Compound polypeptide nano vesicle and preparation method and application thereof

Abstract

The invention belongs to the technical field of cosmetics and provides a compound polypeptide nano vesicle and a preparation method and application thereof. The compound polypeptide nano vesicle comprises, by mass, 0.01-1% of hair growth promoting peptide, 0.01%-1% of hair root strengthening peptide, 0.01-1% of anti-inflammation antibacterial peptide, 0.01-1% of antioxidant active peptide, 0.1%-10% of a 5 alpha-reductase inhibitor, 0.5%-10% of a lipoid wall material, 0.1%-20% of an emulsifying agent, 0.1%-5% of cholesterol and 10-45% of polyalcohol. The compound polypeptide nano vesicle has advantages that the hair root strengthening peptide, the hair growth promoting peptide, the anti-inflammation antibacterial peptide, the antioxidant active peptide and the plant-derived 5 alpha-reductase inhibitor are jointly loaded in a same nano carrier, multi-target-point transdermal co-delivery of anti-hair-loss active components deep into hair follicles can be realized, synergistic effects areachieved, and dual efficacies including hair loss preventing and hair growth promoting are realized.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a composite polypeptide nanovesicle with hair growth and hair fixing functions, a preparation method and application thereof. Background technique [0002] With the acceleration of the pace of life and the increase of life pressure, more and more people are troubled by hair loss, and hair loss is showing a younger trend. 60% of men with hair loss show signs of hair loss before the age of 20, and the proportion of hair loss at the age of 30 is as high as 83.9%; the number of women with thinning hair is gradually increasing, and the phenomenon of hair loss is intensifying. Prevention and treatment of hair loss has become a difficult problem all over the world. [0003] The cause of hair loss is not yet very clear, but it has been found that hair loss is related to many factors such as heredity, endocrine, environmental deterioration, and mental psychology. Androgenetic alopecia ...

AI Technical Summary

Problems solved by technology

At present, there are many products containing anti-hair loss polypeptides, but the following problems generally exist: 1) The anti-hair loss mechanism is single and the efficiency is low: the product focuses on promoting hair growth, ignoring the comprehensive factors of fixing newly grown hair and preventing hair loss. Can not achieve high-efficiency anti-hair loss; 2) Poor solubility: such as diaminopyrimidine oxides, palmitoyl peptides, etc., have poor water solubility, so the hair growth liquid contains a large amount of alcohols, which can easily lead to dry scalp, itching, etc. after use. Comfortable experience; 3) Poor stability: Most anti-shedding polypeptides generally have poor stability in products, so that the polypeptides with high-efficiency activities cannot fully exert their anti-falling effects, and the products generated by the degradation of polypeptides in the product may also There are certain hazards to the human body; 4) Low absorption rate: Due to the skin's own barrier, most anti-shedding polypeptides are difficult to penetrate into the hair follicles and cannot directly act on the target site, so it is difficult to exert its hair growth and hair strengthening effects

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