A kind of oral osteoinductive regeneration membrane and preparation method thereof

An osteoinductive and regenerative membrane technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of poor therapeutic effect and simple structure, and achieve the effect of increasing the treatment cycle, preventing displacement, and accelerating the reproduction of osteoblasts

Active Publication Date: 2021-11-02
SHANGHAI DIVINE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Aiming at the problems that the current oral osteoinductive regenerative membrane has a simple structure and poor therapeutic effect, the present invention provides an oral osteoinductive regenerative membrane and a preparation method thereof

Method used

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  • A kind of oral osteoinductive regeneration membrane and preparation method thereof
  • A kind of oral osteoinductive regeneration membrane and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] This embodiment provides a kind of oral osteoinductive regenerative membrane, such as figure 1 and figure 2 As shown, it includes hydrophobic layer a1, hydrophobic layer b2 and hydrophilic layer c3 arranged in sequence; the hydrophobic layer a1, hydrophobic layer b2 and hydrophilic layer c3 all have a porous three-dimensional structure; the thickness of the hydrophobic layer a1 is 0.1mm , the thickness of the hydrophobic layer b2 is 0.15 mm, and the thickness of the hydrophilic layer c3 is 0.1 mm.

[0043] The preparation steps of the oral osteoinductive regenerative membrane are as follows:

[0044] A. Dissolve suspending polylactic acid, L-polylactic acid, and acetyl tributyl citrate in dichloromethane in a mass ratio of 7:2:1, configure a polymer solution with a concentration of 10% (m / v), and stir evenly spare;

[0045] B. Pour the polymer solution obtained in step A into a coating machine, and use a solvent evaporation method to obtain a hydrophobic layer a and...

Embodiment 2

[0054] This embodiment provides an oral cavity osteoinductive regeneration membrane, including a hydrophobic layer a, a hydrophobic layer b, and a hydrophilic layer c arranged in sequence; the hydrophobic layer a, the hydrophobic layer b, and the hydrophilic layer c all have a porous three-dimensional structure; The thickness of the hydrophobic layer a is 0.2 mm, the thickness of the hydrophobic layer b is 0.2 mm, and the thickness of the hydrophilic layer c is 0.2 mm.

[0055] The preparation steps of the oral osteoinductive regenerative membrane are as follows:

[0056] A. Dissolve polylactic acid, polylactic acid, and tributyl acetyl citrate in dichloromethane in a mass ratio of 6:1:0.5, and prepare a polymer solution with a concentration of 20% (m / v), and stir evenly spare;

[0057] B. Add the polymer solution obtained in step A to 4-6 times the volume of ethanol to precipitate, stir for 1 h, filter with a Buchner funnel to obtain a solid mixture, and then dry under reduc...

Embodiment 3

[0066] This embodiment provides an oral cavity osteoinductive regeneration membrane, including a hydrophobic layer a, a hydrophobic layer b, and a hydrophilic layer c arranged in sequence; the hydrophobic layer a, the hydrophobic layer b, and the hydrophilic layer c all have a porous three-dimensional structure; The thickness of the hydrophobic layer a is 0.2 mm, the thickness of the hydrophobic layer b is 0.3 mm, and the thickness of the hydrophilic layer c is 0.1 mm.

[0067] The preparation steps of the oral osteoinductive regenerative membrane are as follows:

[0068] A. Dissolve polylactic acid, polylactic acid, and tributyl acetyl citrate in dichloromethane in a mass ratio of 8.5:2.5:1.5, and prepare a polymer solution with a concentration of 15% (m / v), and stir evenly spare;

[0069] B. Add the polymer solution obtained in step A to 4-6 times the volume of ethanol to precipitate, stir for 4 hours, filter with a Buchner funnel to obtain a solid mixture, and then dry und...

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Abstract

The present invention relates to an oral cavity osteoinductive regeneration film and a preparation method thereof. The inductive regeneration film comprises a hydrophobic layer a, a hydrophobic layer b and a hydrophilic layer c arranged in sequence; the hydrophobic layer a, the hydrophobic layer b and the hydrophilic layer c all have a porous three-dimensional structure; the thickness of the hydrophobic layer a is 0.1-0.2mm, the thickness of the hydrophobic layer b is 0.15-0.3mm, and the thickness of the hydrophilic layer c is 0.1-0.2mm. The hydrophobic layer a, the hydrophobic layer b and the hydrophilic layer c are laser welded or ultrasonically welded to form a composite film. The induced regenerative membrane has a special spatial structure, which is conducive to the growth of epithelial tissue, gingival tissue, etc., further fixes the implantation position of the membrane, and prevents the displacement of the membrane.

Description

technical field [0001] The invention relates to the technical field of osteoinductive regeneration membranes, in particular to an oral osteoinductive regeneration membrane and a preparation method thereof. Background technique [0002] With the improvement of oral medical level, the technology of oral implant surgery is becoming more and more mature. Sufficient alveolar bone is the key to the success of the operation. Due to the growth of age, many patients have severe bone loss and cannot provide sufficient strength support for the implant. Therefore, it is necessary to repair the alveolar bone through surgical intervention before implant surgery. [0003] Guided bone regeneration (GBR) technology originated from guided tissue regeneration (GTR), and is recognized as an effective way to increase bone mass. Under normal circumstances, alveolar bone can regenerate or repair like damaged bone self-growth, but gingival tissue regenerates faster than alveolar bone. Therefore, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/56A61L27/50
CPCA61L27/18A61L27/50A61L27/56A61L2430/12C08L67/04C08L71/02
Inventor 郑效东
Owner SHANGHAI DIVINE MEDICAL TECH
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