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Application of arrowshaped tinospora root extractive in preparation of antagonizing drug-resistant acinetobacter baumannii drug

A technology of extracts of Acinetobacter baumannii and Lavenderia, which is applied in antibacterial drugs, plant/algae/fungus/moss components, pharmaceutical formulations, etc., to achieve the effect of convenient operation, fast method and low price

Inactive Publication Date: 2019-09-24
GENERAL HOSPITAL OF SOUTHERN THEATRE COMMAND OF PLA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its effect on drug-resistant bacteria, especially drug-resistant Acinetobacter baumannii, has not yet been reported.

Method used

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  • Application of arrowshaped tinospora root extractive in preparation of antagonizing drug-resistant acinetobacter baumannii drug
  • Application of arrowshaped tinospora root extractive in preparation of antagonizing drug-resistant acinetobacter baumannii drug

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Embodiment 1

[0026] The preparation of embodiment 1 golden fruit extract and the detection of antibacterial activity thereof

[0027] 1. Experimental method

[0028] 1, the preparation of the extract of Lavender

[0029] Weigh three parts of Lavender, each 2g, and place them in three 100mL round-bottomed flasks respectively, and add 24mL of water, 50% ethanol, and 95% ethanol to three different solvents at a material ratio of 1:12; Flasks with different extraction solutions were set at different extraction temperatures of 100°C, 90°C, and 85°C, and were heated and refluxed for 1.5 hours to filter the medicinal solution; again, the corresponding extracts were added at a material ratio of 1:8, respectively, at 100°C , 90°C, and 85°C for 1.5 hours, filtered and combined all the liquid medicines, evaporated all the solvents under reduced pressure to obtain medicinal extracts, weighed and placed in a 1.5mL centrifuge tube, and placed in a -20°C refrigerator for later use. Three kinds of extra...

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Abstract

The invention discloses application of arrowshaped tinospora root extractive in preparation of an antagonizing drug-resistant acinetobacter baumannii drug. A nematode model infected with drug-resistant acinetobacter baumannii is used for treatment research, a result shows that the arrowshaped tinospora root extractive has a good internal bactericidal effect on the drug-resistant acinetobacter baumannii, a good preliminary research basis is provided for researching and developing the novel antagonizing drug-resistant acinetobacter baumannii drug, and the daylight is brought for solving the problem that no drug is available for clinically drug-resistant acinetobacter baumannii infection. The arrowshaped tinospora root extractive is used for preventing and curing the drug-resistant acinetobacter baumannii, the method is rapid, price is low, and the operation is convenient and fast.

Description

technical field [0001] The invention relates to the field of biotechnology, and more specifically, relates to the application of the extract of Aurea oleracea in the preparation of anti-drug-resistant Acinetobacter baumannii medicaments. Background technique [0002] Acinetobacter baumannii is the most common non-fermenting Gram-negative bacterium in the Acinetobacter genus. The bacteria can survive for a long time in the hospital environment, and the distribution of clinical departments is mainly in the ICU, followed by the Department of Respiratory Medicine. Elderly patients, patients with weak body resistance and critical illness, as well as patients who use various invasive procedures and long-term treatment with broad-spectrum antibiotics are susceptible objects. Acinetobacter baumannii has the ability to rapidly acquire and spread drug resistance, drug-resistant Acinetobacter baumannii presents a worldwide epidemic trend, and has become one of the most important patho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/59A61P31/04A61K125/00
CPCA61K36/59A61K2236/331A61P31/04
Inventor 姜志辉石磊苏澎季波袁进杨晓敏蔡敏捷
Owner GENERAL HOSPITAL OF SOUTHERN THEATRE COMMAND OF PLA
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