A multi-nozzle collaborative cell/soft tissue 3D printing device

A 3D printing and soft tissue technology, applied in 3D object support structures, manufacturing tools, additive manufacturing, etc.

Active Publication Date: 2021-06-15
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the vascularization of large tissues in vitro, and the anastomotic growth of blood vessels at the host injury site after implantation and the survival of cell / scaffold complexes are also urgently studied.

Method used

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  • A multi-nozzle collaborative cell/soft tissue 3D printing device
  • A multi-nozzle collaborative cell/soft tissue 3D printing device
  • A multi-nozzle collaborative cell/soft tissue 3D printing device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] The present invention will be described in detail below through specific embodiments and accompanying drawings.

[0021] The present invention is a multi-nozzle collaborative cell / soft tissue 3D printing device, such as figure 1 As shown, it includes the test bench 1, the upper surface of the test bench 1 is provided with an operation table 2 and a sterile box 11, and the side opening end of the sterile box 11 is equipped with a box cover, and the box cover is provided with a handle. There are a plurality of syringe pumps 3, and each syringe pump 3 is connected with a storage tank 4, and the outlet of each storage tank 4 is respectively connected with a printing nozzle 6 through a material guide tube 5, and the printing nozzle 6 includes a substrate printing nozzle, a vascular network printing nozzle, skin tissue printing nozzle and neural network printing nozzle; the center of the top of the sterile box 11 is also provided with an ultraviolet lamp;

[0022] Such as ...

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PUM

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Abstract

The invention discloses a multi-nozzle cooperative cell/soft tissue 3D printing device, which includes an experiment platform, an operation platform and a sterile box are arranged on the upper surface of the experiment platform, and a plurality of injection pumps are arranged on the operation platform, and each injection pump is connected to There is a material storage barrel, and the outlet of each material storage barrel is respectively connected with a printing nozzle through a material guide tube, and a three-dimensional movement mechanism is arranged in the aseptic box. According to the tissues to be printed, realize coordinated movement and print the plane structure. At the same time, after each layer is printed, the printing substrate located under the print head will descend along the Z-axis direction to adjust the height under the action of the lead screw; through the print head Co-printing and multi-layer accumulation finally realize the integration and self-assembly of bulk multi-layer tissues.

Description

technical field [0001] The invention belongs to the technical field of 3D printing equipment, and in particular relates to a multi-nozzle coordinated cell / soft tissue 3D printing device. Background technique [0002] Soft tissue damage and loss of function caused by congenital defects, injuries, metabolic diseases and other reasons are common clinical problems and an important cause of human disease and death. For soft tissue defects, the main treatment method at present is to take the healthy tissue of the donor for surgical transplantation, but due to the limited source of available tissue, the damage to the donor site is relatively large, and the allogeneic transplantation is prone to immune rejection, making it Application is limited. With the development of bio-3D printing technology, especially in the development and application of soft tissue engineering, it has brought new hope to solve clinical problems such as soft tissue defect and loss of function. [0003] Bio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B29C64/112B29C64/20B33Y10/00B33Y30/00
CPCB33Y10/00B33Y30/00B29C64/112B29C64/20
Inventor 董贵荣李宏林张伟明杨晨阳胡逸晨
Owner XIAN UNIV OF TECH
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