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Antihypertensive capsule and preparation method

A capsule and temperature control technology, applied in capsule delivery, pharmaceutical formula, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2019-05-21
福建省南平市人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still many problems. For example, the research on the antihypertensive mechanism of traditional Chinese medicine needs to be deepened. A series of systematic, multi-level, and multi-effect studies on single Chinese medicine and compound Chinese medicine should be carried out from multiple perspectives and multi-layered. Using modern advanced science and technology, Study the antihypertensive effect and mechanism of traditional Chinese medicine from the level of signs, organs, cells and even molecules, and screen out the compound preparation of Chinese and Western medicine for Jiangya Capsules; improve the shortcomings of traditional Chinese medicine in the treatment of essential hypertension, and make Western medicine play its due role The combination of traditional Chinese medicine and western medicine can better treat high blood pressure. The combined treatment of Jiangya Capsules with Chinese and western medicine can take advantage of the rapid and reliable antihypertensive effect of western medicine. relationship, give full play to the advantages of traditional Chinese medicine in treating diseases fundamentally, reduce the pathological factors that cause hypertension, improve the symptoms of patients, and improve their quality of life

Method used

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preparation example Construction

[0037] Such as figure 1 As shown, the preparation method of the antihypertensive capsule provided by the embodiment of the present invention comprises:

[0038] S101: Select high-quality Uncaria, Radix Paeoniae Alba, Nifedipine, Atenolol and Hydrochlorothiazide;

[0039] S102: Sorting Uncaria and Radix Paeoniae Alba and identifying them respectively, and identifying Nifedipine, Atenolol and Hydrochlorothiazide respectively;

[0040] S103: take the two traditional Chinese medicines of Uncaria and Radix Paeoniae Alba, grind them into fine powder 1 for later use; take the three herbs of nifedipine, atenolol and hydrochlorothiazide, and grind them into fine powder 2 for later use;

[0041] S104: Mix the fine powder 1 in step S102 evenly, put it in a constant temperature drying oven, control the thickness of the fine powder in the square plate to 2cm, control the sterilization temperature at 105°C for 12 hours to sterilize, close the constant temperature drying oven, and wait unti...

Embodiment 1

[0057] Example 1. Identification

[0058] (1) Take 2.5g of the content of this product, add 15ml of water-saturated n-butanol, ultrasonically treat for 15 minutes, filter, evaporate the filtrate to dryness, add 2ml of ethanol to the residue to dissolve, and use it as the test solution. Take another appropriate amount of paeoniflorin reference substance, add ethanol to make a solution containing 1mg per 1ml, as the reference substance solution. According to the test of thin-layer chromatography (Appendix VIB, Chinese Pharmacopoeia, 2015 Edition), draw 10 μl of each of the above two solutions, spot them on the same silica gel G thin-layer plate, and dichloromethane-ethyl acetate-methanol-formic acid (40 : 5: 10: 0.2) as the developing agent, develop, take out, dry in the air, spray with 5% vanillin sulfuric acid solution, and heat until the spots are clearly colored.

[0059] In the chromatogram of the test product, there are spots of the same color at the position correspondin...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and discloses an antihypertensive capsule and a preparation method. The capsule comprises 250 g of uncaria, 200 g of radixpaeoniae alba, 10.0 g of nifedipine, 12.5 g of atenolol and 6.25 g of hydrochlorothiazide. Good-quality uncaria, radix paeoniae alba, nifedipine, atenolol and hydrochlorothiazide are selected; uncaria and radix paeoniae alba are obtained and smashed into fine powder; nifedipine, atenolol and hydrochlorothiazide are ground into fine powder; sterilization is carried out, the uncaria fine powder andthe radix paeoniae alba fine powder are put into a constant-temperature drying box, the thickness of the fine powder in a square disc is controlled to be 2 cm, the sterilization temperature is controlled to be 105 DEG C, the constant-temperature drying box is shut down after 12 hours, and after the temperature is reduced to normal temperature, the fine powder is evenly mixed with the fine powder2 to obtain mixed fine powder; the uncaria fine powder, the radix paeoniae alba fine powder and the nifedipine, atenolol and hydrochlorothiazide fine powder are evenly mixed to obtain mixed fine powder for use; the mixed fine powder is loaded into empty capsules to prepare 100 capsules, the capsules are bottled, and antihypertensive capsules are obtained.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a hypotensive capsule and a preparation method thereof. Background technique [0002] At present, the existing technologies commonly used in the industry are as follows: [0003] The kallikrein kinin system is a complex endogenous multi-enzyme system, mainly composed of kininogen, kallikrein and kinin, widely present in blood and many organs and tissues, and participates in It regulates various physiological functions such as blood pressure, body fluid and electrolyte balance, and diseases such as inflammation, pain and cell proliferation; it is closely related to the occurrence and development of hypertension and its target organ damage. Compound traditional Chinese medicine has blood pressure regulation and target organ protection, and part of its mechanism of action is related to the balance regulation of kallikrein-kinin system. [0004] KK...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61K9/48A61P9/12A61K31/4422A61K31/165A61K31/549
Inventor 余天泰纪世健徐心宇许智勤李小英施美利
Owner 福建省南平市人民医院
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