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Medicine "Yutusu" for treating hyperplasia of mammary glands and preparation method and application thereof

A breast hyperplasia and drug technology, which is applied in the directions of pharmaceutical formulas, drug combinations, and medical preparations containing active ingredients, etc., can solve the problems of long-term use, repeated illness, and deterioration of patients who are not suitable for patients, and can reduce the number of lobular hyperplasia and occlude gonadal glands. The number of tubes, the price is cheap, the effect is good

Active Publication Date: 2019-08-06
深圳市仁福生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Based on these cognitions, there have been Chinese patent medicines for the treatment of breast addiction in Chinese medicine, such as Xiaojin Wan, Rupixiao, Xiaoyao Granules, Rukang Tablets, etc.; , Bupleurum or Prunella vulgaris and other drugs that have obvious toxicity to liver damage are not suitable for patients to take for a long time, and the discontinuation of these drugs will easily lead to relapse and further deterioration of the disease

Method used

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  • Medicine "Yutusu" for treating hyperplasia of mammary glands and preparation method and application thereof
  • Medicine "Yutusu" for treating hyperplasia of mammary glands and preparation method and application thereof
  • Medicine "Yutusu" for treating hyperplasia of mammary glands and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The preparation method of embodiment 1 " jade rabbit cake " preparation 1 comprises the following steps:

[0052] (1) Preparation of Ashitaba extract

[0053] Get 5kg of dry whole plant Ashitaba and pulverize it into powder that has passed through a 80-mesh sieve, put it into an extraction tank, add 25L of 80% (v / v) ethanol aqueous solution to it each time, and reflux extraction at 60°C for 2 times. Each time for 2 hours, the two extracts were combined, concentrated under reduced pressure, and freeze-dried to obtain 876.5 g of Ashitina extract powder, which was set aside.

[0054] (2) Preparation of malt extract

[0055] Take 3kg of dry malt (raw) and crush it into a powder that has passed through an 80-mesh sieve, put it into an extraction tank, add 15L of water to it each time, decoct twice at 60°C for 1.5 hours each time, and combine the two extractions solution, concentrated under reduced pressure, and freeze-dried to obtain 330.0 g of malt extract powder, which w...

Embodiment 2

[0060] The preparation method of embodiment 2 "Jade Rabbit Crisp" preparation 2 comprises the following steps:

[0061] (1) Preparation of Ashitaba extract

[0062] Get 5kg of dry whole plant Ashitaba and pulverize it into powder that has passed through a 80 mesh sieve, put it into an extraction tank, add 50L of 80% (v / v) ethanol aqueous solution to it each time, and reflux extraction at 80°C for 2 times, Each time for 1 hour, the two extracts were combined, concentrated under reduced pressure, and freeze-dried to obtain 1035.9 g of Ashitina extract powder, which was set aside.

[0063] (2) Preparation of malt extract

[0064] Take 3kg of dry malt (raw) and crush it into a powder that has passed through an 80-mesh sieve, put it into an extraction tank, add 30L of water to it each time, decoct twice at 80°C for 1 hour each time, and combine the two extractions solution, concentrated under reduced pressure, and freeze-dried to obtain 381.0 g of malt extract powder, which was s...

Embodiment 3

[0068] Example 3 Therapeutic Effect of "Yutu Crisp" Preparation 1 on Mammary Gland Hyperplasia in Rats

[0069] Non-pregnant female SD rats (provided by the Hubei Provincial Center for Disease Control and Prevention), weighing 180 g. Drink water and eat freely, keep the room temperature at 25±1°C, and the light-dark cycle is 12 hours.

[0070] (1) Modeling and administration of mammary gland hyperplasia

[0071] During the experiment period, the pelleted feed was fed, and the experimental period was entered after one week of observational feeding. Female SD rats were randomly divided into 5 groups (5 rats in each group): blank control group, model group, low dose group of "Yutu crisp" preparation 1, high dose group of "Yutu crisp" preparation 1, and Rupixiao group (Rupixiao is a drug composed of antlers, dandelion, kelp, Panax notoginseng, red peony root, seaweed, leaking reed, woody fragrance, scrophulariaceae, motherwort, Mildew Spatholobus, trigeminus, forsythia, gongluom...

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Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a medicine, Yutusu, for treating hyperplasia of mammary glands (known as lump in breast in traditional Chinese medicine) and a preparation method and application thereof. The medicine is prepared from an ethanol extract of Angelica keiskei, a water extract of malt and a water extract of hawthorn. By comparing the treatment of model rats with hyperplasia of mammary glands, the compound medicine "Yutusu" is found to be effective in: (1), reducing the serum estradiol content and increasingthe level of progesterone hormone in serum; (2), reducing the number of lobular hyperplasia in breast tissue; and (3), reducing the number of occlusive obstructed acini in the lobules of the breast tissue; and the medicine has a good effect of soothing the liver and eliminating lump in breast.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a drug "Yutu crisp" for treating hyperplasia of mammary glands and its preparation method and application. Background technique [0002] Mammary gland hyperplasia is the most common breast disease, which can occur in women of any age after the onset of puberty, and is most common in women aged 30-premenopause. Its incidence rate is as high as 60%, accounting for the first place in breast diseases. Mammary gland hyperplasia is a benign lesion of the mammary gland, which refers to the disorder of the normal structure of the mammary gland caused by the physiological hyperplasia and incomplete involution of the mammary gland lobules during the mature period or periodic changes. It is neither inflammation nor tumor. Obvious breast lumps and severe pain appear due to cycle and mood changes, and the course of the disease is long, slow, and easy to rela...

Claims

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Application Information

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IPC IPC(8): A61K36/8998A61P15/14
CPCA61K36/232A61K36/734A61K36/8998A61P15/14A61K2300/00
Inventor 李玉桑黄夏伶蒙莎莎宋佳唐和斌
Owner 深圳市仁福生物科技有限公司
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