Lurasidone solid dispersion and preparation method thereof
A technology of solid dispersion and lurasidone, which is applied in the field of medicine, can solve the problems of delaying the patient's condition, affecting the curative effect, and decreasing bioavailability
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Embodiment 1
[0100] The specific prescription is shown in Table 7.
[0101] Table 7
[0102]
[0103] Weigh the components contained in the hot-melt process according to the prescription shown in Table 7, mix them thoroughly and add them to the powder feeder of the hot-melt extruder. ℃, 165℃, 165℃, 165℃, 160℃, the screw speed is set to 30rpm, hot-melt extrusion, the extruded product is cooled and crushed, the crushed material passes through a 60-mesh sieve, and the additive microcrystal is added according to the prescription The cellulose is mixed, and the resulting mixture is filled into capsules.
Embodiment 2
[0105] According to the prescription and preparation process of Example 1, the obtained granules are finally poured into the shell of enteric-coated capsules.
Embodiment 3
[0107] The specific prescription is shown in Table 8.
[0108] Table 8
[0109]
[0110]
[0111] Weigh the components contained in the hot-melt process according to the prescription shown in Table 8, mix them thoroughly and add them to the powder feeder of the hot-melt extruder. ℃, 170℃, 170℃, 170℃, 165℃, the screw speed is set to 30rpm, hot-melt extrusion, the extrudate is cooled and crushed, the crushed material passes through a 60-mesh screen, and the additive microcrystal is added according to the prescription Cellulose, mixed, filled with capsules.
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