Calcium phosphate cement containing decalcified bone matrix, and preparation method and applications thereof

A technology of calcium phosphate bone cement and decalcified bone matrix, which is applied in the fields of medical science, prosthesis, tissue regeneration, etc., can solve problems such as limited supply, need for secondary surgery, immune rejection, etc., and achieve good osteogenesis, Meet clinical needs and improve the effect of degradation performance

Inactive Publication Date: 2019-09-06
湖北联结生物材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional bone repair methods mainly include autologous bone and allogeneic bone transplantation, but there are problems such as immune rejection, limited supply sources, and the need for secondary surgery

Method used

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  • Calcium phosphate cement containing decalcified bone matrix, and preparation method and applications thereof
  • Calcium phosphate cement containing decalcified bone matrix, and preparation method and applications thereof
  • Calcium phosphate cement containing decalcified bone matrix, and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A calcium phosphate bone cement containing demineralized bone matrix (DBM), prepared by the following method:

[0027] (1) Weigh 64g of citric acid and 1.5g of sodium alginate, add the above two raw materials into 10ml of deionized water, dissolve to obtain a liquid phase, and store at room temperature for later use;

[0028] (2) Micron spherical heavy calcium carbonate, α-tricalcium phosphate (α-TCP), β-tricalcium phosphate (β-TCP), anhydrous calcium hydrogen phosphate (DCPA), hydroxyapatite (HA ), and micron flake DBM in a small mortar according to the mass ratio of 3:3:3:3:1:0.1, and then accurately measure the liquid phase according to the solid-liquid ratio of 1:0.4, and add the liquid phase to The solid phase powder was mixed quickly and evenly, and then filled into a mold with a length, width, and height of 1 cm, and solidified under the conditions of 37 ° C and 95% humidity to obtain a calcium phosphate bone cement containing DBM.

Embodiment 2

[0030] A calcium phosphate bone cement containing demineralized bone matrix (DBM), prepared by the following method:

[0031] (1) Weigh 64g citric acid, 1.5g chitosan, add above-mentioned two kinds of raw materials into 10ml deionized water, dissolve, obtain liquid phase, store at room temperature for subsequent use;

[0032] (2) Micron spherical heavy calcium carbonate, α-tricalcium phosphate (α-TCP), β-tricalcium phosphate (β-TCP), anhydrous calcium hydrogen phosphate (DCPA), hydroxyapatite (HA ), and micron-scale flake DBM in a small mortar according to the mass ratio of 3:3:3:3:1:0.5, and then accurately measure the liquid phase according to the solid-liquid ratio of 1:0.5, and add the liquid phase to the solid The phase powder was mixed quickly and evenly, and then filled into a mold with a length, width and height of 1 cm, and solidified under the conditions of 37 ° C and 95% humidity to obtain calcium phosphate bone cement containing DBM.

Embodiment 3

[0034] A calcium phosphate bone cement containing demineralized bone matrix (DBM), prepared by the following method:

[0035] (1) Weigh 32g citric acid, 2.0g chitosan, add above-mentioned two kinds of raw materials into 10ml deionized water, dissolve, obtain liquid phase, store for subsequent use at room temperature;

[0036] (2) Micron spherical light calcium carbonate, α-tricalcium phosphate (α-TCP), β-tricalcium phosphate (β-TCP), anhydrous calcium hydrogen phosphate (DCPA), hydroxyapatite (HA ), and millimeter-scale flake DBM in a small mortar according to the mass ratio of 3:3:3:3:1:2.0, and then accurately measure the liquid phase according to the solid-liquid ratio of 1:0.6, and add the liquid phase to the solid The phase powder was mixed quickly and evenly, and then filled into a mold with a length, width and height of 1 cm, and solidified under the conditions of 37 ° C and 95% humidity to obtain calcium phosphate bone cement containing DBM.

[0037] The obtained DBM-co...

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Abstract

The invention belongs to the field of bone damage repair biomedical materials, and specifically relates to calcium phosphate cement containing a decalcified bone matrix, and a preparation method and applications thereof. The cement consists of a solid phase and a liquid phase; the solid phase is formed by compounding calcium carbonate and calcium phosphate salt (alpha-tricalcium phosphate, beta-tricalcium phosphate, anhydrous calcium hydrogen phosphate and hydroxyapatite) with DBM, and the mass ratio of the calcium carbonate, the calcium phosphate salt and the DBM is 3 : 10 : 0.1 - 3 : 10 : 4;and the ratio of solid to liquid is 1 : 0.4 - 1 : 0.6. The cement containing the DBM has good injection types, anti-collapsibility, osteoconductivity, osteoinductivity and cell activity and good biodegradability, so that the cement is suitable for orthopedic injury repairing.

Description

technical field [0001] The invention belongs to the field of biomedical materials for bone damage repair, and in particular relates to a calcium phosphate bone cement containing decalcified bone matrix (DBM) and a preparation method and application thereof. Background technique [0002] Clinically, the number of patients with bone defects due to aging, tumors, trauma, osteomyelitis, and bone diseases is increasing year by year, and the demand for bone defect repair materials is increasing. Traditional bone repair methods mainly include autologous bone and allogeneic bone transplantation, but there are problems such as immune rejection, limited supply sources, and the need for secondary surgery. With the development of biomaterials, artificial bone repair materials have attracted much attention. Calcium phosphate materials are used in various forms. Compared with block repair materials, calcium phosphate cement (Calcium Phosphate Cements, CPC) has good fluidity, self-curing ...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/02A61L27/12A61L27/20A61L27/58
CPCA61L27/025A61L27/12A61L27/20A61L27/3608A61L27/365A61L27/58A61L2430/02C08L5/08C08L5/04
Inventor 张旗代春初司旭祝超胡丽叶莹张铁
Owner 湖北联结生物材料有限公司
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