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Preparation method of molecularly imprinted sensor based on carbon quantum dot/hollow nickel base material composite film modified glassy carbon electrode and application thereof

A glassy carbon electrode and carbon quantum dot technology, which is applied in the field of electrochemical sensor preparation, can solve problems such as defects, electrode electrocatalytic activity and active area need to be further improved, etc., and achieves simple operation, improved electron transfer performance, and improved active area. Effect

Inactive Publication Date: 2019-09-06
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The Chinese patent CN108645903 "Preparation and Application of Molecular Imprinted Sensor Based on Carbon Dot-Chitosan Modified Glassy Carbon Electrode" applied by the inventor is an exploration based on the above characteristics, but there are still flaws. The electrocatalytic activity and activity of the electrode Area needs to be further improved

Method used

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  • Preparation method of molecularly imprinted sensor based on carbon quantum dot/hollow nickel base material composite film modified glassy carbon electrode and application thereof
  • Preparation method of molecularly imprinted sensor based on carbon quantum dot/hollow nickel base material composite film modified glassy carbon electrode and application thereof
  • Preparation method of molecularly imprinted sensor based on carbon quantum dot/hollow nickel base material composite film modified glassy carbon electrode and application thereof

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Experimental program
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Effect test

Embodiment 1

[0031] a) Preparation of modified electrode: The Ni-Cu alloy layer was prepared by a three-electrode system containing 1.0 M NiSO 4 , 0.01 M CuSO 4 and 0.5 M H 3 BO 3 Electrodeposited on the treated glassy carbon electrode in the mixed solution, and then dealloyed in the same solution to remove copper to prepare nanometer hollow nickel sphere layer. Put pure cotton material with a mass ratio of 1:40 and distilled water in a reaction vessel, heat at 180° C. for 12 hours, and cool to room temperature to obtain a solution of carbon quantum dots. The solution containing the carbon quantum dots is filtered, centrifuged, and freeze-dried to obtain the solid-state fluorescent carbon quantum dots. Mix it with 1% chitosan acetic acid solution at a ratio of 1:1, drop-spray 5 μL on the surface of a glassy carbon electrode coated with a hollow nickel ball, dry it in an oven at 60°C for 30 minutes, and cool it to room temperature to obtain the modification. electrode.

[0032] b) Prep...

Embodiment 2

[0034] a) Preparation of modified electrode: The Ni-Cu alloy layer was prepared by a three-electrode system containing 1.0 M NiSO 4 , 0.01 M CuSO 4and 0.5 M H 3 BO 3 Electrodeposited on the treated glassy carbon electrode in the mixed solution, and then dealloyed in the same solution to remove copper to prepare nanometer hollow nickel sphere layer. Put pure cotton material with a mass ratio of 1:50 and distilled water in a reaction vessel, heat at 190° C. for 14 hours, and cool to room temperature to obtain a solution of carbon quantum dots. The solution containing the carbon quantum dots is filtered, centrifuged, and freeze-dried to obtain the solid-state fluorescent carbon quantum dots. Mix it with 1% chitosan acetic acid solution at a ratio of 2:1, drop-spray 10 μL on the surface of the glassy carbon electrode coated with hollow nickel balls, dry in an oven at 60°C for 30 minutes, and cool to room temperature to obtain the modification. electrode.

[0035] b) Preparati...

Embodiment 3

[0037] a) Preparation of modified electrode: The Ni-Cu alloy layer was prepared by a three-electrode system containing 1.0 M NiSO 4 , 0.01 M CuSO 4 and 0.5 M H 3 BO 3 Electrodeposited on the treated glassy carbon electrode in the mixed solution, and then dealloyed in the same solution to remove copper to prepare nanometer hollow nickel sphere layer. Put pure cotton material with a mass ratio of 1:60 and distilled water in a reaction vessel, heat at 200°C for 15 hours, and cool to room temperature to obtain a solution of carbon quantum dots. The solution containing the carbon quantum dots is filtered, centrifuged, and freeze-dried to obtain the solid-state fluorescent carbon quantum dots. Mix it with 1% chitosan acetic acid solution at a ratio of 3:1, drop-spray 9 μL on the surface of the glassy carbon electrode coated with hollow nickel balls, dry in an oven at 60°C for 30 minutes, and cool to room temperature to obtain the modification. electrode.

[0038] b) Preparation...

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Abstract

The invention belongs to the technical field of preparation of electrochemical sensors, and relates to a preparation method of a molecularly imprinted sensor based on a carbon quantum dot / a hollow nickel base material composite film modified glassy carbon electrode. The preparation method comprises the following steps of firstly depositing a Ni-Cu alloy layer in a three-electrode system, and thendealloying and removing copper to obtain a nano hollow nickel sphere layer; preparing an environment-friendly carbon quantum dot solution by adopting a biomass material, and modifying a glassy carbonelectrode coated with a nano hollow nickel sphere by using a composite solution of the carbon quantum dot and chitosan; and taking 3-aminophenylboronic acid as a functional monomer, and preparing themolecular imprinted sensor which has specific recognition response to the template molecular glucose on the surface of the glassy carbon electrode modified by a composite film through an electrochemical polymerization method. The preparation method of the molecularly imprinted sensor based on the carbon quantum dot / the hollow nickel base material composite film modified glassy carbon electrode provided by the invention effectively improves the active area and the electron transport performance. Combined with the molecular imprinting technology, the molecularly imprinted sensor with specific recognition response to glucose is prepared, and the molecularly imprinted sensor has the advantages of being simple in operation, low in cost, high in selectivity and sensitivity, and is expected to bepractical.

Description

technical field [0001] The invention belongs to the technical field of electrochemical sensor preparation, is suitable for preparing a sensor for detecting glucose without enzymes, and relates to a preparation method and application of a molecular imprinted sensor based on a carbon quantum dot / hollow nickel-based material composite film modified glassy carbon electrode. Background technique [0002] Glucose is the energy source of cells and one of the most important biological species for diagnosing diabetes. Diabetes caused by long-term hyperglycemia and its complications has aroused great concern. In recent years, like other countries in the world, the prevalence of diabetes in my country is gradually increasing, and the impact of diabetes on the health of our people is becoming more and more serious. In addition, glucose is a common reactant and intermediate product in the microbial fermentation process, and it is one of the most important indicators to be controlled in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/327
CPCG01N27/308G01N27/3278
Inventor 邱凤仙郑伟吴海燕张涛徐吉成
Owner JIANGSU UNIV
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