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Preparation method of enzyme-supporting bismuth selenide nanoparticles to release oxygen upon exposure to light

A technology of nanoparticles and bismuth selenide, which is applied in the field of preparation of bismuth selenide nanoparticles, can solve the problems of limiting glucose oxidase consumption of sugar and the like

Active Publication Date: 2019-09-06
SOUTHWEST UNIVERSITY
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Problems solved by technology

However, tumor hypoxia generated by irregular proliferation of cancer cells and incomplete growth of blood vessels in solid tumors limits the rate of glucose consumption by glucose oxidase

Method used

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  • Preparation method of enzyme-supporting bismuth selenide nanoparticles to release oxygen upon exposure to light
  • Preparation method of enzyme-supporting bismuth selenide nanoparticles to release oxygen upon exposure to light
  • Preparation method of enzyme-supporting bismuth selenide nanoparticles to release oxygen upon exposure to light

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Embodiment 1

[0030] Example 1 Preparation of enzyme-loaded bismuth selenide nanoparticles that release oxygen under light

[0031] The flowchart of the synthesis of enzyme-loaded bismuth selenide nanoparticles that release oxygen under light is shown in figure 1 shown, including the following steps:

[0032] (1) Bi 2 Se 3 Preparation of NPs: First, 7.5×10 -4 Add 10 mL of bismuth nitrate pentahydrate into 10 mL of dilute nitric acid solution with a concentration of 1 mol / L, and stir evenly with magnetic force at room temperature to completely dissolve it. Add 2.7×10 to the above system -3 mol / L sodium hydroxide and 2×10 -5 mol / L surface modifier polyvinylpyrrolidone, then add 50 mL of ethylene glycol, stir magnetically at room temperature until it dissolves, and then transfer to the reaction kettle. After heating at 150 °C for 3 h, the obtained milky white solution was centrifuged at 8000 rpm for 12 min, washed with deionized water three times, and centrifuged to obtain bismuth ox...

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Abstract

The invention discloses a preparation method of enzyme-supporting bismuth selenide nanoparticles to release oxygen upon exposure to light, and relates to the field of synthesis in pharmaceutical chemistry, in particular to a method, including the steps, such as synthesizing hollow mesoporous bismuth selenide, synthesizing enzyme-supporting bismuth selenide, and loading perfluorocarbon. The preparation method of the enzyme-supporting bismuth selenide nanoparticles to release oxygen upon exposure to light comprises the specific steps of (1) synthesizing bismuth selenide through a hydrothermal process; (2) synthesizing glucose oxidase adsorbed to hollow mesoporous bismuth selenide shells by means of an ion adsorbing process; (3) filling bismuth selenide cavities with perfluorocarbon through an ultrasonic process, and filling with oxygen. A composite nano-drug delivery system acquired herein has the advantages of precision control of oxygen release, good photothermal properties, good biocompatibility and the like.

Description

technical field [0001] The invention relates to the field of chemical medicines, in particular to the preparation and use of bismuth selenide nano-particles with combined therapy of releasing oxygen by light and light-heat and starvation treatment. Background technique [0002] For photothermal therapy, the development of photothermal conversion agents with excellent properties is the key to achieve effective photothermal therapy. At present, various types of photothermal conversion agents such as metal nanomaterials, carbon nanomaterials, and organic materials are widely used in the photothermal therapy of tumors. Among them, bismuth selenide nanoparticles have become a potential photothermal therapy platform due to their excellent thermal stability and photothermal conversion efficiency. Bismuth selenide nanoparticles, with mesoporous and hollow lumens, can serve as potential drug carriers for drug delivery to tumor regions. This provides more possibilities for the appli...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K33/00A61K9/51A61K47/02A61K47/04A61P35/00
CPCA61K9/5115A61K33/00A61K41/0052A61P35/00A61K2300/00
Inventor 薛鹏任俊洁张蕾康跃军
Owner SOUTHWEST UNIVERSITY
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