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Ginsenoside-warfarin self-assembly nano gel and application thereof

A technology of ginsenoside and nanogel, which is applied in the direction of drug combinations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems that have not been reported in the application, and achieve high drug loading, high stability, and small particle size. diameter effect

Inactive Publication Date: 2019-06-14
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Warfarin can improve the survival of cancer patients and has potential antitumor activity, but the application of the combination of the two in antitumor metastasis has not been reported

Method used

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  • Ginsenoside-warfarin self-assembly nano gel and application thereof
  • Ginsenoside-warfarin self-assembly nano gel and application thereof
  • Ginsenoside-warfarin self-assembly nano gel and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 5.0 g of total ginseng saponins and add acetic acid aqueous solution with a pH of 1.8 to react at 90°C for 4 h. After the reactant is left at room temperature for 2 h, filter it with a 0.45 μm filter membrane to remove impurities; filter the filtrate with 10% sodium carbonate The pH of the solution reached 7.5, and the precipitate was left to stand, and the precipitate was collected by vacuum filtration; the precipitate was heated to 60°C in absolute ethanol to dissolve, then placed at 4°C for 2 h, filtered with a filter membrane, and the filtrate was collected and concentrated under reduced pressure. Put the concentrate into absolute ethanol to dissolve, then place it at 4°C for 2 h, filter it with a 2 μm filter membrane, concentrate and dry the filtrate under reduced pressure to obtain ginsenoside nanogel; take warfarin and ginsenoside gel powder, add secondary water, make the final concentration of ginsenoside in the solution be 1-10 mg / mL, and the concentration...

Embodiment 2

[0030] Example 2 Characterization of Ginsenoside-Warfarin Nanogel

[0031] The particle size (size, nm) and potential (zeta potential, mv) of the nanogel were measured by dynamic light scattering (DLS), and the results were as follows figure 1 shown.

[0032] Depend on figure 1 It can be seen that the nanogel prepared by the present invention has a small particle size and a negative potential.

Embodiment 3

[0033] Example 3 Characterization of Ginsenoside-Warfarin Nanogel Structure

[0034] The three-dimensional structure of the nanogel was determined by atomic force microscopy (AFM), and the results were as follows: figure 2 shown.

[0035] Depend on figure 2 It can be seen that the ginseng soap-warfarin prepared by the present invention has a linear structure.

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Abstract

The invention discloses ginsenoside-warfarin self-assembly nano gel and application thereof. The method specifically comprises the step that warfarin and ginsenoside gel nano particles are mixed in water and subjected to ultrasonic treatment for 15 min to be self-assembled to form a ginsenoside-warfarin nano gel conveying system, wherein the average particle size of the nano gel is 15-60 nm. According to the preparation method, the ginsenoside and the warfarin are creatively combined to prepare the nano gel, and the nano gel prepared through the method can be used for preparing cardiovasculardrugs and has a very high inhibition effect on proliferation, migration and adhesion of cancer cells so that the nano gel can be used for preparing anti-tumor-metastasis drugs.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and specifically relates to a ginsenoside-warfarin self-assembled nanogel and an application thereof. Background technique [0002] Cancer is a very destructive disease that threatens the health of all human beings. In my country, cancer has become the primary cause of death among residents, and tumor metastasis is the main cause of death in cancer patients. Clinically, more than 90% of cancer patients die. Because of tumor metastasis rather than the primary tumor, although the primary tumor can be controlled to a certain extent after surgery, it faces the risk of tumor recurrence and metastasis. Once the tumor cells metastasize, it is difficult to be cured by surgery. Tumor metastasis is a process in which the primary site of the tumor directly expands to the surrounding area, or metastatic tumor cells settle in distant tissues through blood or lymphatic channels to form new t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/37A61K31/704A61K36/258A61P9/00A61P35/04
Inventor 邵敬伟何小宇邓昌勇郭燕
Owner FUZHOU UNIV
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