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A drug-loaded polyvinyl alcohol microsphere

A polyvinyl alcohol microsphere and drug-loaded technology, which is applied in the field of medicine, can solve the problems of small maximum drug absorption and slow drug release, and achieve the effects of fast drug release, small particle size distribution, and excellent effects

Active Publication Date: 2020-08-07
赵修文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to solve the problems of small maximum drug absorption and slow drug release rate of similar drugs in the past, and specifically provides a polyvinyl alcohol microsphere and a preparation method thereof. The polyvinyl alcohol microsphere has a good shape and a uniform particle size

Method used

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  • A drug-loaded polyvinyl alcohol microsphere
  • A drug-loaded polyvinyl alcohol microsphere
  • A drug-loaded polyvinyl alcohol microsphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Dissolve aminoacetaldehyde dimethyl acetal in dichloromethane in a pear-shaped flask; stir, slowly add acryloyl chloride to the liquid phase at 0°C, the reaction is exothermic; slowly add triethylamine dropwise, and let the system Rise to room temperature and react for another 3 hours; after the reaction is completed, wash with water and dichloromethane, suspend to dry and suction filter, and seal and store at room temperature.

[0040] Accurately weigh a certain amount of polyvinyl alcohol particles, swell in deionized water for a period of time, place them in a water bath and heat up to 90°C with the water bath, stir to dissolve them completely, and obtain transparent polyethylene with a certain viscosity Alcohol solution, the mass fraction is 10%. Under the action of magnetic stirring, add N-acryloyl-aminoacetaldehyde-dimethyl acetal into the polyvinyl alcohol solution, then adjust the pH value of the system to 1-2 with hydrochloric acid, and react at 40°C for 24 hou...

Embodiment 2

[0043] The cross-linking reaction temperature of the polyvinyl alcohol solution in Example 1 was replaced from 55°C to 25°C, and the other reaction conditions were the same as in Example 1, and the microsphere product M2 was obtained by using this method. The test results showed that the dispersion of microspheres M2 prepared at 25°C was poor, and the adhesion between microspheres was very serious.

Embodiment 3

[0045] The cross-linking reaction temperature of the polyvinyl alcohol solution in Example 1 was replaced from 55°C to 80°C, and the other reaction conditions were the same as in Example 1, and the microsphere product M3 was obtained by using this method. The test results show that the microspheres M3 prepared at 80°C have good dispersion, but the spherical shape is irregular, the particle size is large and the distribution is not uniform.

[0046] From the comparison of Examples 1-3, it can be seen that the crosslinking reaction temperature has a significant impact on the morphology, dispersibility and particle size distribution of the microspheres. The present invention proves through the above tests that only by controlling the crosslinking reaction temperature around 55°C can the polyvinyl alcohol microspheres with better shape, higher dispersibility and uniform particle size distribution be obtained.

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Abstract

The invention relates to a drug-loaded polyvinyl alcohol microsphere and a preparation method thereof. The polyvinyl alcohol microsphere is prepared from a cellulose acetate butyrate solution, a macro-molecular monomer solution, acrylamide-2-methylpro panesulfonic scid sodium salt solution, potassium persulfate and the like. The polyvinyl alcohol microsphere has the characteristics of high drug absorptive amount, high drug release speed, high roundness and good dispersity of microsphere appearance and small and uniform grain size distribution.

Description

technical field [0001] The invention relates to the field of drugs, in particular to a drug-loaded microsphere. Background technique [0002] Transcatheter arterial embolization (TAE) is a technique in which embolic agents are injected through a catheter into the blood vessel to be embolized under the guidance of imaging equipment to achieve the desired therapeutic purpose, also known as embolization therapy. Transcatheter arterial chemoembolization (TACE) is a treatment method that combines chemotherapy and embolization. In traditional TACE, chemotherapeutic drugs are first infused locally and then a blank embolic agent is used for embolization intervention. TACE is the main treatment for advanced liver cancer. It can effectively prolong the survival period of patients and improve the quality of life of patients. It is currently recognized as the first choice for non-surgical treatment of liver cancer. [0003] Microspheres loaded with chemotherapeutic drugs have been a ho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K47/32A61K47/26A61K31/704A61K31/4745A61P35/00A61L31/04A61L31/16
CPCA61K9/1623A61K9/1635A61K9/1676A61K31/4745A61K31/704A61L31/048A61L31/16A61L2300/216A61L2300/23A61L2300/416A61P35/00A61K2300/00C08L29/04
Inventor 赵修文邹英华阴国印
Owner 赵修文
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