Fructose injection of antibiotic drug
A technology for antibiotics and injections, applied in the field of medicine, can solve problems such as reducing the scope of use, and achieve the effects of fast onset, expansion of the scope of use, and ease of use
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Embodiment 1
[0023] Embodiment 1. lomefloxacin hydrochloride fructose injection
[0024] Take an appropriate amount of fructose and add it to an appropriate amount of water for injection to dissolve completely, then add an appropriate amount of activated carbon for needles, stir well, adjust the pH value to 4-4.5 with hydrochloric acid solution, keep it warm at 90°C for 30 minutes, filter while hot to remove the activated carbon; Add an appropriate amount of lomefloxacin hydrochloride to the above fructose filtrate, add water for injection to the full amount, stir evenly, seal the jar with fine filter, sterilize by autoclaving at 115°C for 30 minutes, test and inspect, and pack.
[0025] In the above preparation process, activated carbon is used to adsorb pyrogens and decolorize, and activated carbon is not a component of the injection; in addition, injections with different concentrations can be prepared by controlling the dosage of lomefloxacin hydrochloride and fructose, for example, eac...
Embodiment 2
[0027] Embodiment 2. Ornidazole fructose injection
[0028] Weigh 5 grams of ornidazole and add about 900 ml of water for injection to dissolve, add 50 grams of fructose, stir until completely dissolved, adjust the pH value to about 4.5 with dilute hydrochloric acid, add 0.05% activated carbon for needles, and keep warm for 15 minutes at about 50 ° C. Decarbonize and filter while it is hot, add water for injection to 1000ml, measure the content and pH value of the solution, then fine filter with a 0.45 micron microporous membrane, fill and seal in a 100ml infusion bottle with nitrogen, and sterilize by hot pressing at 115°C 30 minutes, each bottle contains 0.5g ornidazole, 5.0g
[0029] The ornidazole fructose injection consists of ornidazole, fructose, hydrochloric acid, nitrogen and water, wherein the hydrochloric acid and nitrogen are additives, which are respectively pH regulator and protective gas.
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