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Application of cannabinoids in the preparation of drugs for inhalation

A technology for inhalation administration and cannabinoids, applied in the field of biomedicine, can solve problems such as narrow working range, and achieve the effects of short peak time, accurate single administration dose, and short inhalation administration time

Active Publication Date: 2022-02-08
HANYI BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to obtain the desired particle size suitable for aerosol administration with a spray pump, the viscosity of the formulation is critical, so the solvent:co-solvent working range is rather narrow

Method used

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  • Application of cannabinoids in the preparation of drugs for inhalation
  • Application of cannabinoids in the preparation of drugs for inhalation
  • Application of cannabinoids in the preparation of drugs for inhalation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1 Preparation of pills containing cannabinoids (20%)

[0066] a. Add 20 parts of cannabinoids (the mass percentage of CBD is 99.7%) and 80 parts of drug carrier PEG 6000 into a stirring container, heat to 65°C while stirring, melt the added materials into a feed liquid, and stir for 30 minutes until uniform;

[0067] b. Inject the material liquid into a spherical mold with a diameter of 10mm prepared in advance, and wait for it to cool to room temperature for molding;

[0068] c. Take off the mold after 1 hour, and take out the formed spherical pill.

Embodiment 2

[0069] Example 2 Preparation of pills containing cannabinoids (50%)

[0070] a. Add 50 parts of cannabinoid (the mass percentage of CBD is 99.7%) and 50 parts of drug carrier PEG 6000 into a stirring container, heat to 65°C while stirring, melt the added material into a feed liquid, and stir for 30 minutes until uniform;

[0071] b. Inject the material liquid into a spherical mold with a diameter of 10mm prepared in advance, and wait for it to cool to room temperature for molding;

[0072] c. Take off the mold after 1 hour, and take out the formed spherical pill.

Embodiment 3

[0073] Example 3 Preparation of pills containing cannabinoids (90%)

[0074] a. Add 90 parts of cannabinoids (the mass percentage of CBD is 99.7%) and 10 parts of drug carrier PEG 6000 into a stirring container, heat to 60°C while stirring, melt the added materials into a feed liquid, and stir for 30 minutes until uniform;

[0075] b. Inject the material liquid into a spherical mold with a diameter of 10mm prepared in advance, and wait for it to cool to room temperature for molding;

[0076] c. Take off the mold after 1 hour, and take out the formed spherical pill.

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Abstract

The invention discloses an application of cannabinoids in the preparation of a medicine for inhalation administration. The time for inhalation administration of the medicine is short, the time for inhalation administration of the medicine is less than 1 minute, the drug effect is rapidly exerted, and the time for reaching the peak of the blood drug concentration is short , high drug bioavailability.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of cannabinoids in the preparation of drugs for inhalation administration. Background technique [0002] Cannabis (scientific name: Cannabis sativa L.) is a plant belonging to the genus Moraceae, which has a long history of use as medicine. In 1997, the National Institutes of Health (NIH) published a report "Workshop on the Medical Utility of Marijuana" outlining the available scientific data on the therapeutic use of cannabis, recommending research to support the potential use of cannabis for the following medical indications: Stimulation Appetite and / or cachexia, nausea and vomiting after anticancer treatment, neurological and movement disorders, pain, and glaucoma. This was followed by the 1999 report "Marijuana and Medicine, Assessing the Science Base", which provided a review of the actual and potential therapeutic uses of cannabinoids. The need for a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/72A61K31/352A61K31/05A61P1/08A61P1/14A61P25/08A61P25/22A61P25/24A61P25/28A61P27/06A61P29/00
CPCA61K9/007A61K31/352A61K31/05A61P1/08A61P1/14A61P25/08A61P25/22A61P25/24A61P25/28A61P27/06A61P29/00
Inventor 谭昕范德凯王曙宾邢俊波孙武兴朱贝利
Owner HANYI BIO TECH CO LTD
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