Porous PCL-TCP (polycaprolactone-tricalcium phosphate) artificial bone scaffold with drug sustained release function and preparation method of porous PCL-TCP artificial bone scaffold

Abstract

The invention provides a preparation method of a porous PCL-TCP (polycaprolactone-tricalcium phosphate) artificial bone scaffold with a drug sustained release function. The PCL-TCP artificial bone scaffold prepared with the method has biological activity and regular pore diameter, the porosity is higher than or equal to 60%, the pore diameter is in a range of 300-500 mu m, the compressive strength is higher than or equal to 20 MPa, the compression modulus is 0.5-1 GPa, the degradation time of the PCL-TCP artificial bone scaffold is gradually prolonged from the edge layer to the middle layer, the degradation time of the middle layer of the scaffold is 1-3 years, the degradation time of the edge layer is 2-6 months, besides, composite printing with chitosan microspheres / collagen wires is performed, chitosan microspheres wrap a drug for promoting bone formation, and the sustained release function of the drug is played. The prepared PCL-TCP artificial bone scaffold has elasticity modulus and mechanical strength which are close to those of natural bone tissue, a porous structure and the chitosan microspheres in the porous structure can realize sustained release of the drug for promoting bone formation, new bone tissue is induced to grow, the problem about bone-material interface bonding is solved, a good osseointegration effect is realized, the PCL-TCP artificial bone scaffold has better mechanical compatibility and osseointegration capacity than a metal material, and the ideal material and preparation method are provided for overcoming poor bone healing of a patient with bone defects.

Description

technical field [0001] The invention belongs to the field of bone fusion internal fixation for large segmental bone defects, and in particular relates to a porous PCL-TCP artificial bone support with drug slow release function and a preparation method thereof. Background technique [0002] At present, the methods used clinically to treat bone defects include autologous bone graft, allogeneic bone graft and artificial bone scaffold graft. Autologous bone grafts cause damage to the patient's donor site; the source of allogeneic bone grafts is limited, with potential risks of disease transmission and immune rejection; degradable artificial bone scaffolds overcome the defects of autologous bone and allogeneic bone, but currently commonly used tricalcium phosphate (tricalcium phosphate) Phosphate, TCP), polycaprolactone (polycaprolactone, PCL), poly L-lactic acid (poly (L-lactic acid), PLLA) and poly lactic acid-glycolic acid (poly (lactic acid-hydroxyacetic acid), PLGA) and othe...

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Problems solved by technology

[0004] The main reason why diabetes makes it difficult to heal bone defects is that the disorder of blood sugar produces blood sugar oxidation products that destroy the microvascular and muscle endocrine functions of bone tissue, thereby reducing the activity of osteoblasts and bone reconstruction function, resulting in cortical bone microporosity and decreased bone strength.

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