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Salvianolic acid A capsule type inspiration aerosol micropowder and preparing method thereof

A technology of inhaling powder and salvianolic acid, which is applied in the field of pharmaceutical preparations, can solve the problems of aggravating pharyngeal follicular hyperplasia, poor drug stability, and environmental pollution

Inactive Publication Date: 2019-08-23
ZHUHAI RESPROLY PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in the prior art, medicines in sprays and quantitative inhalation aerosols exist as liquids, and the stability of the medicines is poor. Quantitative inhalation aerosols must also use propellant-freon and other hydrofluoroalkane substances, which will not only cause environmental pollution, Moreover, it will stimulate the pharynx during use, causing or aggravating follicular hyperplasia in the pharynx
In addition, the high deposition rate in the lungs also affects the efficacy of the drug

Method used

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  • Salvianolic acid A capsule type inspiration aerosol micropowder and preparing method thereof
  • Salvianolic acid A capsule type inspiration aerosol micropowder and preparing method thereof
  • Salvianolic acid A capsule type inspiration aerosol micropowder and preparing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Put 5.0g of salvianolic acid A through the fluidized bed supersonic jet pulverization method to make the particle size reach d10=0.5-1.5μm, d50=1.5-4.0μm, d90=2.5-8.0μm, take 0.5g and dissolve it in ethanol , after filtration, the filtrate is spray-dried; take 10g of lactose whose particle size is d10=15-50 μm, d50=80-120 μm, d90=120-200 μm, mix it with the above-mentioned salvianolic acid A micro-powder in a granulator and pack it in capsules. .

Embodiment 2

[0034] According to the formula in Example 1, micronize salvianolic acid A with a fluid energy mill to make the particle size reach d10=0.5-1.5 μm, d50=1.5-4.0 μm, d90=2.5-8.0 μm, and change the carrier to the particle size For lactose with d10=20-40 μm, d50=90-110 μm, d90=120-180 μm, the powder spray was prepared according to the process of Example 1.

Embodiment 3

[0036] Put 5.0g of salvianolic acid A through the fluidized bed supersonic airflow pulverization method to make the particle size reach d10=0.5-1.5μm, d50=1.5-4.0μm, d90=2.5-8.0μm, take 0.1g and dissolve it in ethanol , after filtering, the filtrate is spray-dried; take 20g of lactose whose particle size is d10=15-50 μm, d50=80-120 μm, d90=120-200 μm, mix it with the above-mentioned salvianolic acid A micro-powder in a granulator and pack it in capsules.

[0037] The process conditions are as follows: inlet temperature is 105°C, outlet temperature is 68°C, air flow rate is 90%, nozzle outlet inner diameter is 0.1cm, nozzle air flow rate is 800ml / min, and sample injection speed is 50mL / h.

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Abstract

The invention discloses a salvianolic acid A capsule type inspiration aerosol micropowder. The micropowder is composed of a salvianolic acid A micropowder and a carrier micropowder and is characterized in that the salvianolic acid A micropowder has the particle size d10 of 0.5-1.5 micron, the particle size d50 of 1.5-4.0 micron and the particle size d90 of 2.5-8.0 micron, 95% of more of salvianolic acid A micropowder has the particle size smaller than 10 micron, the carrier micropowder has the particle size d10 of 15-50 micron, the particle size d50 of 80-120 micron and the particle size d90 of 120-200 micron, and the weight ratio of salvianolic acid A to the carrier micropowder is 1:(1-1000). The invention further discloses a preparing method of the salvianolic acid A capsule type inspiration aerosol micropowder. The pulmonary deposition rate of salvianolic acid A in the aerosol micropowder can be increased, the pulmonary deposition of the carrier micropowder is avoided, and the stability of the composition is improved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a salvianolic acid A capsule type inhalation powder and a preparation method thereof. Background technique [0002] Conventional drugs are divided into tablets, granules, capsules, injections and other dosage forms, all of which are drugs that are metabolized throughout the body, and the dosage of their efficacy will be affected by problems such as absorption. It is easy to cause side effects such as allergies. Pulmonary inhalation administration is a simple and effective route of administration for the treatment of lung diseases. Furthermore, the metabolism of the drug through the liver reduces the bioavailability and curative effect of the drug, so increasing the dosage will cause more side effects on the human body. [0003] Compared with other routes of administration, pulmonary administration has the advantages of large absorption surface area, rich blo...

Claims

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Application Information

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IPC IPC(8): A61K9/72A61K9/16A61K47/26A61K31/216
CPCA61K9/0075A61K9/1623A61K31/216
Inventor 陈永奇韩飞
Owner ZHUHAI RESPROLY PHARM TECH CO LTD
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