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Composition for inhibiting myofibrosis

A technology for muscle fibers and compositions is applied in the field of compositions for inhibiting muscle fibrosis, which can solve the problems of unknown differentiation of muscle satellite cells, and achieve the effect of inhibiting muscle fibrosis and high safety.

Inactive Publication Date: 2019-10-08
SUNTORY HLDG LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, the effect of quercetin on the differentiation of muscle satellite cells into myofibroblasts has not been known until now

Method used

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  • Composition for inhibiting myofibrosis
  • Composition for inhibiting myofibrosis
  • Composition for inhibiting myofibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] Induction of muscle satellite cell differentiation into myofibroblasts from rat skeletal muscle

[0101] (1) Isolation and culture conditions of muscle satellite cells

[0102] Under anesthesia, the gastrocnemius, soleus, plantaris, tibialis anterior, extensor digitorum longus, and quadriceps muscles were removed from male Fischer344 rats aged 9 to 15 weeks, and placed in phosphate-buffered saline on ice. (PBS) (Life Technologies Corporation). At 37° C., the minced muscle tissue was enzymatically decomposed by protease (SIGMA Company), and centrifuged repeatedly to separate muscle satellite cells. Muscle satellite cells were suspended in Dulbecco's Modified Eagle Medium (DMEM) containing 10% fetal horse serum, and cultured for 24 hours. Carry out centrifugation again after cultivating, in the F-10 medium (GIBCO company) containing 20% ​​bovine serum, to reach 5 * 10 4 ~7×10 4 Density of cells / mL Pelleted muscle satellite cells were seeded into 8-well chamber slides ...

manufacture example 1

[0115] (Manufacture example 1) tablet

[0116]

[0117] The above-mentioned substances were mixed, and a tablet with a diameter of 9 mm and a mass of 300 mg was produced by tableting with a single-punch tablet press.

manufacture example 2

[0118] (production example 2) healthy drink

[0119]

[0120] Mix the above ingredients and add water to make 1 liter. The healthy drink should be consumed above 100mL each time.

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Abstract

The purpose of the present invention is to provide: a composition for inhibiting myofibrosis, which contains, as an active ingredient, a component that can be safely ingested over a prolonged period of time; and a method for safely inhibiting myofibrosis. The present invention provides a composition for inhibiting myofibrosis, which contains quercetin or a glycoside thereof as an active ingredient.

Description

technical field [0001] The present invention relates to a composition for inhibiting myofibrosis. The present invention also relates to methods for inhibiting muscle fibrosis and the like. Background technique [0002] In Japan, a super-aging society, medical care advances, and the proportion of late-stage elderly people increases, but on the other hand, the extension of healthy life expectancy and the improvement of quality of life (QOL) have become issues. As one of the main factors of this shortening of the healthy lifespan, a high-risk state requiring nursing care due to a disorder of the locomotor system, that is, a locomotive syndrome (locomotive syndrome) can be cited. Pain, muscle strength decline, stamina decline, and exercise speed decline due to motor system diseases that accompany aging occur, and these mutual influences are in a negative chain reaction. As a result, it becomes impossible to carry out activities of daily living, and it is considered that it wil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/7048A61P21/00
CPCA61K31/352A61K31/7048A61P21/00A61K31/353A61K9/0095A61K9/2059A61K9/0053A61K9/0056
Inventor 吉田大将大塚祐多
Owner SUNTORY HLDG LTD
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