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A kind of au@se@pt-ce6 nanocomposite probe and its preparation method

A nano-composite and probe technology, applied in drug combination, pharmaceutical formulation, photodynamic therapy, etc., can solve the problems of inability to achieve oxygen production, discount of therapeutic effect, lack of photosensitizer, etc., to enhance the effect of photodynamic therapy, disperse Good, high light-to-heat conversion efficiency

Active Publication Date: 2021-10-29
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Au@Se is mainly used as a photothermal reagent, which cannot produce oxygen in situ at the tumor site, lacks photosensitizers, and has poor stability during heating, which greatly reduces the therapeutic effect.

Method used

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  • A kind of au@se@pt-ce6 nanocomposite probe and its preparation method
  • A kind of au@se@pt-ce6 nanocomposite probe and its preparation method
  • A kind of au@se@pt-ce6 nanocomposite probe and its preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) 0.5 ml of chloroetic acid (concentration of 24.28 mm) was mixed with 50 ml of deionized water, and the mixture was boiled, then 1 ml of sodium citrate solution (concentration was 34 mm) was allowed to be 15 min, and then cooled to room temperature. The golden nanoparticles were centrifuged with 10,000 rpm and 10 minutes, and the gold nanoparticles were centrifuged and dispersed into 5.5 ml of deionized water. The gold nanoparticles were mixed with a 1.6 mL surfactant PAA solution (concentration 10 mg / ml) at 30 ° C.

[0037] (2) 0.1 ml of selenium dioxide (concentration of 100 mM), 0.15 ml of ascorbic acid (concentration of 200 mm) was added to step (1), and the temperature was 30 ° C, and the reaction was maintained for 10 minutes to obtain a Au @ SE nanoparticle solution.

[0038] (3) After the Au @ SE nanoparticle solution obtained by step (2) is rapidly warmed to 60 ° C, the 0.3 ml of chloroplatinic acid solution (19.3 mm) is slowly added dropwise, and the reaction...

Embodiment 2

[0042] Other all the same embodiments, and different, the surfactant in step 1 is PSS.

Embodiment 3

[0044] Others are all in the same embodiment, and the surface active agent in step 1 is PVP.

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Abstract

The present invention proposes a method for preparing Au@Se@Pt-Ce6 nanocomposite probes, which includes the following steps: (1) preparing gold nanoparticles and mixing the gold nanoparticle solution with the surfactant solution at 20-40°C After uniformity, add selenium source and ascorbic acid to react to obtain Au@Se nanoparticle solution; (2) subsequently, add Pt ion solution to react to obtain Au@Se@Pt nanoparticle solution; (3) perform Modify Ce6 to get Au@Se@Pt‑Ce6. The Au@SePt‑PAH‑Ce6 nanocomposite probe synthesized by this method has good photothermal conversion performance, photodynamic therapy effect, photoacoustic imaging and thermal imaging capabilities, and can be applied to photothermal therapy and photodynamic therapy of tumor cells. therapy and imaging. It has a good application prospect in the multimodal imaging diagnosis and treatment of tumors.

Description

Technical field [0001] The present invention relates to a nanocomposite probe, specifically a Au @ SE @ PT-CE6 nanocomposite probe, belonging to the technical field of functional materials. Background technique [0002] Compared with traditional surgery, chemotherapy, and radiotherapy, phototherapy, especially near infrared light, due to its unique characteristics, including superior tissue penetration capacity, has become a new treatment of cancer treatment. Photodynamic Therapy (PDT) and Photopherapy (PTT) are two main forms of phototherapy, and the photosensitizer / radioactive sensitizer is required to convert light energy into single-line oxygen and thermal energy, so that tumor tissue is destroyed to kill cancer cells. . However, tumor surrounding microenvironment is not conducive to photosensitizers, as photosensitizers require oxygen molecules to kill tumor cells. In addition, photothermal therapy is not uniform around the tumor in the tumor, which cannot make tumors comp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61K41/00A61K49/22A61P35/00A61K33/243
CPCA61K41/0052A61K41/0057A61K49/0002A61K49/225A61P35/00A61K33/243A61K2300/00
Inventor 沈清明苏金中戴叶能赵红海范曲立
Owner NANJING UNIV OF POSTS & TELECOMM
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