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Oleracone H in purslane, extraction and separation method thereof, and application thereof

A separation method, the technology of purslane, applied in the direction of organic chemistry, drug combination, antineoplastic drugs, etc., can solve the problem of low structural novelty, and achieve the effect of environmentally friendly process method, simple and fast operation method

Active Publication Date: 2019-09-03
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • Oleracone H in purslane, extraction and separation method thereof, and application thereof
  • Oleracone H in purslane, extraction and separation method thereof, and application thereof
  • Oleracone H in purslane, extraction and separation method thereof, and application thereof

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Embodiment Construction

[0030] The present invention provides new compound, molecular formula is C 13 h 14 o 6 , named oleracone H chemical formula is: .

[0031] The new compound is named oleracone H according to the structure, and Table 1 is the NMR data of the new compound: 1 H-NMR with 13 C-NMR in deuterated DMSO.

[0032] Table 1 NMR data of the new compound ( 1 H-NMR with 13 C-NMR in deuterated DMSO).

[0033]

[0034] The structural identification of the compounds of the present invention can be referred to Figure 1-10 .

[0035] Oleracone H: Yellow-green powder, easily soluble in methanol. After spotting the sample on the silica gel thin-layer plate, spray the ferric chloride test solution and the spot turns blue. UV(MeOH)λ max : 288, 213 nm. IR (KBr) v max 2940, 1710, 1650, 1575, 1280, 1150, 1125, 940, 856, 815, 784 cm -1 . HRESI(+)TOFMS gives m / z: 267.0857 [M+H] + The quasi-molecular ion peak has a molecular weight of 267.0864. combine 1 H-NMR, 13 According to C-N...

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Abstract

The invention relates to the field of traditional Chinese medicine extraction and separation, in particular relates to a new flavonoid compound extracted, separated and identified from purslane and anextraction separation method and application thereof, and in particular relates to Oleracone H in purslane and an extraction separation method and application thereof. The molecular formula of the new compound is C13H14O6 and is named as Oleracone H. The extraction and separation method of the new compound sequentially comprises water decoction extraction, silica gel column chromatography, polyamide column chromatography, ODS medium pressure column and Sephadex LH-20 separation, and the new flavonoid compound is successfully extracted and separated, and is structurally identified as a new flavonoid compound by mass spectrometry, carbon spectrometry, hydrogen spectrometry and two-dimensional nuclear magnetic spectrum analysis methods. Studies show that the novel compound has anti-tumor andanti-oxidation effects, and the novel compound and salts or derivatives thereof can be used as precursor compounds for synthesizing other compounds, as well as raw materials for new drug developmentand pharmacological activity research, and can be used for preparing anti-tumor and anti-oxidation drugs.

Description

technical field [0001] The present invention relates to the field of extraction and separation of traditional Chinese medicine, in particular to a new compound extracted, separated and identified from purslane medicinal material and its extraction and separation method, specifically a compound Oleracone H in purslane and its extraction and separation method and application . Background technique [0002] purslane( Portulaca oleracea L.), also known as amaranth, longevity vegetable, ant vegetable, is an annual herb of the family Amaranthaceae. Purslane is widely distributed and rich in resources. It is one of the 78 wild plants with the same origin of medicine and food stipulated by the Ministry of Health of my country. Purslane is recorded in the 2015 edition of "Pharmacopoeia of the People's Republic of China". It has the functions of clearing heat and detoxifying, cooling blood and stopping bleeding, and stopping dysentery. , hemorrhoids, metrorrhagia, etc. [0003] M...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/22A61P35/00A61P39/06
CPCC07D311/22A61P35/00A61P39/06
Inventor 英锡相马懿飞张文洁赵程程
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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