Contact lens visual eye pressure sensor based on strain sensing mechanism and preparation thereof

Abstract

The invention belongs to the field of eye pressure sensing, and discloses a contact lens visual eye pressure sensor based on a strain sensing mechanism and preparation thereof. The sensor comprises acornea contact lens (1) formed through conformal bonding, a micro-cavity (2), a sensing channel (3) and an air chamber (4). The micro-cavity is fully filled with dyeing function liquid (6). One end ofthe sensing channel is communicated with the air chamber, and the other end of the sensing channel is connected with the micro-cavity. The sensing channel is used for balancing the pressure between the air chamber and the micro-cavity. When the eye pressure changes, the deformation of the micro-cavity is caused, and the pressure difference is generated between the air chamber and the micro-cavity. By monitoring the position of a gas-liquid interface in the sensing channel, the eye pressure can be monitored. The soft curved surface microfluidic contact eye is prepared through conformal bondingand internally provided with the micro-cavity, the sensing micro-channel and the air chamber, and the contact eye is simple in structure, convenient to use, soft and comfortable to wear, high in sensitivity, large in dynamic range and quite suitable for the eye pressure sensing field.

Description

technical field [0001] The invention belongs to the field of intraocular pressure sensing, and more specifically relates to a contact lens visual intraocular pressure sensor based on a strain sensing mechanism and a preparation method thereof. The contact lens visual sensor based on a strain sensing mechanism can be realized by conformal bonding. The preparation of the intraocular pressure sensor, and the contact lens visual intraocular pressure sensor based on the strain sensing mechanism can cooperate with the back-end wireless monitoring function module to realize continuous monitoring of intraocular pressure for 24 hours. Background technique [0002] Glaucoma is the world's first irreversible blinding eye disease. Medical practice has found that elevated intraocular pressure is not the only risk factor for glaucoma damage. Pathological intraocular pressure fluctuations also play an important role in the development of glaucoma, and its manifestations are more hidden. T...

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Problems solved by technology

However, further studies have shown that 1) the wearing comfort is poor; 2) the sensitivity and detection accuracy of the sensor are not enough; 3) the output signal is unstable, which limits its clinical promotion

A variable inductance 24-hour intraocular pressure monitor developed in Hong Kong (see "Soft wearablecontact lens sensor for continuous intraocular pressure monitoring", Guo-ZhenChen, Ion-Seng Chan, Leo K.K.Leung, David C.C.Lam. The Hong Kong University of Science and Technology, Hong Kong.) realizes the 24-hour measurement of intraocular pressure based on the principle of inductance change, but because it uses metal copper foil as the inductance coil material, because the mechanical scale of copper foil is much larger than that of contact lens materials and human eye materials, As a result: 1) It is very difficult to couple the sensing unit into the contact lens; 2) Due to the extremely large elastic modulus of the copper foil, the diameter change of the inductance coil caused by intraocular pressure fluctuations is very small, and the inductance change is small, resulting in extremely low sensitivity of the sensor; 3) Hard copper foil leads to very poor wearing comfort of the sensor, which will affect the deformation of the cornea in the wearing area with changes in the eye

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