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Application of pseudobulubs cremastrae seu pleiones extract in preparation of anti-drug resistant Acinetobacter baumannii drug

A technology of Acinetobacter baumannii and Arrowhead mushroom, applied to antibacterial drugs, plant/algae/fungus/moss components, pharmaceutical formulas, etc., to achieve the effect of convenient operation, fast method and low price

Active Publication Date: 2019-10-08
GENERAL HOSPITAL OF SOUTHERN THEATRE COMMAND OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are no reports on its antibacterial and anti-drug-resistant bacteria effects

Method used

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  • Application of pseudobulubs cremastrae seu pleiones extract in preparation of anti-drug resistant Acinetobacter baumannii drug
  • Application of pseudobulubs cremastrae seu pleiones extract in preparation of anti-drug resistant Acinetobacter baumannii drug

Examples

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Embodiment 1

[0026] Example 1 Preparation of Arrowhead Mushroom Extract and Detection of Its Antibacterial Activity

[0027] 1. Experimental method

[0028] 1. Preparation of Arrowhead Mushroom Extract

[0029] Weigh three parts of Arrowhead, each 2g, and place them in three 100mL round-bottomed flasks respectively, add water, 50% ethanol, and 95% ethanol three different solvents 24mL respectively according to the material ratio of 1:12; Flasks with different extraction solutions were set at different extraction temperatures of 100°C, 90°C, and 85°C, and were heated and refluxed for 1.5 hours to filter the medicinal solution; again, the corresponding extracts were added at a material ratio of 1:8, respectively, at 100°C , 90°C, and 85°C for 1.5 hours, filtered and combined all the liquid medicines, evaporated all the solvents under reduced pressure to obtain medicinal extracts, weighed and placed in a 1.5mL centrifuge tube, and placed in a -20°C refrigerator for later use. Three kinds of...

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Abstract

The invention discloses an application of a pseudobulubs cremastrae seu pleiones extract in preparation of an anti-drug resistant Acinetobacter baumannii drug. The application utilizes the pseudobulubs cremastrae seu pleiones extract to treat the nematode infected with the drug-resistant Acinetobacter baumannii, and shows that the pseudobulubs cremastrae seu pleiones extract has a good bactericidal effect on the drug-resistant Acinetobacter baumannii. The application provides a good preliminary research basis for the development of new anti-drug resistant Acinetobacter baumannii drugs, and brings a dawn to solve the dilemma of no available medicine clinically for drug-resistant Acinetobacter baumannii infection, the pseudobulubs cremastrae seu pleiones extract is used for prevention and treatment of the drug-resistant Acinetobacter baumannii, the method is fast, the price is cheap, and the operation is convenient.

Description

technical field [0001] The present invention relates to the field of biotechnology, and more specifically, relates to the application of the extract of Arrowhead mushroom in the preparation of anti-drug-resistant Acinetobacter baumannii medicaments. Background technique [0002] Acinetobacter baumannii is the most common non-fermenting Gram-negative bacterium in the Acinetobacter genus. The bacteria can survive for a long time in the hospital environment, and the distribution of clinical departments is mainly in the ICU, followed by the Department of Respiratory Medicine. Elderly patients, patients with weak body resistance and critical illness, as well as patients who use various invasive procedures and long-term treatment with broad-spectrum antibiotics are susceptible objects. Acinetobacter baumannii has the ability to rapidly acquire and spread drug resistance, drug-resistant Acinetobacter baumannii presents a worldwide epidemic trend, and has become one of the most imp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P31/04
CPCA61K36/898A61P31/04A61K2236/331
Inventor 李健姜志辉袁进黄涛阳张强尹雁刘璐蔡学究
Owner GENERAL HOSPITAL OF SOUTHERN THEATRE COMMAND OF PLA
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