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Application of homoharringtonine in treatment of breast tumors

A homoharringtonine, breast tumor technology, applied in the field of tumor molecular biology, can solve problems such as restricted development and breast damage

Inactive Publication Date: 2019-09-20
GENERAL HOSPITAL OF NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the lack and damage of breasts caused by surgical resection, its clinical development is also limited. Targeted therapy drugs are a highly specific therapy, and screening good drugs and treatment sites is a key area of ​​our research

Method used

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  • Application of homoharringtonine in treatment of breast tumors
  • Application of homoharringtonine in treatment of breast tumors
  • Application of homoharringtonine in treatment of breast tumors

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Embodiment Construction

[0026] The present application provides the application of homoharringtonine in the treatment of breast tumors.

[0027] The application provides the application of homoharringtonine in inhibiting the proliferation and metastasis of breast tumor cells.

[0028] The application provides the application of homoharringtonine in inhibiting the proliferation and metastasis of breast tumor cells or treating breast tumors.

[0029] Further, the dosage form of the medicine includes soft capsule, dropping pill, emulsion, tablet, lotion, liniment, ointment or suppository.

[0030] The present application proves that homoharringtonine can inhibit the proliferation and metastasis of breast tumor cells, and has the function of treating breast tumors. The present application found that homoharringtonine can significantly inhibit the proliferation and cell colony formation of two breast cancer cells MDA-MB-231 and MCF-7 cells, and can also significantly inhibit the migration ability of two ...

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Abstract

The application discloses application of homoharringtonine in the treatment of breast tumors. It is verified herein that homoharringtonine can inhibit proliferation and metastasis of breast tumor cells and treat breast tumors. It is discovered herein that homoharringtonine can inhibit evidently the proliferation of two breast cancer cells MDA-MB-231 and MCF-7 and the formation of cell colonies, and can also inhibit evidently the ability of the two breast cancer cells to migrate. After homoharringtonine acts, evident morphological changes of apoptosis occur to the cells, and mortality of the cells rises evidently. Homoharringtonine can inhibit the size of breast tumors in a mouse and inhibit the proliferation of the tumors. The influence of homoharringtonine upon the proliferation, migration and apoptosis of breast cancer cells is studied herein; homoharringtonine has the function of treating breast tumors.

Description

technical field [0001] The application relates to the technical field of tumor molecular biology, in particular to the application of homoharringtonine in the treatment of breast tumors. Background technique [0002] Breast cancer treatments mainly include surgical resection, radiation exposure, and chemotherapy drugs. However, due to the lack and damage of the breast caused by surgical resection, its clinical development is also limited. Targeted therapy drugs are a highly specific therapy. Screening good drugs and treatment sites is a key area of ​​our research . At present, clinical targeted therapy drugs mainly exert anti-tumor effects by inducing tumor cell apoptosis, and the anti-cancer mechanism of most existing chemotherapy drugs is closely related to tumor cell apoptosis. [0003] Homoharringtonine (Homoharringtonine, HHT) is a natural and effective cell cycle non-specific anti-tumor plant alkaloid, derived from a plant of the genus Taxus, with a molecular formula...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/55A61K36/13A61P35/00A61P35/04
CPCA61K31/55A61K36/13A61P35/00A61P35/04
Inventor 王立斌王丹妮
Owner GENERAL HOSPITAL OF NINGXIA MEDICAL UNIV
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