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A kind of preparation method of anti-house dust mite allergen der p1, Der f1 spray

A spray and allergen technology, applied in the field of indoor dust mite allergen modification, can solve the problems of slow effect, difficulty in thoroughly cleaning the source of mites, easy repetition, etc., achieve low cost, good anti-allergic effect, and broad application market Effect

Active Publication Date: 2021-02-05
NINGBO RHYSUAIR BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dust mites often grow in furnishings such as carpets, sofas, mattresses, and bedding, but simply changing the interior furnishings cannot effectively reduce the level of indoor dust mite allergens
Drying is the most common way to remove mites, but the effect is slow. The source of mites hidden in bedding, carpets, pillow cores, mattresses, etc. is difficult to clean thoroughly, and it is easy to repeat
The measures that have been reported now include freezing method (using refrigerator or liquid nitrogen to freeze blankets, toys, pillowcases, etc.), dry heat method (electric blanket or other heating methods), steam mite killing method, using lindane, benzyl toluene, etc. Chemical removal of mites such as esters, as well as physical methods such as "ultraviolet radiation" and "strong beating", these methods of removing mites cannot achieve the expected results, or there are major deficiencies in home promotion

Method used

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  • A kind of preparation method of anti-house dust mite allergen der p1, Der f1 spray
  • A kind of preparation method of anti-house dust mite allergen der p1, Der f1 spray
  • A kind of preparation method of anti-house dust mite allergen der p1, Der f1 spray

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]Bamboo sticks about 6 cm in length and 2 cm in width and 10 g of camphor leaves were washed three times with deionized water, then placed in an oven at 120 ° C for 5 hours, dried, and the above materials were pulverized into powders with a pulverizer for subsequent use. The above-mentioned bamboo chip powder is put into NaOH cooking liquid and boiled, wherein, the NaOH concentration is 5g / L, and the cooking aid is 3g / L NaOH 2 SiO 3 , the bath ratio is 1:25, the reaction temperature is 100°C, and the reaction time is 110 minutes. After the alkali boiling is completed, the bamboo fiber extract is obtained by filtration and separation, which is set aside. Weigh 6g of crushed camphor leaves, put them into a three-necked flask, select anhydrous ethanol as an organic solvent, control the ratio of solid to liquid at 10:1, extract at a temperature of 50°C, and take a reaction time of 75min, select the organic reagent petroleum ether to distillate Extract 3 times to obtain camph...

Embodiment 2

[0041] Bamboo sticks about 6 cm in length and 2 cm in width and 10 g of camphor leaves were washed three times with deionized water, then placed in an oven at 120 ° C for 5 hours, dried, and the above materials were pulverized into powders with a pulverizer for subsequent use. The above-mentioned bamboo chip powder is put into NaOH cooking liquid and boiled, wherein, the NaOH concentration is 5g / L, and the cooking aid is 3g / L NaOH 2 SiO 3 , the bath ratio is 1:25, the reaction temperature is 100°C, and the reaction time is 110 minutes. After the alkali boiling is completed, the bamboo fiber extract is obtained by filtration and separation, which is set aside. Weigh 6g of crushed camphor leaves, put them into a three-necked flask, select anhydrous ethanol as an organic solvent, control the ratio of solid to liquid at 10:1, extract at a temperature of 50°C, and take a reaction time of 75min, select the organic reagent petroleum ether to distillate Extract 3 times to obtain camp...

Embodiment 3

[0044] Bamboo sticks about 6 cm in length and 2 cm in width and 10 g of camphor leaves were washed three times with deionized water, then placed in an oven at 120 ° C for 5 hours, dried, and the above materials were pulverized into powders with a pulverizer for subsequent use. The above-mentioned bamboo chip powder is put into NaOH cooking liquid and boiled, wherein, the NaOH concentration is 5g / L, and the cooking aid is 3g / L NaOH 2 SiO 3 , the bath ratio is 1:25, the reaction temperature is 100°C, and the reaction time is 110 minutes. After the alkali boiling is completed, the bamboo fiber extract is obtained by filtration and separation, which is set aside. Weigh 6g of crushed camphor leaves, put them into a three-necked flask, select anhydrous ethanol as an organic solvent, control the ratio of solid to liquid at 10:1, extract at a temperature of 50°C, and take a reaction time of 75min, select the organic reagent petroleum ether to distillate Extract 3 times to obtain camp...

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Abstract

The invention discloses a preparation method of Der p1 and Der f1 sprays against house dust mite allergens. The preparation process comprises the following steps: pretreating bamboo chips and camphor leaves, and pulverizing them into powders respectively with a pulverizer; the bamboo chip powder Carry out chemical degumming treatment, separate and obtain bamboo fiber extract, weigh a certain amount of camphor leaf powder, place it in a distillation bottle, disperse evenly, and distill under reduced pressure; then carry out chlorophyll removal treatment; conduct preliminary separation by chromatography , to obtain crude product; use liquid chromatography to refine to obtain high-purity pure natural plant extract; recrystallize and purify bamboo fiber to obtain white powder; combine the above two active ingredients with a certain mass percentage of buffer, surface active Agent, quick-drying agent and solvent are uniformly mixed to prepare the dust mite anti-allergy spray. The preparation process of the present invention is simple and easy to operate, low in cost, good in anti-allergic effect of house dust mite and has no side effect on human body, so it has broad application market in the field of modification of house dust mite allergy protein.

Description

technical field [0001] The invention belongs to the field of house dust mite allergen modification, and in particular relates to a preparation method of an anti-house dust mite allergen Der p1 and Der f1 spray. Background technique [0002] House Dust Mites is an important allergen that widely exists in human living and working environments. The body size of mites is only about 0.5-0.1 mm, and it is difficult for people to see mite bodies, mite eggs, excrement and death with the naked eye. Mites can become allergens, causing allergic asthma, allergic rhinitis, dermatitis and other allergic diseases. At present, there are more than 8 million children with allergic asthma in my country, among which asthma cases account for 80%. Studies have found that there are more than 20 kinds of allergenic proteins in dust mites, and household / house dust mite (Dermatophagoides pteronyssinus, Der p) and dust mite (Dermatophagoides farinae, Der f) are the two most common dominant and deadly...

Claims

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Application Information

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IPC IPC(8): A01N65/26A01N65/44A01N25/06A01P7/02
Inventor 周剑
Owner NINGBO RHYSUAIR BIOTECHNOLOGY CO LTD
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