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A kind of degradable polyurethane biological material and its preparation method and application

A biomaterial and polyurethane technology, applied in the field of degradable polyurethane biomaterials and their preparation, can solve the problems of poor biomedical properties, physical and chemical properties of medical device products, and reduce the risk of inflammation, small pH changes, and effectiveness. Good results

Active Publication Date: 2021-02-05
苏州瑞济诺医疗科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] What the present invention intends to solve is the technical problem that the biomedical properties, physical and chemical properties of alternating block polyurethane biomaterials and the effectiveness of corresponding medical device products are relatively poor in the prior art

Method used

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  • A kind of degradable polyurethane biological material and its preparation method and application
  • A kind of degradable polyurethane biological material and its preparation method and application
  • A kind of degradable polyurethane biological material and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Alternating block polyurethanes are prepared by the method of the present invention.

[0046] (1) Aliphatic polyether diol, the raw material of the second polymer, model is: polyether N-210 (molecular weight is 1000, purchased from Nanjing Xinyuan Chemical Co., Ltd.), ethylene glycol, propylene glycol, 1,4 -Butanediol is added in chloroform according to the mass ratio of 1:1:1:1, stirred and dissolved completely to obtain solution I; at this time, the mass ratio of aliphatic polyether diol to aliphatic diol is 1:3, The mass ratio of ethylene glycol, propylene glycol, and 1,4-butanediol in the aliphatic dihydric alcohol is 1:1:1;

[0047] (2) In the three-necked flask, the raw material diisocyanate of the first polymer is obtained by end-capping reaction to obtain the aliphatic polyester diol terminated by diisocyanate; wherein the diisocyanate is hexamethylene diisocyanate, and the aliphatic polyester diol The model is Oxyester T1136, Evonik (for linear polyester diol,...

Embodiment 2

[0051] By using the method of the present invention, the alternating block polyurethane prepared by using the mixture in the second polymer as a proportion outside the preferred range of the present invention.

[0052] (1) Aliphatic polyether diol, the raw material of the second polymer, is: polyether N-210, ethylene glycol, propylene glycol, and 1,4-butanediol in a mass ratio of 1:10:10: 10 was added to chloroform, stirred and dissolved completely to obtain solution I; at this time, the mass ratio of aliphatic polyether diol to aliphatic diol was 1:30, and in aliphatic diol, ethylene glycol, propylene glycol, 1, The mass ratio of 4-butanediol is 1:1:1;

[0053] (2) In a three-necked flask, utilize end-capping reaction (reaction conditions are the same as Example 1) to obtain the raw material diisocyanate end-blocked aliphatic polyester diol of the first polymer; wherein diisocyanate is hexamethylene diisocyanate , the aliphatic polyester diol model is Oxyester T1136, Evonik;...

Embodiment 3

[0056] By using the method of the present invention, the alternating block polyurethane prepared by using the mixture in the second polymer as a proportion outside the preferred range of the present invention.

[0057] (1) Aliphatic polyether diol, the raw material of the second polymer, is: polyether N-210, ethylene glycol, propylene glycol, and 1,4-butanediol in a mass ratio of 1:1:15: 15 was added into chloroform, stirred and dissolved completely to obtain solution I; at this time, the mass ratio of aliphatic polyether diol to aliphatic diol was 1:31, and in aliphatic diol, ethylene glycol, propylene glycol, 1, The mass ratio of 4-butanediol is 1:15:15;

[0058] (2) In a three-necked flask, utilize end-capping reaction (reaction conditions are the same as Example 1) to obtain the raw material diisocyanate end-blocked aliphatic polyester diol of the first polymer; wherein diisocyanate is hexamethylene diisocyanate , the aliphatic polyester diol model is Oxyester T1136, Evon...

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Abstract

The invention belongs to the field of biomedical high-molecular materials, and discloses an alternative block polyurethane biomaterial as well as a preparation method and application thereof. The polyurethane biomaterial is formed by alternative arrangement of a first block formed by a first polymer and a second block formed by a second polymer; and a diisocyanate-terminated aliphatic polyester diol is used as a first polymer raw material, a mixture of an aliphatic polyether diol and an aliphatic diol is used as a second polymer raw material, a polymerization reaction is performed, and therefore the polyurethane biomaterial polyurethane biomaterial is prepared. The polyurethane biomaterial provided by the invention is applied to a biodegradable implantable and non-implantable medical device, during degradation of the material, the pH changes little, and the biomedical properties and physical and chemical properties of the biomedical material and effectiveness of corresponding medical device products are better.

Description

technical field [0001] The invention relates to the field of biomedical polymer materials, in particular to a biodegradable polyurethane biomaterial and its preparation method and application. Background technique [0002] Biodegradable polymer materials have good mechanical properties and biocompatibility, so they have a wide range of applications in the biomedical field. However, the degradation process of traditional biomaterials such as polylactic acid (PLLA), polylactic-co-glycolic acid (PLGA), polycaprolactone (PCL) and other implanted medical devices will produce acidic product carboxyl groups, leading to inflammation in the body , affect tissue regeneration and rehabilitation, and also have an impact on the performance of medical devices. [0003] Biodegradable polyurethane materials will produce acidic carboxyl groups and basic amine groups during the degradation process, which will not significantly reduce the pH in the body, reduce the risk of inflammation in the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/66C08G18/48C08G18/42C08G18/32A61L27/58A61L27/18
Inventor 许开天
Owner 苏州瑞济诺医疗科技有限责任公司
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