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Application of lactic acid bacteria combined with medium-chain triglyceride in repairing intestinal inflammation

A technology for medium-chain triglycerides and intestinal inflammation, which is applied to medical preparations containing active ingredients, anti-inflammatory agents, drug combinations, etc., can solve problems such as unsatisfactory intestinal inflammation repair effect and unsatisfactory effect. , to reduce the level of inflammatory factors in small intestinal tissue, increase body weight, and improve the effect of repair

Inactive Publication Date: 2019-10-08
GENERAL HOSPITAL OF PLA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, the effect of simply using lactic acid bacteria as an enteral nutrition preparation is not particularly ideal, and other enteral nutrition preparations are not ideal for repairing intestinal inflammation, so it is particularly important to develop a new type of intestinal inflammation repair nutrition preparation important

Method used

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  • Application of lactic acid bacteria combined with medium-chain triglyceride in repairing intestinal inflammation
  • Application of lactic acid bacteria combined with medium-chain triglyceride in repairing intestinal inflammation
  • Application of lactic acid bacteria combined with medium-chain triglyceride in repairing intestinal inflammation

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Embodiment Construction

[0022] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention are clearly and completely described. Obviously, the described embodiments are part of the embodiments of the present invention, not all of them. example. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0023] 1 Materials and methods

[0024] 1.1 Establishment and grouping of experimental animal models

[0025] The source of experimental mice: SPF grade healthy 12-week-old male C57BL / 6J mice, provided by the Institute of Experimental Animals, Chinese Academy of Medical Sciences, the production license number is SCXK (Beijing) 2014-0004, and the use license number is SYXK (army) 2012-0010.

[0026] Determination of the dosage of...

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Abstract

The invention provides an application of lactic acid bacteria combined with medium-chain triglyceride in repairing intestinal inflammation. The application is characterized in that the lactic acid bacteria combined with medium-chain triglyceride is used for repairing intestinal inflammation, preparing intestinal inflammation repair drugs or preparing enteral nutrition preparations. The applicationhas the following advantages that the application of the lactic acid bacteria combined with medium-chain triglyceride in repairing intestinal inflammation can obviously increase the weight of mice inan intestinal inflammation experimental group, play a certain nutritional supplement role, can significantly reduce the levels of TNF-alpha, IL-1beta, IL-6, MCP-1 in serum and small intestinal tissues, and further significantly reduce the mRNA expression levels of TLR4, MyD88, NF-kB in small intestinal tissues; the pathological section of small intestine tissue shows that the application has a good repair effect on small intestine mucosa injury of mice; and the application provides a good choice for developing nutritional preparations for repairing intestinal inflammation of patients with severe infection.

Description

technical field [0001] The invention belongs to the technical field of intestinal inflammation repair medicine research, and relates to an application of lactic acid bacteria combined with medium-chain triglycerides, in particular to an application of lactic acid bacteria combined with medium-chain triglycerides in repairing intestinal inflammation. Background technique [0002] Severe infection is a complex clinical syndrome characterized by organ dysfunction caused by systemic infection, often leading to multiple organ dysfunction syndrome (Multi-organ dysfunction syndrome, MODS), in which intestinal inflammation is the main manifestation of severe infection. [0003] The intestine is one of the important organs to maintain normal physiological activities of the human body. It participates in important functions such as the body's material metabolism, defense barrier, cellular humoral immunity, and secretion of active substances. It is the most powerful "digestion factory" ...

Claims

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Application Information

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IPC IPC(8): A61K35/744A61K35/747A61P1/00A61P29/00A61K35/745A61K31/22
CPCA61K35/744A61K31/22A61K35/745A61K35/747A61P1/00A61P29/00A61K2300/00
Inventor 刘英华刘鹿孙狄张永张碰徐庆张新胜
Owner GENERAL HOSPITAL OF PLA
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