium bicarbonate and stir to dissolve, add water for injection to 100L;
[0033] 3. Measure the pH value and content of the preparation tank solution in step 2, filter it with a 0.22 μm filter membrane, fill it according to the 500ml specification, and sterilize it at 121° C. for 15 minutes after filling to obtain Sodium Bicarbonate Ringer Injection.
[0034] Wherein: the specific prescription of described sodium bicarbonate Ringer's injection is:
[00...
Embodiment 2
[0050] Sodium Bicarbonate Ringer's Injection was prepared using the following steps:
[0051] 1. Add 65L of water for injection into the preparation tank, add citric acid, sodium chloride, potassium chloride, calcium chloride dihydrate, and magnesium chloride hexahydrate in turn according to the prescription amount and stir to dissolve;
[0052] 2. Adjust the temperature of the solution in the preparation tank in step 1 to 38°C, add the prescribed amount of L-malic acid and stir to dissolve, then add the prescribed amount of sodium bicarbonate and stir to dissolve, add water for injection to 100L;
[0053] 3. Measure the pH value and content of the solution in the preparation tank in step 2, filter it with a 0.22 μm membrane, fill it into 200 bottles according to the 500ml specification, and sterilize it at 121° C. for 15 minutes after filling to obtain Sodium Bicarbonate Ringer Injection.
[0054] Wherein: the specific prescription of described sodium bicarbonate Ringer's inj...
Embodiment 3~4
[0063] The preparation method is the same as that of Example 2, except that in step 2, the temperature of the solution in the preparation tank is adjusted to 39°C and 40°C respectively.
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