Monobromo preparation method capable of improving yield of omega-bromohydrin-1

Abstract

The invention discloses a monobromo preparation method capable of improving the yield of omega-bromohydrin-1. The invention relates to chemical synthesis of a precursor namely the omega-bromohydrin-1of products like sex pheromone and prostaglandin of insects. The invention solves the problem of low yield of the omega-bromohydrin-1. The preparation method comprises the following concrete steps: placing reaction substrates namely 1,omega-alkanediol and hydrobromic acid, a catalyst and a solvent into a bottle A connected with a condenser tube; placing the solvent into a bottle B at the same time, carrying out heating, and maintaining boiling; allowing the bottle A to communicate with the bottle B through a branch tube, and allowing solvent vapor in the bottle B to enter the bottle A throughthe branch tube and to reflux into the bottle A under the action of condensation; and allowing generated omega-bromohydrin-1 to rise with the liquid level of the bottle A to enter the bottle B throughthe branch tube so as to timely separate a product from the reaction substrates. The method provided by the invention avoids generation of a by-product namely 1,omega-dibromoalkane, and improves theselectivity of a reaction and the final yield of the omega-bromohydrin-1.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis reactions, in particular to the chemical synthesis of ⍵-bromohydrin-1, which is an important precursor of natural products such as insect sex pheromones and prostaglandins, specifically a method for increasing the yield of ⍵-bromohydrin-1 Monobrominated preparation method. Background technique [0002] ⍵-Bromohydrin-1 is an important precursor for the synthesis of natural products such as insect sex pheromones and prostaglandins. The current reports on ⍵-Bromohydrin-1 mainly include Chen Zikang et al. In the synthesis, 8-bromo-1-octanol and 10-bromo-1-decanol were synthesized by heating reflux with octanediol, decanediol and hydrobromic acid as raw materials; Shao Hongbing et al. As a raw material, iodine was used as a catalyst to synthesize 6-bromo-1-hexanol by direct reflux method; Teng Youwei and others synthesized ω-bromoalcohol-1 by direct reflux method. [0003] The reflux metho...

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Problems solved by technology

[0004] The present invention overcomes the deficiencies in the prior art, and proposes a monobrominated preparation method that improves the yield of ⍵-bromohydrin-1, and solves the problem of the yield of ⍵-bromohydrin-1 due to the limitation of traditional reflux devices lower question

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