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Chitosan/HA-based personalized cranial, maxillofacial and spinal repair material and preparation method thereof

A technology for repairing materials and chitosan, applied in the field of biomedicine, can solve problems such as insufficient mechanical properties, and achieve the effects of bone tissue regeneration, improved mechanical properties, and strong osteogenic ability.

Active Publication Date: 2019-08-02
福建吉特瑞生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a chitosan / HA-based personalized cranial, maxillofacial, and vertebral bone repair material and its preparation method to meet the strength requirements of bone defect repair at load-bearing parts in view of the insufficient mechanical properties of the current chitosan-based materials.

Method used

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  • Chitosan/HA-based personalized cranial, maxillofacial and spinal repair material and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0027] A preparation method of chitosan / HA-based personalized cranial, maxillofacial and vertebral bone repair materials, specifically comprising the following steps:

[0028] (1) Preparation of DCPD-CS mixed solution: mix chitosan with acetic acid solution with a volume concentration of 2%, and then filter to remove insoluble matter to obtain chitosan solution; then NaH 2 PO 4 Add the chitosan solution of step (1) to the solution, then add Ca(CH 3 COO) 2 The solution was vigorously stirred for 12 hours, then added lecithin, cholesterol and pectin to mix evenly, and then statically defoamed for 24 hours to obtain a mixed solution;

[0029] (2) Preparation of gel: Lay a layer of filter paper soaked in coagulation solution on the inner surface of the mold in advance, inject the mixed solution into the mold, then put it into the coagulation solution, take out the mold after 1 hour, and continue to precipitate for 5 hours to obtain white gel;

[0030] (3) Preparation of substr...

Embodiment 2

[0039] A preparation method of chitosan / HA-based personalized cranial, maxillofacial and vertebral bone repair materials, specifically comprising the following steps:

[0040] (1) Preparation of DCPD-CS mixed solution: mix chitosan with acetic acid solution with a volume concentration of 2%, and then filter to remove insoluble matter to obtain chitosan solution; then NaH 2 PO 4 Add the chitosan solution of step (1) to the solution, then add Ca(CH 3 COO) 2 The solution was vigorously stirred for 12 hours, then added lecithin, cholesterol and pectin to mix evenly, and then statically defoamed for 24 hours to obtain a mixed solution;

[0041](2) Preparation of gel: Lay a layer of filter paper soaked in coagulation solution on the inner surface of the mold in advance, inject the mixed solution into the mold, then put it into the coagulation solution, take out the mold after 1 hour, and continue to precipitate for 6 hours to obtain white gel;

[0042] (3) Preparation of substra...

Embodiment 3

[0050] A preparation method of chitosan / HA-based personalized cranial, maxillofacial and vertebral bone repair materials, specifically comprising the following steps:

[0051] (1) Preparation of DCPD-CS mixed solution: mix chitosan with acetic acid solution with a volume concentration of 2%, and then filter to remove insoluble matter to obtain chitosan solution; then NaH 2 PO 4 Add the chitosan solution of step (1) to the solution, then add Ca(CH 3 COO) 2 The solution was vigorously stirred for 12 hours, then added lecithin, cholesterol and pectin to mix evenly, and then statically defoamed for 24 hours to obtain a mixed solution;

[0052] (2) Preparation of the gel: Lay a layer of filter paper soaked in the coagulation solution on the inner surface of the mold in advance, inject the mixed solution into the mold, then put it into the coagulation solution, take out the mold after 1 hour, and continue the precipitation for 5.5 hours. A white gel was obtained;

[0053] (3) Pr...

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Abstract

The invention discloses a chitosan / HA-based personalized cranial, maxillofacial and spinal repair material and a preparation method thereof. The repair material is prepared by taking a DCPD-CS mixed solution, lecithin, cholesterol and pectin as raw materials; the mechanical property of a chitosan material is effectively improved; the highest bending strength reaches 173 MPa; the highest bending modulus reaches 8.6 GPA; the repair requirements on bone defects in bearing parts such as the cranium, the maxillofacial region, the spine and the limb bones are met. The material is good in biocompatibility, is degradable and absorbable, and can remarkably induce repair and regeneration of the bone defects, the disadvantage of long-term retention in vivo of nonabsorbable materials such as titaniumalloy and PEEK is avoided, and the problems that absorbable materials such as PLA are liable to produce inflammatory reactions, the bone-forming effect is poor, and the like are also avoided. According to the chitosan / HA-based personalized cranial, maxillofacial and spinal repair material and the preparation method thereof, personalized design and manufacturing are performed according to CT scanning charts of the bone defect parts of patients; the cellular structure, pore diameter, porosity and the like of the material can be accurately controlled, and the matching between the degradation speed and the regeneration speed of different bone defect parts is realized.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to a chitosan / HA-based personalized cranial, maxillofacial and vertebral repair material and a preparation method thereof. Background technique [0002] Clinically, there are more and more bone defects caused by tumor, infection, trauma and congenital malformation, which not only affect the external appearance and function of the patient, but also bring inconvenience to the life of the patient, and even threaten their life. For the treatment of bone defects in load-bearing parts such as the cranium, maxillofacial area, spine, and limb bones, the material needs to bear the force of the body in all directions after implantation, so there are high requirements for the mechanical properties of the material. [0003] At present, there are two types of bone defect repair materials commonly used in clinical practice: non-absorbable materials and absorbable materials. Non-absorbable m...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/48A61L27/56A61L27/58
CPCA61L27/46A61L27/48A61L27/56A61L27/58A61L2430/02C08L5/08
Inventor 张其清张瑗邢永振袁平王临钊陈灵艳段治伟林越威
Owner 福建吉特瑞生物科技有限公司
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