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Multifunctional medical materials and preparing method thereof

A multi-functional, foam material technology, applied in the direction of medical formula, medical science, bandages, etc., can solve the problems of easy to form anaerobic infection, no hemostasis, antibacterial, anti-inflammatory, and promote wound healing, etc., to achieve good broad-spectrum antibacterial, Good biocompatibility, effect of promoting hemostasis

Pending Publication Date: 2019-08-23
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Foam dressings currently on the market for negative pressure sealing drainage are mainly divided into two types: polyurethane (PU) foam and polyvinyl alcohol (PVA) foam, although PU and PVA porous foam dressings have good liquid absorption properties and can be used as negative pressure Conduction and drainage media, but PU and PVA materials themselves have been proven to have no biological functions such as hemostasis, antibacterial, anti-inflammatory, and promotion of wound healing, and when using a VSD system with PU or PVA as a foam matrix for a long time, it is easy to form anaerobic bacterial infection

Method used

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  • Multifunctional medical materials and preparing method thereof
  • Multifunctional medical materials and preparing method thereof
  • Multifunctional medical materials and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1】～【 Embodiment 10

[0048] 1. Embodiments 1 to 10 adopt method A to prepare multifunctional medical materials:

[0049] During the acetalization reaction of polyvinyl alcohol and formaldehyde, add a certain amount of quaternized chitin powder or quaternized chitosan powder with a certain degree of deacetylation and a certain degree of quaternary ammonium salt substitution, and then add foaming After co-reaction with sulfuric acid solution, polyvinyl alcohol-quaternized chitin / quaternized chitosan mixed foam (PVA / QCsF), i.e. polyvinyl alcohol-quaternized chitin mixed foam or Polyvinyl alcohol-quaternized chitosan hybrid foam.

[0050] Specific steps are as follows:

[0051] (1) Configure a PVA solution with a concentration of 5%-20%. First heat the water to 70-80°C with electric heating, add polyvinyl alcohol (PVA), stir until it dissolves until it becomes clear, and cool down to 25-30°C. Add quaternized chitin powder or quaternized chitosan powder whose mass is 5%-20% of the PVA material mass (...

Embodiment 11】～【 Embodiment 20

[0068] 1. Embodiments 11 to 20 adopt method B to prepare multifunctional medical materials:

[0069] First, a thin layer of loose spongy quaternized chitin non-woven fabric or quaternized chitosan non-woven fabric is covered on the wound, and then the polyvinyl alcohol foam used in the medical negative pressure closed drainage system is covered. The surface of the quaternized chitin non-woven fabric or the quaternized chitosan non-woven fabric is made of polyvinyl alcohol foam and the quaternized chitin / quaternized chitosan non-woven fabric together Composed of medical materials (PVAF+QCs), that is, medical materials composed of polyvinyl alcohol foam and quaternized chitin non-woven fabrics, or polyvinyl alcohol foam and quaternized chitosan non-woven fabrics medical material.

[0070] Specific steps are as follows:

[0071] (1) Get thin-layer loose spongy quaternized chitin nonwoven fabric or quaternized chitosan nonwoven material (deacetylation degree DD=0.03-0.99, quater...

Embodiment 21】～【 Embodiment 30

[0085] 1. Embodiments 21 to 30 adopt method C to prepare multifunctional medical materials:

[0086] First, quaternized chitin or quaternized chitosan is foamed separately to form quaternized chitin foam or quaternized chitosan foam, and then glued and fixed with medical polyvinyl alcohol foam. After the layers are perforated, they permeate and communicate with each other to obtain a double-layer medical foam material (PVAF+QCsF) composed of polyvinyl alcohol foam and quaternized chitin / quaternized chitosan foam, that is, polyvinyl alcohol foam and quaternary ammonium A double-layer medical foam material composed of salinized chitin foam, or a double-layer medical foam material composed of polyvinyl alcohol foam and quaternized ammonium salted chitosan foam.

[0087] The specific experimental steps are as follows:

[0088] (1) Configure 1% acetic acid solution containing 3wt%-5wt% quaternized chitin or quaternized chitosan (deacetylation degree DD=0.03-0.99, quaternary ammoni...

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Abstract

The invention belongs to the field of development of medical materials, and particularly relates to multifunctional medical materials and preparing methods thereof. The multifunctional medical materials are applied to a medical vacuum sealing drainage system and formed by compounding quaternary ammonium chitin / quaternary ammonium salted chitosan with polyvinyl alcohol, and the multifunctional medical materials are provided in three forms, namely (a) the polyvinyl alcohol-quaternary ammonium chitin / quaternary ammonium salted chitosan mixed foam material, (b) the medical material formed by polyvinyl alcohol foam and a quaternary ammonium chitin / quaternary ammonium salted chitosan non-woven fabric, and (c) the dual-layer medical foam material formed by polyvinyl alcohol foam and quaternary ammonium chitin / quaternary ammonium salted chitosan foam; meanwhile, the preparing methods of the multifunctional materials are provided. The prepared multifunctional medical materials have good biocompatibility and have good infection resistance, hemostasis performance and wound healing promotion performance compared with single liquid absorption functions of traditional medical foam materials.

Description

technical field [0001] The invention belongs to the field of medical material development, and in particular relates to a multifunctional medical material and a preparation method thereof. Background technique [0002] The correct treatment of surgical wounds is one of the keys to the success of surgical treatment, and good wound healing is the prerequisite for the recovery of body functions after trauma. At present, for ordinary wounds and surgical incisions, traditional dressings such as fiber gauze and cotton pads are still used most clinically. This kind of dressing can only protect the wound surface, and has poor moisturizing effect, and it is easy to cause exogenous infection when the dressing penetrates. . For diabetic foot, extensive burns, osteomyelitis, decubitus, infection and other difficult-to-heal wounds, the current clinical treatment method is negative pressure sealing drainage (Vaccum Sealing Drainage, VSD). The VSD system consists of a porous foam materia...

Claims

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Application Information

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IPC IPC(8): A61L15/42A61L15/28A61L15/24A61L15/46
CPCA61L15/225A61L15/24A61L15/28A61L15/42A61L15/425A61L15/46A61L2300/232A61L2300/412A61L2300/418A61L2400/04C08L5/08C08L29/04
Inventor 王彦峰夏天方泽鸿蔡杰张俐娜卞晓恩
Owner WUHAN UNIV
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